The Cuprizone Model: Dos and Do Nots

Evaluation strategy to determine reliable demyelination in the cuprizone model

(2019) Uta Chrzanowski et al.   METABOLIC BRAIN DISEASE

Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action

(2019) Newshan Behrangi et al.   Cells

Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models

(2019) Anne Nack et al.   Cells

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

(2019) Alexandra M. Nicaise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors

(2019) Roey Baror et al.   GLIA

Animal Weight Is an Important Variable for Reliable Cuprizone-Induced Demyelination

(2019) Patrizia Leopold et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

(2019) Rhonda R. Voskuhl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

(2019) Maria L. Elkjaer et al.   Acta Neuropathologica Communications

High Speed Ventral Plane Videography as a Convenient Tool to Quantify Motor Deficits during Pre-Clinical Experimental Autoimmune Encephalomyelitis

(2019) Zhan et al.   Cells

From OPC to Oligodendrocyte: An Epigenetic Journey

(2019) Assia Tiane et al.   Cells

The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE)

(2018) Christopher Bolton et al.   AGEING RESEARCH REVIEWS

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone-induced demyelination

(2018) Yochai Wolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical Approach

(2018) Sebastian Rühling et al.   MOLECULAR NEUROBIOLOGY

Unravelling molecular complexity in structural cell biology

(2018) Stefan Pfeffer et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3

(2018) Felix Fischbach et al.   GLIA

Multiple sclerosis

(2018) Massimo Filippi et al.   Nature Reviews Disease Primers

Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

(2017) Bernhard Josef Rüther et al.   GLIA

Cuprizone-Containing Pellets Are Less Potent to Induce Consistent Demyelination in the Corpus Callosum of C57BL/6 Mice

(2017) Tanja Hochstrasser et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis

(2017) Shailender Singh et al.   Journal of Neuroinflammation

Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex

(2017) D. Carassiti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Investigation of Cuprizone Inactivation by Temperature

(2017) Sandra Heckers et al.   NEUROTOXICITY RESEARCH

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

(2017) Stefan A. Berghoff et al.   Acta Neuropathologica Communications

Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach

(2016) Katharina Marie Höflich et al.   BRAIN RESEARCH

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

(2016) Kim Ohl et al.   EXPERIMENTAL NEUROLOGY

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model

(2016) T. Draheim et al.   GLIA

Thalamus Degeneration and Inflammation in Two Distinct Multiple Sclerosis Animal Models

(2016) Nina Wagenknecht et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain

(2016) M. Scheld et al.   JOURNAL OF NEUROSCIENCE

Functional reorganization is a maladaptive response to injury – NO

(2016) Iris-Katharina Penner et al.   Multiple Sclerosis Journal

Functional reorganization is a maladaptive response to injury – NO

(2016) Iris-Katharina Penner et al.   Multiple Sclerosis Journal

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

(2015) Tanja Jürgens et al.   BRAIN

Animal models of Multiple Sclerosis

(2015) Claudio Procaccini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Remyelination strategies in multiple sclerosis: a critical reflection

(2015) Markus Kipp   Expert Review of Neurotherapeutics

Anatomical Distribution of Cuprizone-Induced Lesions in C57BL6 Mice

(2015) Johannes Goldberg et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions

(2015) René Große-Veldmann et al.   MOLECULAR NEUROBIOLOGY

Longitudinal fMRI studies: Exploring brain plasticity and repair in MS

(2015) Christian Enzinger et al.   Multiple Sclerosis Journal

Remyelination strategies in multiple sclerosis: a critical reflection

(2015) Markus Kipp   Expert Review of Neurotherapeutics

Longitudinal fMRI studies: Exploring brain plasticity and repair in MS

(2015) Christian Enzinger et al.   Multiple Sclerosis Journal

Region and dynamic specificities of adult neural stem cells and oligodendrocyte precursors in myelin regeneration in the mouse brain

(2015) B. Brousse et al.   Biology Open

The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination

(2014) A Slowik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gender influence on schizophrenia-relevant abnormalities in a cuprizone demyelination model

(2014) Brenda Valeiras et al.   GLIA

Short-Term Cuprizone Feeding Verifies N-Acetylaspartate Quantification as a Marker of Neurodegeneration

(2014) Barbara Maria Krauspe et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Secretome Analysis of Human Oligodendrocytes Derived from Neural Stem Cells

(2014) Woo Kyung Kim et al.   PLoS One

Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons

(2014) Nobuhiko Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

APC binds intermediate filaments and is required for their reorganization during cell migration

(2013) Yasuhisa Sakamoto et al.   JOURNAL OF CELL BIOLOGY

Cuprizone-Induced Demyelination as a Tool to Study Remyelination and Axonal Protection

(2013) Adib Zendedel et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Epigenome-wide differences in pathology-free regions of multiple sclerosis–affected brains

(2013) Jimmy L Huynh et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination

(2013) Jonathan D. Thiessen et al.   NMR IN BIOMEDICINE

The cuprizone model: regional heterogeneity of pathology

(2012) Stig Wergeland et al.   APMIS

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

(2012) Tim Clarner et al.   GLIA

Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic Modulation via Fumaric Acid Esters

(2012) De-Hyung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regional Heterogeneity of Cuprizone-Induced Demyelination: Topographical Aspects of the Midline of the Corpus Callosum

(2012) T. Schmidt et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inflammatory Response and Chemokine Expression in the White Matter Corpus Callosum and Gray Matter Cortex Region During Cuprizone-Induced Demyelination

(2012) J. P. Buschmann et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Unknown

(2012) Nora Hagemeyer et al.   MOLECULAR MEDICINE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Animal models of multiple sclerosis: the good, the bad and the bottom line

(2012) Richard M Ransohoff   NATURE NEUROSCIENCE

Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis

(2011) Natalia Manrique-Hoyos et al.   ANNALS OF NEUROLOGY

BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions

(2011) M. Kipp et al.   BRAIN BEHAVIOR AND IMMUNITY

Axonal Damage in Multiple Sclerosis

(2011) Jeffery D. Haines et al.   MOUNT SINAI JOURNAL OF MEDICINE

Lack of cuprizone-induced demyelination in the murine spinal cord despite oligodendroglial alterations substantiates the concept of site-specific susceptibilities of the central nervous system

(2011) V. Herder et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

(2011) Andrew J. Steelman et al.   NEUROSCIENCE RESEARCH

Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination

(2011) Mangala M. Soundarapandian et al.   Scientific Reports

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients

(2010) Ranjan Dutta et al.   ANNALS OF NEUROLOGY

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics

(2010) Haiyun Xu   Frontiers in Behavioral Neuroscience

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Diffusely Abnormal White Matter in Progressive Multiple Sclerosis: In Vivo Quantitative MR Imaging Characterization and Comparison between Disease Types

(2009) H. Vrenken et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cuprizone Demyelination of the Corpus Callosum in Mice Correlates with Altered Social Interaction and Impaired Bilateral Sensorimotor Coordination

(2009) Norah Hibbits et al.   ASN Neuro

Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.

(2009) Haiyun Xu et al.   BEHAVIORAL NEUROSCIENCE

SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination

(2009) Lorelei C. Taylor et al.   BRAIN PATHOLOGY

Cerebellar Cortical Demyelination in the Murine Cuprizone Model

(2009) Thomas Skripuletz et al.   BRAIN PATHOLOGY

Cuprizone Treatment Induces Distinct Demyelination, Astrocytosis, and Microglia Cell Invasion or Proliferation in the Mouse Cerebellum

(2009) Angela Groebe et al.   CEREBELLUM

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

Expression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Rat

(2009) Ha Na Lee et al.   NEUROCHEMICAL RESEARCH

Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

(2009) Maren Lindner et al.   NEUROSCIENCE LETTERS

Demyelination in the juvenile period, but not in adulthood, leads to long-lasting cognitive impairment and deficient social interaction in mice

(2009) Manabu Makinodan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The cuprizone model for demyelination

(2008) Ø. Torkildsen et al.   ACTA NEUROLOGICA SCANDINAVICA

Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent

(2008) Thomas Skripuletz et al.   AMERICAN JOURNAL OF PATHOLOGY

MHC class II exacerbates demyelination in vivo independently of T cells

(2008) Meenaxi M. Hiremath et al.   JOURNAL OF NEUROIMMUNOLOGY

Relapses in multiple sclerosis are age- and time-dependent

(2008) H Tremlett et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY