The Emerging Role of Mechanics in Synapse Formation and Plasticity

Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry

(2018) Philipp Schätzle et al.   CURRENT BIOLOGY

Dynamics, nanoscale organization, and function of synaptic adhesion molecules

(2018) Ingrid Chamma et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nanoparticles for super-resolution microscopy and single-molecule tracking

(2018) Dayong Jin et al.   NATURE METHODS

Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase

(2018) Yu-Ting Mao et al.   NEURON

Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships

(2018) Peng Zhang et al.   CELL

Cofilin Rods and Aggregates Concur with Tau Pathology and the Development of Alzheimer's Disease

(2018) Tasnim Rahman et al.   JOURNAL OF ALZHEIMERS DISEASE

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

(2017) Jordano Brito-Moreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

(2017) A. C. Penn et al.   NATURE

Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning

(2017) Fergil Mills et al.   NATURE NEUROSCIENCE

Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus

(2017) Raunak Basu et al.   NEURON

Neuronal Cell Bodies Remotely Regulate Axonal Growth Response to Localized Netrin-1 Treatment via Second Messenger and DCC Dynamics

(2017) Agata Blasiak et al.   Frontiers in Cellular Neuroscience

Neurofilaments and Neurofilament Proteins in Health and Disease

(2017) Aidong Yuan et al.   Cold Spring Harbor Perspectives in Biology

Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs

(2017) Jinwei Zhu et al.   Cell Reports

Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix

(2017) Monika Bijata et al.   Cell Reports

Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity

(2017) Susann Ludewig et al.   Frontiers in Molecular Neuroscience

The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer’s disease

(2016) Phillip R. Gordon-Weeks   BRAIN RESEARCH BULLETIN

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

The mechanical regulation of integrin–cadherin crosstalk organizes cells, signaling and forces

(2016) Keeley L. Mui et al.   JOURNAL OF CELL SCIENCE

Guidance of Axons by Local Coupling of Retrograde Flow to Point Contact Adhesions

(2016) R. H. Nichol et al.   JOURNAL OF NEUROSCIENCE

The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing

(2016) E. F. Spence et al.   JOURNAL OF NEUROSCIENCE

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

(2016) Mehtap Bacioglu et al.   NEURON

Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B

(2016) Amy E. Ghiretti et al.   NEURON

Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons

(2016) Csaba Földy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells

(2016) Sabine Fièvre et al.   Nature Communications

Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity

(2016) Derrick P. McVicker et al.   Nature Communications

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

(2016) Mary Muhia et al.   Cell Reports

APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone

(2016) Melanie Laßek et al.   PLoS Computational Biology

Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease

(2016) Holly Stefen et al.   NEURAL PLASTICITY

Periodic F-actin structures shape the neck of dendritic spines

(2016) Julia Bär et al.   Scientific Reports

Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes

(2015) Wen-Jie Bian et al.   CELL

Coordinating Neuronal Actin–Microtubule Dynamics

(2015) Charlotte H. Coles et al.   CURRENT BIOLOGY

The Regulation of Synaptic Protein Turnover

(2015) Beatriz Alvarez-Castelao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

(2015) Karen A. Newell-Litwa et al.   JOURNAL OF CELL BIOLOGY

Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines

(2015) Anaël Chazeau et al.   MOLECULAR BIOLOGY OF THE CELL

Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo

(2015) A Yuan et al.   MOLECULAR PSYCHIATRY

Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3

(2015) Martin Hruska et al.   NATURE NEUROSCIENCE

Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains

(2015) Karen Perez de Arce et al.   NEURON

Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity

(2015) John M. Nicoludis et al.   STRUCTURE

Emerging properties of adhesion complexes: what are they and what do they do?

(2015) Jonathan D. Humphries et al.   TRENDS IN CELL BIOLOGY

Towards a Dynamic Understanding of Cadherin-Based Mechanobiology

(2015) Brenton D. Hoffman et al.   TRENDS IN CELL BIOLOGY

Mechanochemical regulation of growth cone motility

(2015) Patrick C. Kerstein et al.   Frontiers in Cellular Neuroscience

Microtechnologies for studying the role of mechanics in axon growth and guidance

(2015) Devrim Kilinc et al.   Frontiers in Cellular Neuroscience

Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer’s disease

(2015) Iryna Leshchyns’ka et al.   Nature Communications

Cadherins and catenins in dendrite and synapse morphogenesis

(2015) Eunju Seong et al.   Cell Adhesion & Migration

Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions

(2015) Wei Hu et al.   Biomed Research International

Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function

(2015) Dimitar Kostadinov et al.   eLife

Cadherin Adhesion and Mechanotransduction

(2014) D.E. Leckband et al.   Annual Review of Cell and Developmental Biology

How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors

(2014) Anna-Lena Cost et al.   Cellular and Molecular Bioengineering

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion

(2014) Anaël Chazeau et al.   EMBO JOURNAL

SynCAMs extend their functions beyond the synapse

(2014) Jeannine A. Frei et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Structural and Thermodynamic Characterization of Cadherin·β-Catenin·α-Catenin Complex Formation

