Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Porcine antigen-specific IFN-γ ELISpot as a potentially valuable tool for monitoring cellular immune responses in pig-to-non-human primate islet xenotransplantation

(2016) Hyun-Je Kim et al.   XENOTRANSPLANTATION

Induction, management, and complications of streptozotocin-induced diabetes mellitus in rhesus monkeys

(2016) Jong-Min Kim et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Long-Term Control of Diabetes in Immunosuppressed Nonhuman Primates (NHP) by the Transplantation of Adult Porcine Islets

(2015) J. S. Shin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Current status of islet xenotransplantation

(2015) Chung-Gyu Park et al.   International Journal of Surgery

Increase in Anti-Gal IgM Level is Associated With Early Graft Failure in Intraportal Porcine Islet Xenotransplantation

(2015) Hee Jung Kang et al.   Annals of Laboratory Medicine

The Role of the Alternative Complement Pathway in Early Graft Loss After Intraportal Porcine Islet Xenotransplantation

(2014) Hee Jung Kang et al.   TRANSPLANTATION

A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival

(2012) M. Lowe et al.   AMERICAN JOURNAL OF TRANSPLANTATION

T-cell-mediated immunological barriers to xenotransplantation

(2012) Joseph Scalea et al.   XENOTRANSPLANTATION

CD40 Blockade Combines with CTLA4Ig and Sirolimus to Produce Mixed Chimerism in an MHC-Defined Rhesus Macaque Transplant Model

(2011) A. Page et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CD40-Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates

(2011) P. Thompson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Sequential Combination of a JNK Inhibitor and Simvastatin Protects Porcine Islets from Peritransplant Apoptosis and Inflammation

(2011) Sang-Man Jin et al.   CELL TRANSPLANTATION

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Anti-CD40 Monoclonal Antibody Synergizes with CTLA4-Ig in Promoting Long-Term Graft Survival in Murine Models of Transplantation

(2009) C. R. Gilson et al.   JOURNAL OF IMMUNOLOGY

Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model

(2009) G. Hecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parameters for successful pig islet isolation as determined using 68 specific-pathogen-free miniature pigs

(2009) Hyoung-Il Kim et al.   XENOTRANSPLANTATION