Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

(2020) George Dimopoulos et al.   Cell Host & Microbe

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

(2020) Yang Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Viral and host factors related to the clinical outcome of COVID-19

(2020) Xiaonan Zhang et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Clinical Characteristics of Covid-19 in New York City

(2020) Parag Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

(2020) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?

(2020) Jean-Michel Sallenave et al.   Frontiers in Immunology

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

(2020) Ann M. Arvin et al.   NATURE

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

A molecular pore spans the double membrane of the coronavirus replication organelle

(2020) Georg Wolff et al.   SCIENCE

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

(2020) Chaofu Wang et al.   EBioMedicine

Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction

(2020) Hiroaki Katsura et al.   Cell Stem Cell

Necroptosis restricts influenza A virus as a stand-alone cell death mechanism

(2020) Maria Shubina et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions

(2020) Abdollah Jafarzadeh et al.   LIFE SCIENCES

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preemptive interleukin-6 blockade in patients with COVID-19

(2020) Lucía Guillén et al.   Scientific Reports

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

High Secretion of Interferons by Human Plasmacytoid Dendritic Cells upon Recognition of Middle East Respiratory Syndrome Coronavirus

(2015) Vivian A. Scheuplein et al.   JOURNAL OF VIROLOGY

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response

(2014) Hin Chu et al.   VIROLOGY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

A Human Coronavirus Responsible for the Common Cold Massively Kills Dendritic Cells but Not Monocytes

(2012) M. Mesel-Lemoine et al.   JOURNAL OF VIROLOGY