Protein Phosphatase 2A and DNA-dependent Protein Kinase Are Involved in Mediating Rapamycin-induced Akt Phosphorylation

Mcl-1 Ubiquitination and Destruction

(2015) Hiroyuki Inuzuka et al.   Oncotarget

A Nonhomologous End-joining Pathway Is Required for Protein Phosphatase 2A Promotion of DNA Double-Strand Break Repair

(2015) Qinhong Wang et al.   NEOPLASIA

PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors

(2012) F. Meric-Bernstam et al.   CLINICAL CANCER RESEARCH

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

(2012) Maria Quanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Activity of NVP-BKM120--A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells

(2011) D. Koul et al.   CLINICAL CANCER RESEARCH

Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

(2011) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors’ anticancer efficacy

(2010) Xuerong Wang et al.   CANCER BIOLOGY & THERAPY

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

(2010) Richard Hill et al.   CELL CYCLE

The mTOR Inhibitor Rapamycin Suppresses DNA Double-Strand Break Repair

(2010) Honghong Chen et al.   RADIATION RESEARCH

Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy

(2009) Tomohiro Yorimitsu et al.   Autophagy

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PIKKing on PKB: regulation of PKB activity by phosphorylation

(2009) Lana Bozulic et al.   CURRENT OPINION IN CELL BIOLOGY

Inactivation of Mammalian Target of Rapamycin Increases STAT1 Nuclear Content and Transcriptional Activity in α4- and Protein Phosphatase 2A-dependent Fashion

(2009) Jill A. Fielhaber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif

(2009) Jongsun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Nuclear Proteomics Identifies mTOR Regulation of DNA Damage Response

(2009) Sricharan Bandhakavi et al.   MOLECULAR & CELLULAR PROTEOMICS

New Insights into mTOR Signaling: mTORC2 and Beyond

(2009) D. R. Alessi et al.   Science Signaling

Rapamycin Inhibits Yeast Nucleotide Excision Repair Independently of Tor Kinases

(2009) Melvin V. Limson et al.   TOXICOLOGICAL SCIENCES

Enhancing Mammalian Target of Rapamycin (mTOR)-Targeted Cancer Therapy by Preventing mTOR/Raptor Inhibition-Initiated, mTOR/Rictor-Independent Akt Activation

(2008) X. Wang et al.   CANCER RESEARCH

In VivoAnalysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

(2008) Banu Surucu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

(2008) E. Huston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

(2008) K. A. Boehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple pathways regulated by the tumor suppressor PP2A in transformation

(2008) Jukka Westermarck et al.   TRENDS IN MOLECULAR MEDICINE