Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months

An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation

(2022) Corbin E. Goerlich et al.   XENOTRANSPLANTATION

The Growth of Xenotransplanted Hearts Can Be Reduced with Growth Hormone Receptor Knockout Pig Donors

(2021) Corbin E. Goerlich et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation

(2021) Corbin E. Goerlich et al.   Frontiers in Immunology

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

(2020) Takayuki Yamamoto et al.   Scientific Reports

Heterotopic Porcine Cardiac Xenotransplantation in the Intra-Abdominal Position in a Non-Human Primate Model

(2020) Corbin E. Goerlich et al.   Scientific Reports

The desirable donor pig to eliminate all xenoreactive antigens

(2019) Joseph Ladowski et al.   XENOTRANSPLANTATION

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

(2019) David K. C. Cooper et al.   XENOTRANSPLANTATION

LIFE-SUPPORTING KIDNEY XENOTRANSPLANTATION FROM GENETICALLY-ENGINEERED PIGS IN BABOONS

(2019) Takayuki Yamamoto et al.   TRANSPLANTATION

Early experience with preclinical peri-operative cardiac xenograft dysfunction in a single program

(2019) Laura DiChiacchio et al.   ANNALS OF THORACIC SURGERY

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

(2018) Arne Hinrichs et al.   Molecular Metabolism

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs

(2018) Avneesh K. Singh et al.   XENOTRANSPLANTATION

Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression

(2017) Jun-Seop Shin et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report—2014; Focus Theme: Retransplantation

(2014) Lars H. Lund et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells

(2014) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs

(2013) Annegret Wuensch et al.   TRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation

(2010) Guerard W. Byrne et al.   TRANSPLANTATION

Left Ventricular Pressure Measurement by Telemetry Is an Effective Means to Evaluate Transplanted Heart Function in Experimental Heterotopic Cardiac Xenotransplantation

(2010) K.A. Horvath et al.   TRANSPLANTATION PROCEEDINGS

Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons

(2010) Bruce E. Loveland et al.   XENOTRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI

(2008) J. C. Roussel et al.   AMERICAN JOURNAL OF TRANSPLANTATION