(2014) Sabine Pokutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Presynaptic and Postsynaptic Scaffolds

(2014) Noam E. Ziv et al.   NEUROSCIENTIST

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood

(2014) Aaron D. Levy et al.   Frontiers in Neuroanatomy

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

The mechanical control of nervous system development

(2013) K. Franze   DEVELOPMENT

Dynein Interacts with the Neural Cell Adhesion Molecule (NCAM180) to Tether Dynamic Microtubules and Maintain Synaptic Density in Cortical Neurons

(2013) Eran Perlson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses

(2013) Michael A Bemben et al.   NATURE NEUROSCIENCE

Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1

(2013) Grégory Giannone et al.   Cell Reports

C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β

(2012) Aksana Andreyeva et al.   BRAIN

Dynamics of presynaptic protein recruitment induced by local presentation of artificial adhesive contacts

(2012) Fernando Suarez et al.   Developmental Neurobiology

Polarization of actin cytoskeleton is reduced in dendritic protrusions during early spine development in hippocampal neuron

(2012) Vedakumar Tatavarty et al.   MOLECULAR BIOLOGY OF THE CELL

Microdomains in Forebrain Spines: an Ultrastructural Perspective

(2012) Bence Rácz et al.   MOLECULAR NEUROBIOLOGY

Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1

(2012) Rui T. Peixoto et al.   NEURON

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

Cofilin under control of  -arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning

(2012) C. G. Pontrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-interface is not the explanation for the slow disassembly of N-cadherin dimers in the apo state

(2012) Nagamani Vunnam et al.   PROTEIN SCIENCE

Use the force: membrane tension as an organizer of cell shape and motility

(2012) Alba Diz-Muñoz et al.   TRENDS IN CELL BIOLOGY

Structural plasticity of dendritic spines

(2011) Miquel Bosch et al.   CURRENT OPINION IN NEUROBIOLOGY

Casting a net on dendritic spines: The extracellular matrix and its receptors

(2011) Lorraine E. Dansie et al.   Developmental Neurobiology

N-Methyl-d-aspartate Receptor Mechanosensitivity Is Governed by C Terminus of NR2B Subunit

(2011) Pallab Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production

(2011) Megumi Asada-Utsugi et al.   JOURNAL OF NEUROCHEMISTRY

NMDA Receptor Activation Suppresses Microtubule Growth and Spine Entry

(2011) L. C. Kapitein et al.   JOURNAL OF NEUROSCIENCE

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

(2011) Hideji Murakoshi et al.   NATURE

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Syntaxin-4 Defines a Domain for Activity-Dependent Exocytosis in Dendritic Spines

(2010) Matthew J. Kennedy et al.   CELL

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin

(2010) O. Bozdagi et al.   JOURNAL OF NEUROSCIENCE

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

Neurexin-Neuroligin Cell Adhesion Complexes Contribute to Synaptotropic Dendritogenesis via Growth Stabilization Mechanisms In Vivo

(2010) Simon Xuan Chen et al.   NEURON

Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines

(2010) Nicholas A. Frost et al.   NEURON

N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth

(2010) Z.-J. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Coincident Pre- and Postsynaptic Activation Induces Dendritic Filopodia via Neurotrypsin-Dependent Agrin Cleavage

(2009) Kazumasa Matsumoto-Miyai et al.   CELL

Different Rho GTPase–dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

(2009) Christopher S. Rex et al.   JOURNAL OF CELL BIOLOGY

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Myosin Vb Mobilizes Recycling Endosomes and AMPA Receptors for Postsynaptic Plasticity

(2008) Zhiping Wang et al.   CELL

Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines

(2008) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Bidirectional modulation of synaptic functions by Eph/ephrin signaling

(2008) Rüdiger Klein   NATURE NEUROSCIENCE

Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation

(2008) Susana S Correia et al.   NATURE NEUROSCIENCE

A Role for Local Calcium Signaling in Rapid Synaptic Partner Selection by Dendritic Filopodia

(2008) Christian Lohmann et al.   NEURON

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

(2008) Naoki Honkura et al.   NEURON

Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins

(2008) Lorenzo A. Cingolani et al.   NEURON