Journal
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
Volume 54, Issue 4, Pages 541-546Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.jmii.2020.10.005
Keywords
COVID-19; Nausea; Vomiting; Epidemiology; Mechanism
Categories
Funding
- National Key Research and Development Program of China [2018YFC1312103]
- National Natural Science Founda-tion of China [81972237, 81772623]
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In addition to respiratory symptoms, some COVID-19 patients also experience gastrointestinal symptoms, with nausea/vomiting often being overlooked. The virus can not only attack the lungs but also the gastrointestinal tract. Raising awareness of these symptoms and intervening in a timely manner are crucial in combating COVID-19.
The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an international public health emergency. Although respiratory symptoms predominate the clinical manifestations of COVID-19, gastrointestinal symptoms have been observed in a subset of patients. Notably, some patients have nausea/vomiting as the first clinical manifestation of COVID-19, which is often overlooked by people. It is now clear that not only the lungs, the gastrointestinal tract could also be attacked by SARS-CoV-2. Its host receptor angiotensin-converting enzyme 2 (ACE2), which acts as a gateway to infection, has been found to be highly expressed in the gastrointestinal epithelium and may lead to the development of nausea/vomiting. Raise awareness of these symptoms and take timely intervention would help people combat the pandemic. This review discussed epidemiology, mechanisms, management, and prevention of COVID-1 9 related nausea and vomiting. Copyright (c) 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
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