PA28γ: New Insights on an Ancient Proteasome Activator

The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα–SOD2 pathway

(2020) Yifan Xie et al.   CELL DEATH AND DIFFERENTIATION

Proteasome activator PA28γ-dependent degradation of coronavirus disease (COVID-19) nucleocapsid protein

(2020) Haiyang Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatitis B virus X protein stimulates cell growth by downregulating p16 levels via PA28γ-mediated proteasomal degradation

(2020) Sungkyung Cha et al.   JOURNAL OF GENERAL VIROLOGY

Role of oncogenic REGγ in cancer

(2020) Maolei Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

(2020) Jean Lesne et al.   Nature Communications

Molecular and cellular dynamics of the 26S proteasome

(2020) Eri Sakata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mechanisms of substrate recognition by the 26S proteasome

(2020) Caroline Davis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

(2019) Jiao Fan et al.   Nature Communications

Expression of REGγ in atherosclerotic plaques and promotes endothelial cells apoptosis via the cyclophilin A pathway indicates functional implications in atherogenesis

(2019) Yifan Xie et al.   CELL CYCLE

The proteasome activator REGγ counteracts immunoproteasome expression and autoimmunity

(2019) Liangfang Yao et al.   JOURNAL OF AUTOIMMUNITY

REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells

(2019) Lei Zhou et al.   Cellular & Molecular Immunology

The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling

(2019) Xiao Gao et al.   Stem Cell Reports

The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis

(2019) Stanley C. Xie et al.   Nature Microbiology

Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis

(2019) Lu Tong et al.   CELL DEATH AND DIFFERENTIATION

The Immunoproteasome: An Emerging Target in Cancer and Autoimmune and Neurological Disorders

(2019) Breanna L. Zerfas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteasomes: unfoldase-assisted protein degradation machines

(2019) Parijat Majumder et al.   BIOLOGICAL CHEMISTRY

REGγ potentiates TGF-β/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells

(2019) Muhammad Zeeshan Bhatti et al.   CELLULAR SIGNALLING

Understanding the 26S proteasome molecular machine from a structural and conformational dynamics perspective

(2019) Eric R Greene et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

PA28γ acts as a dual regulator of IL-6 and CCL2 and contributes to tumor angiogenesis in oral squamous cell carcinoma

(2018) Sai Liu et al.   CANCER LETTERS

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ

(2018) Beata Jonik-Nowak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome

(2018) Yanan Zhu et al.   Nature Communications

The immunoproteasome and thymoproteasome: functions, evolution and human disease

(2018) Shigeo Murata et al.   NATURE IMMUNOLOGY

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

(2018) Yuanchen Dong et al.   NATURE

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

PSME3 induces epithelial–mesenchymal transition with inducing the expression of CSC markers and immunosuppression in breast cancer

(2017) Ziying Yi et al.   EXPERIMENTAL CELL RESEARCH

Knockdown of REGγ inhibits the proliferation and migration and promotes the apoptosis of multiple myeloma cells by downregulating NF-κB signal pathway

(2017) Shuang Liu et al.   Hematology

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α 4 β 3 Complex

(2017) Eva M. Huber et al.   STRUCTURE

The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms

(2017) Jill M. Yersak et al.   Frontiers in Molecular Neuroscience

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

(2016) Andrija Finka et al.   Annual Review of Biochemistry

Emerging role of immunoproteasomes in pathophysiology

(2016) Gagandeep Kaur et al.   IMMUNOLOGY AND CELL BIOLOGY

Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes

(2016) Vanessa Welk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington’s disease YAC128 mice

(2016) J. Jeon et al.   NEUROSCIENCE

Structural basis for dynamic regulation of the human 26S proteasome

(2016) Shuobing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome

(2016) Lianhui Sun et al.   Nature Communications

Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

(2016) Lin Huang et al.   Scientific Reports

The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens

(2016) Jinxia Sun et al.   Cell Reports

The Expression and Clinical Significance of PA28 γ in Colorectal Cancer

(2016) Debo Chen et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity

(2015) Anja Moncsek et al.   APOPTOSIS

miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ

(2015) Yuan Shi et al.   CANCER LETTERS

Evolution of Proteasome Regulators in Eukaryotes

(2015) Philippe Fort et al.   Genome Biology and Evolution

Pioneer translation products as an alternative source for MHC-I antigenic peptides

