Superconserved receptors expressed in the brain: Expression, function, motifs and evolution of an orphan receptor family

Development of novel potent ligands for GPR85 , an orphan G protein‐coupled receptor expressed in the brain

(2022) Aya Sakai et al.   GENES TO CELLS

Classification Model for the Second Extracellular Loop of Class A GPCRs

(2022) Alessandro Nicoli et al.   Journal of Chemical Information and Modeling

Premetazoan Origin of Neuropeptide Signaling

(2022) Luis Alfonso Yañez-Guerra et al.   MOLECULAR BIOLOGY AND EVOLUTION

GPR27 Regulates Hepatocellular Carcinoma Progression via MAPK/ERK Pathway

(2022) Hongxv Wang et al.   Cancer Management and Research

The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3 Embryonic Cells and Astrocytes

(2022) Dorian Dolanc et al.   Cells

Constitutive G protein coupling profiles of understudied orphan GPCRs

(2021) Sumin Lu et al.   PLoS One

New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation

(2021) Sandra Berndt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Deconstructing the transmembrane core of class A G protein–coupled receptors

(2021) Steven O. Smith   TRENDS IN BIOCHEMICAL SCIENCES

Characterization of the G protein-coupled receptor family SREB across fish evolution

(2021) Timothy S. Breton et al.   Scientific Reports

Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27

(2021) Thanigaimalai Pillaiyar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GPCR activation mechanisms across classes and macro/microscales

(2021) Alexander S. Hauser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors

(2020) Raise Ahmad et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins—In Silico Study

(2020) Justyna Żuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis of ligand recognition and self-activation of orphan GPR52

(2020) Xi Lin et al.   NATURE

Hermaphroditism in fishes: an annotated list of species, phylogeny, and mating system

(2020) Tetsuo Kuwamura et al.   ICHTHYOLOGICAL RESEARCH

Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes

(2020) Deeksha G. Chopra et al.   Scientific Reports

Structural features of activated GPCR signaling complexes

(2020) Jingjing Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

GPCRdb in 2021: integrating GPCR sequence, structure and function

(2020) Albert J Kooistra et al.   NUCLEIC ACIDS RESEARCH

Assembly of a GPCR-G Protein Complex

(2019) Yang Du et al.   CELL

Molecular switches in GPCRs

(2019) Slawomir Filipek   CURRENT OPINION IN STRUCTURAL BIOLOGY

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

Extramembranous Regions in G Protein-Coupled Receptors: Cinderella in Receptor Biology?

(2019) Sreetama Pal et al.   JOURNAL OF MEMBRANE BIOLOGY

Harnessing Ion-Binding Sites for GPCR Pharmacology

(2019) Barbara Zarzycka et al.   PHARMACOLOGICAL REVIEWS

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

(2019) Simon R. Foster et al.   CELL

Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish

(2019) Anjali K. Nath et al.   FASEB JOURNAL

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists

(2018) Martyna Szpakowska et al.   BIOCHEMICAL PHARMACOLOGY

The G protein-coupled receptors deorphanization landscape

(2018) Céline Laschet et al.   BIOCHEMICAL PHARMACOLOGY

Orphan G protein-coupled receptors: The role in CNS disorders

(2018) Mohaddeseh Sadat Alavi et al.   BIOMEDICINE & PHARMACOTHERAPY

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A 2A Adenosine Receptor

(2018) Matthew T. Eddy et al.   CELL

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

(2018) Sheng Wang et al.   NATURE

Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

(2018) Chunmei Jin et al.   Frontiers in Molecular Neuroscience

Differential Gene Expression Associated with Meningeal Injury in Acute Mild Traumatic Brain Injury

(2017) Whitney S. Livingston et al.   JOURNAL OF NEUROTRAUMA

Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family

(2017) Michael J. Woolley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate Ligands Promotes β -Arrestin 2 Recruitment

(2017) Nadine Dupuis et al.   MOLECULAR PHARMACOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

(2017) Andrii Ishchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D4dopamine receptor high-resolution structures enable the discovery of selective agonists

(2017) Sheng Wang et al.   SCIENCE

Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173

(2016) Lauren M. Stein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

(2016) Toshihiro Yanai et al.   GENES TO CELLS

Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173

(2016) Alice K. Treen et al.   MOLECULAR ENDOCRINOLOGY

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

(2016) A. J. Venkatakrishnan et al.   NATURE

Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

(2016) Md. Shamim Hossain et al.   PLoS One

Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer

(2015) Malin Lando et al.   Epigenetics

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily

(2015) Bryan L. Roth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GPCRdb: an information system for G protein-coupled receptors

(2015) Vignir Isberg et al.   NUCLEIC ACIDS RESEARCH

Neurogenesis in the Adult Hippocampus

(2015) Gerd Kempermann et al.   Cold Spring Harbor Perspectives in Biology

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Time since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue

(2015) Cornelia A. M. van de Weg et al.   PLoS Neglected Tropical Diseases

The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis

(2015) Eriko Fujita-Jimbo et al.   Molecular Autism

Subgroup-Elimination Transcriptomics Identifies Signaling Proteins that Define Subclasses of TRPV1-Positive Neurons and a Novel Paracrine Circuit

(2015) Jörg Isensee et al.   PLoS One

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

(2015) Adam L. Martin et al.   PLoS One

Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II

(2014) Francesca Magnani et al.   ACS Chemical Biology

MoDPepInt: an interactive web server for prediction of modular domain–peptide interactions

(2014) Kousik Kundu et al.   BIOINFORMATICS

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors

(2014) Kavita Kumari Kakarala et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Modulation of GPCRs by monovalent cations and anions

(2014) Andrea Strasser et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Closing the Ring: A Fourth Extracellular Loop in Chemokine Receptors

(2014) M. Szpakowska et al.   Science Signaling

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes

(2014) Shengfeng Huang et al.   Nature Communications

Effects of cadmium on olfactory mediated behaviors and molecular biomarkers in coho salmon (Oncorhynchus kisutch)

(2013) Chase R. Williams et al.   AQUATIC TOXICOLOGY

β-Arrestin 2 Is a Mediator of GnRH-(1–5) Signaling in Immortalized GnRH Neurons

(2013) Darwin O. Larco et al.   ENDOCRINOLOGY

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

(2013) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

(2013) Maja S. Engelstoft et al.   Molecular Metabolism

The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor

(2013) Darwin Omar Larco et al.   Frontiers in Endocrinology

Lifting the lid on GPCRs: the role of extracellular loops

(2012) M Wheatley et al.   BRITISH JOURNAL OF PHARMACOLOGY

Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies

(2012) B. Trzaskowski et al.   CURRENT MEDICINAL CHEMISTRY

SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory

(2012) Qian Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effect of Schizophrenia Risk-Associated Alleles in SREB2 (GPR85) on Functional MRI Phenotypes in Healthy Volunteers

(2012) Eugenia Radulescu et al.   NEUROPSYCHOPHARMACOLOGY

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production

(2012) Gregory M. Ku et al.   PLoS Genetics

G Protein–Coupled Receptor Deorphanizations

(2011) Olivier Civelli et al.   Annual Review of Pharmacology and Toxicology

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural insights into agonist-induced activation of G-protein-coupled receptors

(2011) Xavier Deupi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hagfish, Genome Duplications, and RFamide Neuropeptide Evolution

(2011) Robert M. Dores   ENDOCRINOLOGY

Translocation breakpoint at 7q31 associated with tics: further evidence for IMMP2L as a candidate gene for Tourette syndrome

(2011) Chirag Patel et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The origin and evolution of vertebrate sex chromosomes and dosage compensation

(2011) A M Livernois et al.   HEREDITY

Too many roads not taken

(2011) Aled M. Edwards et al.   NATURE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Evolution of GPCR: Change and continuity

(2010) Rainer Strotmann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice

(2009) Junko Ito et al.   CELL AND TISSUE RESEARCH

A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis

(2009) Mitchel J. Pariani et al.   European Journal of Medical Genetics

A Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors

(2009) Birgitte Holst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study

(2008) Richard J.L. Anney et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A Second Disulfide Bridge from the N-Terminal Domain to Extracellular Loop 2 Dampens Receptor Activity in GPR39†

(2008) Laura Storjohann et al.   BIOCHEMISTRY

Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts

(2008) Sebastien Ribrioux et al.   BMC GENOMICS

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Early crest animals and the insight they provide into the evolutionary origin of craniates

(2008) Jun-Yuan Chen   GENESIS

The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia

(2008) M. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE