Gastrointestinal Involvement in SARS-CoV-2 Infection

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients

(2022) Zhonghan Sun et al.   BMC Medicine

Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine

(2022) Jacob Pitcovski et al.   VACCINE

Current drug targets for gut microbiota biocorrection during the SARS-CoV-2 pandemic: a systematic review.

(2022) Maria V. Sankova et al.   CURRENT DRUG TARGETS

Gut Virome: Role and Distribution in Health and Gastrointestinal Diseases

(2022) Laurie Spencer et al.   Frontiers in Cellular and Infection Microbiology

Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review

(2022) Yeganeh Farsi et al.   Frontiers in Cellular and Infection Microbiology

The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients

(2022) Johanna Reinold et al.   Frontiers in Cellular and Infection Microbiology

A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity

(2022) Bertrand Bellier et al.   Frontiers in Immunology

Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity

(2022) Sabine Hazan et al.   BMJ Open Gastroenterology

Gastrointestinal symptoms are associated with severity of coronavirus disease 2019

(2021) Weibiao Zeng et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms

(2021) Alexandra E. Livanos et al.   GASTROENTEROLOGY

COVID-19 Vaccines (Revisited) and Oral-Mucosal Vector System as a Potential Vaccine Platform

(2021) Muhammad Umer Ashraf et al.   Vaccines

Digestive system symptoms and function in children with COVID-19

(2021) Jiajia Wang et al.   MEDICINE

Immune response induced by oral administration with a Saccharomyces cerevisiae-based SARS-CoV-2 vaccine in mice

(2021) Tong Gao et al.   Microbial Cell Factories

Gastrointestinal manifestations in COVID-19

(2021) Jayani C Kariyawasam et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Advantages of an Oral Vaccine to Control the Covid-19 Pandemic

(2021) Phillip J. Baker   AMERICAN JOURNAL OF MEDICINE

TMPRSS2: An Equally Important Protease as ACE2 in the Pathogenicity of SARS-CoV-2 Infection

(2021) Malvinder S. Parmar   MAYO CLINIC PROCEEDINGS

Abdominal and gastrointestinal manifestations in COVID-19 patients: Is imaging useful?

(2021) Piero Boraschi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

COVID-19-associated diarrhea

(2021) Klara Megyeri et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Gastrointestinal Bleeding in COVID-19 Patients: A Systematic Review with Meta-Analysis

(2021) Giovanni Marasco et al.   Canadian Journal of Gastroenterology and Hepatology

Age-Related Differences in the Expression of Most Relevant Mediators of SARS-CoV-2 Infection in Human Respiratory and Gastrointestinal Tract

(2021) Roberto Berni Canani et al.   Frontiers in Pediatrics

Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19

(2021) Jiezhong Chen et al.   Journal of Clinical Medicine

Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

(2021) Yongjian Wu et al.   npj Biofilms and Microbiomes

Omicron variant (B.1.1.529) of SARS‐CoV‐2, a global urgent public health alert!

(2021) Shou‐Jiang Gao et al.   JOURNAL OF MEDICAL VIROLOGY

Mechanisms of SARS-CoV-2 entry into cells

(2021) Cody B. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Early type 1 diabetes aggravates renal ischemia/reperfusion-induced acute kidney injury

(2021) Mariana Charleaux de Ponte et al.   Scientific Reports

COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission

(2020) Jinyang Gu et al.   GASTROENTEROLOGY

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus

(2020) Weicheng Liang et al.   GUT

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Oral immunization of mice with a multivalent therapeutic subunit vaccine protects against Helicobacter pylori infection

(2020) Meiying Liu et al.   VACCINE

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Coronavirus (COVID-19) Outbreak: What the Department of Radiology Should Know

(2020) Soheil Kooraki et al.   Journal of the American College of Radiology

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

(2020) Dapeng Zhang et al.   Frontiers in Microbiology

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?

(2020) Charleen Yeo et al.   Lancet Gastroenterology & Hepatology

Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission

(2020) Yuan Tian et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China

(2020) Lei Pan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Reply to “Vascular Changes Detected With Thoracic CT in Coronavirus Disease (COVID-19) Might Be Significant Determinants for Accurate Diagnosis and Optimal Patient Management”

(2020) Sana Salehi et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis

(2020) Brandon Michael Henry et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Covid-19 digestive system involvement and clinical outcomes in a large academic hospital in Milan, Italy.

(2020) Alessio Aghemo et al.   Clinical Gastroenterology and Hepatology

Taste Changes (Dysgeusia) in COVID-19: A systematic review and metaanalysis

(2020) Muhammad Aziz et al.   GASTROENTEROLOGY

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

(2020) Tao Zuo et al.   GASTROENTEROLOGY

Initial Gastrointestinal Manifestations in Patients with SARS-CoV-2 in 112 patients from Veracruz (Southeastern Mexico).

(2020) Jose María Remes-Troche; et al.   GASTROENTEROLOGY

Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis

(2020) Ka Shing Cheung et al.   GASTROENTEROLOGY

Gastrointestinal Symptoms and COVID-19: Case-Control Study from the United States

(2020) Yael R. Nobel et al.   GASTROENTEROLOGY

Prevalence and Characteristics of Gastrointestinal Symptoms in Patients with SARS-CoV-2 Infection in the United States: A Multicenter Cohort Study

(2020) Walker D. Redd et al.   GASTROENTEROLOGY

A fatal case of COVID-19 pneumonia occurring in a patient with severe acute ulcerative colitis

(2020) Stefano Mazza et al.   GUT

Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process

(2020) Hao Zhang et al.   GUT

Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection

(2020) Lu Lin et al.   GUT

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

(2020) Xi Jin et al.   GUT

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

(2020) Wenling Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Digestive system involvement of novel coronavirus infection: Prevention and control infection from a gastroenterology perspective

(2020) Lian Yong Li et al.   Journal of Digestive Diseases

Gastrointestinal and Liver Manifestations in Patients with COVID-19

(2020) I-Cheng Lee et al.   Journal of the Chinese Medical Association

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease

(2020) Rachel M. Golonka et al.   PHYSIOLOGICAL GENOMICS

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

(2020) Li Xiao et al.   Viruses-Basel

Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2

(2020) Jiahua He et al.   Viruses-Basel

The liver injury and gastrointestinal symptoms in patients with Coronavirus Disease 19: A systematic review and meta-analysis

(2020) Haizhou Wang et al.   Clinics and Research in Hepatology and Gastroenterology

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis

(2020) Ren Mao et al.   Lancet Gastroenterology & Hepatology

Prolonged presence of SARS-CoV-2 viral RNA in faecal samples

(2020) Yongjian Wu et al.   Lancet Gastroenterology & Hepatology

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

(2020) Rosanna Asselta et al.   Aging-US

The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19

(2020) Qing Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reply to “Segmental Pulmonary Vascular Changes in COVID-19 Pneumonia”

(2020) Sana Salehi et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents

(2020) Lalu Muhammad Irham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Don't Overlook Digestive Symptoms in Patients With 2019 Novel Coronavirus Disease (COVID-19)

(2020) Shihua Luo et al.   Clinical Gastroenterology and Hepatology

Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019

(2020) Zhe Zhu et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Gastrointestinal and hepatic abnormalities in patients with confirmed COVID‐19: A systematic review and meta‐analysis

(2020) Ahmadreza Zarifian et al.   JOURNAL OF MEDICAL VIROLOGY

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

(2020) David H. Brann et al.   Science Advances

Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19

(2020) Gabriella d'Ettorre et al.   Frontiers in Medicine

Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients With Coronavirus Disease 2019

(2020) Sravanthi Parasa et al.   JAMA Network Open

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19

(2020) Mohamad El Moheb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Namrta Choudhry et al.   JOURNAL OF MEDICINAL CHEMISTRY

The roles of nausea and vomiting in COVID-19: did we miss something?

(2020) Tongyue Zhang et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Coronavirus disease 2019 (COVID-19) in patients with systemic autoimmune diseases or vasculitis: radiologic presentation

(2020) Azadeh Eslambolchi et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

The gastrointestinal tract is an alternative route for SARS-CoV-2 infection in a nonhuman primate model

(2020) Li Jiao et al.   GASTROENTEROLOGY

IgA dominates the early neutralizing antibody response to SARS-CoV-2

(2020) Delphine Sterlin et al.   Science Translational Medicine

Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome

(2020) Sonia Villapol   Translational Research

Ischemic gastrointestinal complications of COVID-19: a systematic review on imaging presentation

(2020) Pedram Keshavarz et al.   CLINICAL IMAGING

Community ecology as a framework for human microbiome research

(2019) Jack A. Gilbert et al.   NATURE MEDICINE

A successful history: probiotics and their potential as antimicrobials

(2019) Luigi Santacroce et al.   Expert Review of Anti-Infective Therapy

Oral Immunization of Chickens With Recombinant Lactobacillus plantarum Vaccine Against Early ALV-J Infection

(2019) Shenghua Wang et al.   Frontiers in Immunology

Role of Lactobacillus reuteri in Human Health and Diseases

(2018) Qinghui Mu et al.   Frontiers in Microbiology

Proof of concept in utilizing in-trans surface display system of Lactobacillus plantarum as mucosal tuberculosis vaccine via oral administration in mice

(2018) Anhar Danial Mustafa et al.   BMC BIOTECHNOLOGY

Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study.

(2018) Andrea Ballini et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

(2014) Jian Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin Converting Enzyme-Inhibitor Reduces Colitis Severity in an IL-10 Knockout Model

(2013) Ryo Sueyoshi et al.   DIGESTIVE DISEASES AND SCIENCES

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

(2013) S. K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease

(2008) B. del Rio et al.   Clinical and Vaccine Immunology