(2015) Sebastien Apcher et al.   MOLECULAR IMMUNOLOGY

REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway

(2015) Lei Li et al.   Nature Communications

Enhanced rate of degradation of basic proteins by 26S immunoproteasomes

(2014) Mary Raule et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of c-Myc protein stability by proteasome activator REGγ

(2014) S Li et al.   CELL DEATH AND DIFFERENTIATION

PA28αβ Reduces Size and Increases Hydrophilicity of 20S Immunoproteasome Peptide Products

(2014) Mary Raule et al.   CHEMISTRY & BIOLOGY

PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis

(2014) Shuang Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Label-Free Quantitative Proteomics Reveals the Dynamics of Proteasome Complexes Composition and Stoichiometry in a Wide Range of Human Cell Lines

(2014) Bertrand Fabre et al.   JOURNAL OF PROTEOME RESEARCH

Dusp3 and Psme3 Are Associated with Murine Susceptibility to Staphylococcus aureus Infection and Human Sepsis

(2014) Qin Yan et al.   PLoS Pathogens

Structural Biology of the Proteasome

(2013) Erik Kish-Trier et al.   Annual Review of Biophysics

Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form

(2013) Masaaki Sugiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The complexity of recognition of ubiquitinated substrates by the 26S proteasome

(2013) Aaron Ciechanover et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy

(2013) Shuxian Dong et al.   Cell Metabolism

Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway

(2013) S. Apcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-scale prediction of proteins with long intrinsically disordered regions

(2013) Zhenling Peng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

REGγ is associated with multiple oncogenic pathways in human cancers

(2012) Jing He et al.   BMC CANCER

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks

(2012) Adva Levy-Barda et al.   CELL CYCLE

Emerging roles of immunoproteasomes beyond MHC class I antigen processing

(2012) Frédéric Ebstein et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Model of the Human 26S Proteasome

(2012) Paula C.A. da Fonseca et al.   MOLECULAR CELL

Proteasome allostery as a population shift between interchanging conformers

(2012) A. M. Ruschak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REGγ/PA28γ proteasome activator interacts with PML and Chk2 and affects PML nuclear bodies number

(2011) Laura Zannini et al.   CELL CYCLE

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase

(2011) Yasuhiro Uchimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteasome Activators

(2011) Beth M. Stadtmueller et al.   MOLECULAR CELL

Mice completely lacking immunoproteasomes show major changes in antigen presentation

(2011) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation

(2011) S. Apcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REGγ proteasome activator is involved in the maintenance of chromosomal stability

(2010) Laura Zannini et al.   CELL CYCLE

REGγ modulates p53 activity by regulating its cellular localization

(2010) Jian Liu et al.   JOURNAL OF CELL SCIENCE

REG gamma: a potential marker in breast cancer and effect on cell cycle and proliferation of breast cancer cell

(2010) Xiaoyi Wang et al.   MEDICAL ONCOLOGY

The nanny model for IDPs

(2009) Peter Tsvetkov et al.   Nature Chemical Biology

The proteasome 11S regulator subunit REGα (PA28α) is a heptamer

(2009) Steven C. Johnston et al.   PROTEIN SCIENCE

A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the α-Ring Channel

(2009) Pawel A. Osmulski et al.   STRUCTURE

Structure and dynamics of the N-terminal half of hepatitis C virus core protein: An intrinsically unstructured protein

(2008) Jean-Baptiste Duvignaud et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

REGγ, a proteasome activator and beyond?

(2008) I. Mao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteasome activator PA28γ regulates p53 by enhancing its MDM2-mediated degradation

(2008) Zhuo Zhang et al.   EMBO JOURNAL

Structure of the Human 26S Proteasome

(2008) Paula C. A. da Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling the in Vitro 20S Proteasome Activity: The Effect of PA28–αβ and of the Sequence and Length of Polypeptides on the Degradation Kinetics

(2008) Michele Mishto et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms: a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28 -Dependent Mechanism

(2008) R. Suzuki et al.   JOURNAL OF VIROLOGY

A Novel Role for PA28γ-Proteasome in Nuclear Speckle Organization and SR Protein Trafficking

(2008) Véronique Baldin et al.   MOLECULAR BIOLOGY OF THE CELL

Human full-length Securin is a natively unfolded protein

(2005) Nuria Sánchez-Puig et al.   PROTEIN SCIENCE