DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury

Cytoplasmic DNA: sources, sensing, and role in aging and disease

(2021) Karl N. Miller et al.   CELL

DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis

(2020) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury

(2020) Jin Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Mitochondria in Sepsis-Induced AKI

(2019) Jian Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular nephrology: types of acute tubular injury

(2019) Beatriz Desanti De Oliveira et al.   Nature Reviews Nephrology

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

Salusin-β mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway

(2019) Qing-Bo Lu et al.   Redox Biology

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

(2019) Jin Wang et al.   Redox Biology

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy

(2018) Hao Zhou et al.   CELL DEATH AND DIFFERENTIATION

Melatonin activate FIS1, DYN1 and DYN2 Plasmodium falciparum related-genes for mitochondria fission: mitoemerald-GFP as a tool to visualize mitochondria structure

(2018) Pedro Scarpelli et al.   JOURNAL OF PINEAL RESEARCH

Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage–p53–apoptosis pathway in renal tubular cells

(2018) Huihui Huang et al.   KIDNEY INTERNATIONAL

Mitochondrial dynamics: Biological roles, molecular machinery, and related diseases

(2018) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI

(2017) Heather M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation–induced apoptosis

(2016) Zhenzhen Zhang et al.   FASEB JOURNAL

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

(2016) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation

(2016) Bing Zheng et al.   Scientific Reports

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling

(2015) L. E. Romick-Rosendale et al.   CLINICAL CANCER RESEARCH

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions

(2015) Agnese Cristini et al.   NUCLEIC ACIDS RESEARCH

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase

(2015) Amarjit Mishra et al.   Nature Communications

DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3

(2014) Suzette E. Farber-Katz et al.   CELL

A Phase I Study of DMS612, a Novel Bifunctional Alkylating Agent

(2014) L. J. Appleman et al.   CLINICAL CANCER RESEARCH

Conditional Knockout of Proximal Tubule Mitofusin 2 Accelerates Recovery and Improves Survival after Renal Ischemia

(2014) J. M. Gall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

(2014) Feng Rao et al.   MOLECULAR CELL

Protein Phosphatase 2A and DNA-dependent Protein Kinase Are Involved in Mediating Rapamycin-induced Akt Phosphorylation

(2013) Yikun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-PK Target Identification Reveals Novel Links between DNA Repair Signaling and Cytoskeletal Regulation

(2013) Ewa Kotula et al.   PLoS One

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

(2012) Maria Quanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock protein 90  (HSP90 ), a substrate and chaperone of DNA-PK necessary for the apoptotic response

(2012) S. Solier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation

(2012) M Baritaud et al.   Cell Death & Disease

Effect of hypothermia on doxorubicin-induced cardiac myoblast signaling and cell death

(2011) Thomas J. L'Ecuyer et al.   CARDIOVASCULAR PATHOLOGY

The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation

(2009) Jia Liu et al.   BRAIN RESEARCH

DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1α in hypoxic preconditioned HepG2 cells

(2008) Moon Jung Kang et al.   FEBS Journal

GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

(2008) Yu Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways

(2008) S. Solier et al.   MOLECULAR AND CELLULAR BIOLOGY

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

(2008) E. Huston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA