Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Authors
Keywords
-
Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-06-01
DOI
10.1038/s41467-022-29703-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation
- (2021) Daniel K Weber et al. eLife
- Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
- (2021) Niels Grote Beverborg et al. Nature Communications
- Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology
- (2020) Congcong Zhang et al. BIODRUGS
- Lipid nanoparticles for nucleic acid delivery: Current perspectives
- (2020) Eleni Samaridou et al. ADVANCED DRUG DELIVERY REVIEWS
- Rapid Delivery of Nanobodies/VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA
- (2020) Xuechen Zhou et al. Molecular Therapy-Methods & Clinical Development
- Atomistic Structure and Dynamics of the Ca2+-ATPase Bound to Phosphorylated Phospholamban
- (2020) Rodrigo Aguayo-Ortiz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban
- (2020) Julia Menzel et al. Science Signaling
- An Inside Job: Applications of Intracellular Single Domain Antibodies
- (2020) Eline Soetens et al. Biomolecules
- Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
- (2019) Nicola Fenderico et al. Nature Communications
- Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
- (2019) Li-Ming Gan et al. Nature Communications
- Adeno-associated virus vector as a platform for gene therapy delivery
- (2019) Dan Wang et al. NATURE REVIEWS DRUG DISCOVERY
- Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders
- (2019) Anne Messer et al. NEUROBIOLOGY OF DISEASE
- The rapidly evolving state of gene therapy
- (2018) Alisha M. Gruntman et al. FASEB JOURNAL
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine
- (2018) Leif Carlsson et al. Molecular Therapy-Methods & Clinical Development
- Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir
- (2018) William Whyte et al. Nature Biomedical Engineering
- Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
- (2018) Pooja Munnilal Tiwari et al. Nature Communications
- Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
- (2018) Nuphar Veiga et al. Nature Communications
- Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
- (2017) Christiane R Stadler et al. NATURE MEDICINE
- N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
- (2017) Yuri V. Svitkin et al. NUCLEIC ACIDS RESEARCH
- Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions
- (2017) Els Beirnaert et al. Frontiers in Immunology
- Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca2+-ATPase
- (2016) Takatoshi Nakagawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial
- (2016) Barry Greenberg et al. LANCET
- In vitro and ex vivo strategies for intracellular delivery
- (2016) Martin P. Stewart et al. NATURE
- Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?
- (2016) Andrea L.J. Marschall et al. Computational and Structural Biotechnology Journal
- Cardiac BNP gene delivery prolongs survival in aged spontaneously hypertensive rats with overt hypertensive heart disease
- (2016) Jason M. Tonne et al. Aging-US
- A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia
- (2015) Guan-Sheng Liu et al. CARDIOVASCULAR RESEARCH
- Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells
- (2015) Jake Chng et al. mAbs
- Specificin vivoknockdown of protein function by intrabodies
- (2015) Andrea LJ Marschall et al. mAbs
- A general protocol for the generation of Nanobodies for structural biology
- (2014) Els Pardon et al. Nature Protocols
- Nanobodies: Natural Single-Domain Antibodies
- (2013) Serge Muyldermans Annual Review of Biochemistry
- Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
- (2013) Lior Zangi et al. NATURE BIOTECHNOLOGY
- Reprogramming human fibroblasts to pluripotency using modified mRNA
- (2013) Pankaj K Mandal et al. Nature Protocols
- Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban
- (2013) M. Gustavsson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Probing Embryonic Stem Cell Autocrine and Paracrine Signaling Using Microfluidics
- (2012) Laralynne Przybyla et al. Annual Review of Analytical Chemistry
- Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome
- (2012) Evangelia G. Kranias et al. CIRCULATION RESEARCH
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Mutations in the human phospholamban gene in patients with heart failure
- (2011) Alessandra Medeiros et al. AMERICAN HEART JOURNAL
- Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)
- (2011) Mariell Jessup et al. CIRCULATION
- Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats
- (2011) Alessandro Cataliotti et al. CIRCULATION
- Methods in cardiomyocyte isolation, culture, and gene transfer
- (2011) William E. Louch et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Lethal Arg9Cys phospholamban mutation hinders Ca2+-ATPase regulation and phosphorylation by protein kinase A
- (2011) K. N. Ha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
- (2010) Luigi Warren et al. Cell Stem Cell
- Modulation of protein properties in living cells using nanobodies
- (2009) Axel Kirchhofer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
- (2008) Cécile Vincke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection
- (2008) Carmela Zincarelli et al. MOLECULAR THERAPY
- The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases
- (2008) Yoshiaki Kawase et al. Nature clinical practice. Cardiovascular medicine
- Calcium Cycling and Signaling in Cardiac Myocytes
- (2007) Donald M. Bers Annual Review of Physiology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation