Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

(2022) Elisabetta Cameroni et al.   NATURE

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

(2022) Dhiraj Mannar et al.   SCIENCE

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

(2022) Baisheng Li et al.   Nature Communications

Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations

(2021) Sugunadevi Sakkiah et al.   Frontiers in Chemistry

Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs

(2021) Paolo Calistri et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

S-variant SARS-CoV-2 lineage B1.1.7 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-qPCR

(2021) Michael Kidd et al.   JOURNAL OF INFECTIOUS DISEASES

Sputnik V COVID-19 vaccine candidate appears safe and effective

(2021) Ian Jones et al.   LANCET

Mutations in SARS-CoV-2; Consequences in structure, function, and pathogenicity of the virus

(2021) Behnaz Bakhshandeh et al.   MICROBIAL PATHOGENESIS

Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein

(2021) Houriiyah Tegally et al.   NATURE

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

(2021) Xuping Xie et al.   NATURE MEDICINE

The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2

(2021) Donald J. Benton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

(2021) Nicholas G. Davies et al.   SCIENCE

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

(2021) Seiya Ozono et al.   Nature Communications

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

(2021) Zharko Daniloski et al.   eLife

Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization

(2021) Pengfei Wang et al.   Cell Host & Microbe

SARS-CoV-2 variants and convalescent plasma: reality, fallacies, and opportunities

(2021) Arturo Casadevall et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+

(2021) Alex L. Lai et al.   JOURNAL OF MOLECULAR BIOLOGY

Inactivated COVID-19 vaccine BBV152/COVAXIN effectively neutralizes recently emerged B.1.1.7 variant of SARS-CoV-2

(2021) Gajanan N Sapkal et al.   JOURNAL OF TRAVEL MEDICINE

SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity

(2021) Muthukumar Ramanathan et al.   LANCET INFECTIOUS DISEASES

Structural impact on SARS-CoV-2 spike protein by D614G substitution

(2021) Jun Zhang et al.   SCIENCE

Association between Social Integration and Face Mask Use Behavior during the SARS-CoV-2 Pandemic in Japan: Results from U-CORONA Study

(2021) Nobutoshi Nawa et al.   International Journal of Environmental Research and Public Health

SARS-CoV-2 evolution and vaccines: cause for concern?

(2021) Thomas C Williams et al.   Lancet Respiratory Medicine

The SARS-CoV-2 Spike variant D614G favors an open conformational state

(2021) Rachael A. Mansbach et al.   Science Advances

How will emerging SARS-CoV-2 variants impact herd immunity?

(2021) Giuseppe Lippi et al.   Annals of Translational Medicine

Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor‐binding domain mutations: Receptor affinity versus neutralization of receptor interaction

(2021) Monique Vogel et al.   ALLERGY

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

(2021) Chang Liu et al.   CELL

Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7 (Alpha), B.1.315 (Beta), and B.1.617.2 (Delta)

(2021) Sean Wei Xiang Ong et al.   CLINICAL INFECTIOUS DISEASES

Increased transmissibility and global spread of SARS-CoV-2 variants of concern as at June 2021

(2021) Finlay Campbell et al.   Eurosurveillance

The incubation period of the SARS-CoV-2 B1.1.7 variant is shorter than that of other strains

(2021) Yoshito Homma et al.   JOURNAL OF INFECTION

Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants

(2021) Charlie Laffeber et al.   JOURNAL OF MOLECULAR BIOLOGY

Neutralization of Beta and Delta variant with sera of COVID-19 recovered cases and vaccinees of inactivated COVID-19 vaccine BBV152/Covaxin

(2021) Pragya D Yadav et al.   JOURNAL OF TRAVEL MEDICINE

CoronaVac: more data for regulators and policy makers

(2021) Maheshi N Ramasamy et al.   LANCET

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised, controlled, phase 1/2 clinical trial

