Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis

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Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

(2021) Kengo Watanabe et al.   Nature Communications

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

(2021) Georg Krainer et al.   Nature Communications

PA28γ: New Insights on an Ancient Proteasome Activator

(2021) Paolo Cascio   Biomolecules

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

(2021) Jocelyn C. Newton et al.   BIOPHYSICAL JOURNAL

N-terminal Domain of TDP43 Enhances Liquid-Liquid Phase Separation of Globular Proteins

(2021) G. Campbell Carter et al.   JOURNAL OF MOLECULAR BIOLOGY

Stress- and ubiquitylation-dependent phase separation of the proteasome

(2020) Sayaka Yasuda et al.   NATURE

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

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Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

(2020) T. Ukmar-Godec et al.   Science Advances

Initiation of stress granule assembly by rapid clustering of IGF2BP proteins upon osmotic shock

(2020) Wei-jie Zeng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The proline-rich domain promotes Tau liquid–liquid phase separation in cells

(2020) Xuemei Zhang et al.   JOURNAL OF CELL BIOLOGY

Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change

(2020) Ameya P. Jalihal et al.   MOLECULAR CELL

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

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Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2019) Dan Bracha et al.   CELL

Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch

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ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

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Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments

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Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration

(2018) Kwadwo A. Opoku-Nsiah et al.   Translational Research

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles

(2017) Ming-Tzo Wei et al.   Nature Chemistry

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

BAG2 expression dictates a functional intracellular switch between the p38-dependent effects of nicotine on tau phosphorylation levels via the α7 nicotinic receptor

(2016) Adriele Silva Alves de Oliveira et al.   EXPERIMENTAL NEUROLOGY

Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington’s disease YAC128 mice

(2016) J. Jeon et al.   NEUROSCIENCE

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

BAG2 Is Repressed by NF-κB Signaling, and Its Overexpression Is Sufficient to Shift Aβ1-42 from Neurotrophic to Neurotoxic in Undifferentiated SH-SY5Y Neuroblastoma

(2015) Fernando E. Santiago et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domain

(2014) Jee-Young Mock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous Expression of Multiple Proteins Under a Single Promoter in Caenorhabditis elegans via a Versatile 2A-Based Toolkit

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Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexesin Vitro

(2013) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Global Fitting of Large Fluorescence Lifetime Imaging Microscopy Datasets

(2013) Sean C. Warren et al.   PLoS One

Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Ubiquitin ligases and beyond

(2012) Ivan Dikic et al.   BMC BIOLOGY

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Improving FRET dynamic range with bright green and red fluorescent proteins

(2012) Amy J Lam et al.   NATURE METHODS

Macromolecular Crowding Regulates Assembly of mRNA Stress Granules after Osmotic Stress

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Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions

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Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

(2009) D. C. Carrettiero et al.   JOURNAL OF NEUROSCIENCE

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Comparison of optical saturation effects in conventional and dual-focus fluorescence correlation spectroscopy

(2008) Anastasia Loman et al.   CHEMICAL PHYSICS LETTERS

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

(2008) Zhen Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Precise Measurement of Diffusion Coefficients using Scanning Fluorescence Correlation Spectroscopy

(2007) Zdeněk Petrášek et al.   BIOPHYSICAL JOURNAL