(2021) Bihua Han et al.   LANCET INFECTIOUS DISEASES

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

(2021) Delphine Planas et al.   NATURE

Delta’s rise is fuelled by rampant spread from people who feel fine

(2021) Smriti Mallapaty   NATURE

What the science says about lifting mask mandates

(2021) Lynne Peeples   NATURE

mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar

(2021) Hiam Chemaitelly et al.   NATURE MEDICINE

SARS-CoV-2 variants, spike mutations and immune escape

(2021) William T. Harvey et al.   NATURE REVIEWS MICROBIOLOGY

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

(2021) Paul T. Heath et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma

(2021) Emanuele Andreano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

(2021) Kathryn M. Hastie et al.   SCIENCE

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

(2021) Yongfei Cai et al.   SCIENCE

Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

(2021) Zhiqiang Ku et al.   Nature Communications

Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants

(2021) Satoshi Ikegame et al.   Nature Communications

Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants

(2021) Natália Teruel et al.   PLoS Computational Biology

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

(2021) Marta Alenquer et al.   PLoS Pathogens

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human ACE2 receptor on binding affinity and kinetics

(2021) Michael I Barton et al.   eLife

SARS-CoV-2 Infections and Hospitalizations Among Persons Aged ≥16 Years, by Vaccination Status — Los Angeles County, California, May 1–July 25, 2021

(2021) Jennifer B. Griffin et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Cycle Threshold Probability Score for Immediate and Sensitive Detection of B.1.351 SARS-CoV-2 Lineage

(2021) Dieter De Smet et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections

(2021) Timothy Farinholt et al.   BMC Medicine

Differential Interactions between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern

(2021) Seonghan Kim et al.   Journal of Chemical Theory and Computation

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

(2021) Anika Singanayagam et al.   LANCET INFECTIOUS DISEASES

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

(2021) Jun Zhang et al.   SCIENCE

Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles

(2021) Abdullah M. Syed et al.   SCIENCE

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

(2021) Tadashi Maemura et al.   mBio

Omicron variant and booster COVID-19 vaccines

(2021) Talha Khan Burki   Lancet Respiratory Medicine

A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern

(2021) Mitch Brinkkemper et al.   npj Vaccines

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

(2020) Chunyan Yi et al.   Cellular & Molecular Immunology

SARS-CoV-2 and influenza virus co-infection

(2020) Elena Cuadrado-Payán et al.   LANCET

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Temporal dynamics in viral shedding and transmissibility of COVID-19

(2020) Xi He et al.   NATURE MEDICINE

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

(2020) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

(2020) Qianqian Li et al.   CELL

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)

(2020) W. Joost Wiersinga et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mutations Strengthened SARS-CoV-2 Infectivity

(2020) Jiahui Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

(2020) Ann M. Arvin et al.   NATURE

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

(2020) Alina Baum et al.   SCIENCE

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

(2020) Leonid Yurkovetskiy et al.   CELL

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

(2020) Donald J. Benton et al.   NATURE

Spike mutation D614G alters SARS-CoV-2 fitness

(2020) Jessica A. Plante et al.   NATURE

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

(2020) Jinsung Yang et al.   Nature Communications

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

(2020) Wen Shi Lee et al.   Nature Microbiology

Commentary: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Alexandra Lindsey Zune Djomkam et al.   Frontiers in Oncology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

(2020) Erik Volz et al.   CELL

Co-infection, SARS-CoV-2 and influenza: an evolving puzzle

(2020) Sara Covin et al.   CLINICAL INFECTIOUS DISEASES

ADE and hyperinflammation in SARS-CoV2 infection- comparison with dengue hemorrhagic fever and feline infectious peritonitis

(2020) Maryse Cloutier et al.   CYTOKINE

Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells

(2020) Jian Zheng et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Dynamics Reveals Complex Compensatory Effects of Ionic Strength on the Severe Acute Respiratory Syndrome Coronavirus 2 Spike/Human Angiotensin-Converting Enzyme 2 Interaction

(2020) Anacleto Silva de Souza et al.   Journal of Physical Chemistry Letters

Oxford–AstraZeneca COVID-19 vaccine efficacy

(2020) Maria Deloria Knoll et al.   LANCET

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

(2020) Lizhou Zhang et al.   Nature Communications

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

(2020) Cong Xu et al.   Science Advances

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk

(2013) Romulus Breban et al.   LANCET

A Virus-Binding Hot Spot on Human Angiotensin-Converting Enzyme 2 Is Critical for Binding of Two Different Coronaviruses

(2011) K. Wu et al.   JOURNAL OF VIROLOGY

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Role of Spike Protein Endodomains in Regulating Coronavirus Entry

(2009) Ana Shulla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY