Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases

Monocyte-derived S1P in the lymph node regulates immune responses

(2021) Audrey Baeyens et al.   NATURE

Incidence and Risk of Infection Associated With Fingolimod in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis of 8,448 Patients From 12 Randomized Controlled Trials

(2021) Zhao Zhao et al.   Frontiers in Immunology

The Treatment of Lung Involvement in Systemic Sclerosis

(2021) Barbara Ruaro et al.   Pharmaceuticals

Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis

(2021) Tamara Pérez-Jeldres et al.   DRUGS

Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts

(2021) Jeonghyeon Moon et al.   Journal of Translational Medicine

All-cause and Cause-specific Mortality in Systemic Lupus Erythematosus: A Population-based Study

(2021) Bahar Moghaddam et al.   RHEUMATOLOGY

Deletion of Mfsd2b impairs thrombotic functions of platelets

(2021) Madhuvanthi Chandrakanthan et al.   Nature Communications

FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes

(2021) Chao Zhu et al.   Drug Design Development and Therapy

RNA externalized by neutrophil extracellular traps promotes inflammatory pathways in endothelial cells

(2021) Luz P. Blanco et al.   Arthritis & Rheumatology

Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis

(2021) Thijs J. Sluiter et al.   Biomedicines

Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-Induced Pulmonary Fibrosis

(2021) Rachel S Knipe et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

(2021) Marisa P McGinley et al.   LANCET

Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management

(2021) Suha Kadura et al.   European Respiratory Review

Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization

(2020) Keisuke Yanagida et al.   DEVELOPMENTAL CELL

Treatment effects of fingolimod in multiple sclerosis: Selective changes in peripheral blood lymphocyte subsets

(2020) Maria Hjorth et al.   PLoS One

Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy

(2020) Andreane Cartier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-treatment T-cell subsets associate with fingolimod treatment responsiveness in multiple sclerosis

(2020) Mahtab Ghadiri et al.   Scientific Reports

Lupus nephritis

(2020) Hans-Joachim Anders et al.   Nature Reviews Disease Primers

The Role of TH17 Cells in Multiple Sclerosis: Therapeutic Implications

(2020) Tobias Moser et al.   AUTOIMMUNITY REVIEWS

Roles for lysophosphatidic acid signaling in vascular development and disease

(2020) Susan S. Smyth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Update on the cellular and molecular aspects of lupus nephritis

(2020) Eleni Frangou et al.   CLINICAL IMMUNOLOGY

Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair

(2020) Bi-Sen Ding et al.   DEVELOPMENTAL CELL

Effect of the sphingosine-1-phosphate receptor modulator ozanimod on leukocyte subtypes in relapsing MS

(2020) Sarah Harris et al.   Neurology-Neuroimmunology & Neuroinflammation

Lysolipids in Vascular Development, Biology, and Disease

(2020) Eric Engelbrecht et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial dysfunction and cardiovascular risk in lupus nephritis: New roles for old players?

(2020) Daniele Mancardi et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

(2020) Maya H. Buch et al.   Nature Reviews Rheumatology

Attenuation of murine sclerodermatous models by the selective S1P1 receptor modulator cenerimod

(2019) Miyu Kano et al.   Scientific Reports

Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin

(2019) Brian J. Laidlaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis

(2019) Jing Jin et al.   Frontiers in Pharmacology

Autoreactive B cells in SLE, villains or innocent bystanders?

(2019) Jennie A. Hamilton et al.   IMMUNOLOGICAL REVIEWS

Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus

(2019) Sammy Patyna et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

TH17 cells expressing CD146 are significantly increased in patients with Systemic sclerosis

(2019) Amira Gabsi et al.   Scientific Reports

Infection Risks Among Patients With Multiple Sclerosis Treated With Fingolimod, Natalizumab, Rituximab, and Injectable Therapies

(2019) Gustavo Luna et al.   JAMA Neurology

Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models

(2019) Kunio Sugahara et al.   Journal of Immunology Research

FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus

(2018) Dongyan Shi et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting interferons as a strategy for systemic sclerosis treatment

(2018) Marzena Ciechomska et al.   IMMUNOLOGY LETTERS

S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate

(2018) Annabelle Drouillard et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus

(2018) Kristen R. Taylor Meadows et al.   PLoS One

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

(2018) Marie Dominique Ah Kioon et al.   Science Translational Medicine

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

(2018) Christina Christoffersen et al.   Cell Reports

Sphingosine -1 Phosphate Receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury

(2018) Nathalie Burg et al.   Arthritis & Rheumatology

Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus

(2018) Takayuki Katsuyama et al.   Frontiers in Immunology

IL-1-IL-17 Signaling Axis Contributes to Fibrosis and Inflammation in Two Different Murine Models of Systemic Sclerosis

(2018) Min-Jung Park et al.   Frontiers in Immunology

Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo

(2018) Margarita Dominguez-Villar et al.   JOURNAL OF AUTOIMMUNITY

Major lung complications of systemic sclerosis

(2018) Christopher P. Denton et al.   Nature Reviews Rheumatology

Vascular Leaking, a Pivotal and Early Pathogenetic Event in Systemic Sclerosis: Should the Door Be Closed?

(2018) Cosimo Bruni et al.   Frontiers in Immunology

Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling

(2018) Elise V. Mike et al.   Frontiers in Immunology

Mortality in systemic lupus erythematosus: causes, predictors and interventions

(2018) Vanessa Ocampo-Piraquive et al.   Expert Review of Clinical Immunology

Myocardial Inflammation, Measured Using 18-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET-CT) is Associated with Disease Activity in Rheumatoid Arthritis

(2018) Isabelle Amigues et al.   Arthritis & Rheumatology

Regulatory T Cells in Systemic Sclerosis

(2018) Camelia Frantz et al.   Frontiers in Immunology

S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and PressureNovelty and Significance

(2017) Anna Cantalupo et al.   HYPERTENSION

Low apolipoprotein M serum levels correlate with Systemic lupus erythematosus disease activity and apolipoprotein M gene polymorphisms with Lupus

(2017) Wenhan Du et al.   Lipids in Health and Disease

Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study

(2017) A Checa et al.   LUPUS

S1P1Modulator-Induced GαiSignaling andβ-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

(2017) Magdalena Birker-Robaczewska et al.   MOLECULAR PHARMACOLOGY

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unchanging premature mortality trends in systemic lupus erythematosus: a general population-based study (1999–2014)

(2017) April M Jorge et al.   RHEUMATOLOGY

An engineered S1P chaperone attenuates hypertension and ischemic injury

(2017) Steven L. Swendeman et al.   Science Signaling

Sphingosine-1-Phosphate

(2017) Martin S. Winkler et al.   SHOCK

An engineered S1P chaperone attenuates hypertension and ischemic injury

(2017) Steven L. Swendeman et al.   Science Signaling

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study

(2017) Katrin G. Schmidt et al.   Frontiers in Immunology

Sphingosine-1-Phosphate Promotes the Persistence of Activated CD4 T Cells in Inflamed Sites

(2017) Shafqat Ahrar Jaigirdar et al.   Frontiers in Immunology

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

(2017) Marc Bigaud et al.   PLoS One

Sphingosine 1-phosphate receptor 1 (S1PR1) agonist CYM5442 inhibits expression of intracellular adhesion molecule 1 (ICAM1) in endothelial cells infected with influenza A viruses

(2017) Hao Jiang et al.   PLoS One

S1P1 deletion differentially affects TH17 and Regulatory T cells

(2017) Ahmet Eken et al.   Scientific Reports

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1Highlights

(2016) Mario Ruiz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk

(2016) Kunio Sugahara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development

(2016) Ishita Chatterjee et al.   CARDIOVASCULAR RESEARCH

Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic ShockNovelty and Significance

(2016) Salomé L. Gazit et al.   CIRCULATION RESEARCH

Impaired endothelial barrier function in apolipoprotein M–deficient mice is dependent on sphingosine-1-phosphate receptor 1

(2016) Pernille M. Christensen et al.   FASEB JOURNAL

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells and endothelium and modulated during inflammatory bowel disease

(2016) T Karuppuchamy et al.   Mucosal Immunology

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

(2016) Nathan Pankratz et al.   NATURE GENETICS

S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification

(2016) John R. Teijaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial

(2016) Donald P Tashkin et al.   Lancet Respiratory Medicine

Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury

(2015) Matthew L. Stone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

(2015) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In VivoNovelty and Significance

(2015) Nicole Urtz et al.   CIRCULATION RESEARCH

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes

(2015) Yanping Han et al.   JOURNAL OF IMMUNOLOGY

Fingolimod does not impair T-cell release from the thymus and beneficially affects Treg function in patients with multiple sclerosis

(2015) Jürgen Haas et al.   Multiple Sclerosis Journal

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

(2015) Victoria A. Blaho et al.   NATURE

A map of the distribution of sphingosine 1-phosphate in the spleen

(2015) Willy D Ramos-Perez et al.   NATURE IMMUNOLOGY

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Fingolimod does not impair T-cell release from the thymus and beneficially affects Treg function in patients with multiple sclerosis

(2015) Jürgen Haas et al.   Multiple Sclerosis Journal

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

(2014) John Camm et al.   AMERICAN HEART JOURNAL

Mice With Targeted Inactivation of Ppap2b in Endothelial and Hematopoietic Cells Display Enhanced Vascular Inflammation and Permeability

(2014) Manikandan Panchatcharam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Granule-mediated release of sphingosine-1-phosphate by activated platelets

(2014) Deepa Jonnalagadda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1receptor internalization

(2014) David A Sykes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulatory T cells in systemic lupus erythematosus

(2014) Kim Ohl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development

(2014) Yuquan Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis

(2014) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Sphingosine-1-Phosphate Evokes Unique Segment-Specific Vasoconstriction of the Renal Microvasculature

(2014) Z. Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

Knock Out of S1P3 Receptor Signaling Attenuates Inflammation and Fibrosis in Bleomycin-Induced Lung Injury Mice Model

(2014) Ken Murakami et al.   PLoS One

Fingolimod Increases CD39-Expressing Regulatory T Cells in Multiple Sclerosis Patients

(2014) Nathalie Muls et al.   PLoS One

Mortality and survival in systemic sclerosis: Systematic review and meta-analysis

(2014) Manuel Rubio-Rivas et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

(2014) Avram Goldberg et al.   ARTHRITIS RESEARCH & THERAPY

S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3

(2014) Saul J. Priceman et al.   Cell Reports

Predictors of cardiovascular events in patients with systemic lupus erythematosus (SLE): a systematic review and meta-analysis

(2014) Flavia Ballocca et al.   European Journal of Preventive Cardiology

Sphingosine-1–Phosphate, FTY720, and Sphingosine-1–Phosphate Receptors in the Pathobiology of Acute Lung Injury

(2013) Viswanathan Natarajan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Apolipoprotein m (APOM) levels and APOM rs805297 G/T polymorphism are associated with increased risk of rheumatoid arthritis

(2013) Yong Huang et al.   JOINT BONE SPINE

Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2

(2013) Izabela Chrobak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fingolimod Modulates Peripheral Effector and Regulatory T Cells in MS Patients

(2013) Laura D. Serpero et al.   Journal of Neuroimmune Pharmacology

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

(2013) Christopher S Garris et al.   NATURE IMMUNOLOGY

Survival and Predictors of Mortality in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: Outcomes From the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma Registry

(2013) Lorinda Chung et al.   ARTHRITIS CARE & RESEARCH

Sphingosine-1–Phosphate Receptor–3 Is a Novel Biomarker in Acute Lung Injury

(2012) Xiaoguang Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Endothelial dysfunction in rheumatic autoimmune diseases

(2012) Giuseppe Murdaca et al.   ATHEROSCLEROSIS

Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate

(2012) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Novel small-molecular therapeutics for rheumatoid arthritis

(2012) Roy Fleischmann   CURRENT OPINION IN RHEUMATOLOGY

S1P1 inhibits sprouting angiogenesis during vascular development

(2012) A. B. Shoham et al.   DEVELOPMENT

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

(2012) Konstantin Gaengel et al.   DEVELOPMENTAL CELL

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Sphingosine 1-Phosphate (S1P) Carrier-dependent Regulation of Endothelial Barrier

(2012) Brent A. Wilkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Serum Concentration of Sphingosine-1-phosphate in Juvenile-onset Systemic Lupus Erythematosus

(2012) L. Watson et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular Leak Is a Central Feature in the Pathogenesis of Systemic Sclerosis

(2012) TRACY M. FRECH et al.   JOURNAL OF RHEUMATOLOGY

Fingolimod-associated macular edema: Incidence, detection, and management

(2012) N. Jain et al.   NEUROLOGY

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia (S1P1) and Hypertension (S1P3) in Rat

(2012) Ryan M. Fryer et al.   PLoS One

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis

(2012) DeAnna A. Baker et al.   RHEUMATOLOGY INTERNATIONAL

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

(2012) Alejandra Mendoza et al.   Cell Reports

Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

(2011) Sara Elsøe et al.   ATHEROSCLEROSIS

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Common variants at the promoter region of theAPOMconfer a risk of rheumatoid arthritis

(2011) Hae-Jin Hu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

(2011) Keng G. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

(2011) Myat Lin Oo et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid phosphate phosphatase 3 enables efficient thymic egress

(2011) Béatrice Bréart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities

(2011) Y. Fujii et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

The type I interferon system in the development of lupus

(2011) Lars Rönnblom et al.   SEMINARS IN IMMUNOLOGY

Endothelial Fli1 Deficiency Impairs Vascular Homeostasis

(2010) Yoshihide Asano et al.   AMERICAN JOURNAL OF PATHOLOGY

Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury

(2010) Barry S. Shea et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity

(2010) D. H. Solomon et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic sclerosis and lupus: Points in an interferon-mediated continuum

(2010) Shervin Assassi et al.   ARTHRITIS AND RHEUMATISM

Incidence and mortality of interstitial lung disease in rheumatoid arthritis: A population-based study

(2010) Tim Bongartz et al.   ARTHRITIS AND RHEUMATISM

FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice

(2010) Seiichiro Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model

(2010) Sachi Tsunemi et al.   CLINICAL IMMUNOLOGY

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking

(2010) Maria L. Allende et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S1P1 receptor directs the release of immature B cells from bone marrow into blood

(2010) Maria L. Allende et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis

(2010) D. A. Baker et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interferon-alpha: A Therapeutic Target in Systemic Lupus Erythematosus

(2010) Mary K. Crow   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

(2010) Andrea L. Axtell et al.   Jove-Journal of Visualized Experiments

Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase

(2010) Leo R. Fitzpatrick et al.   INFLAMMOPHARMACOLOGY

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

(2009) Noriko Takuwa et al.   CARDIOVASCULAR RESEARCH

Sphingosine-1-phosphate and modulation of vascular tone

(2009) Junsuke Igarashi et al.   CARDIOVASCULAR RESEARCH

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis

(2009) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation

(2009) J. Michaud et al.   JOURNAL OF IMMUNOLOGY

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

(2009) Masaru Ishii et al.   NATURE

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

(2009) Timothy R. D. J. Radstake et al.   PLoS One

Subclinical Atherosclerosis in Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2008) Jane E. Salmon et al.   AMERICAN JOURNAL OF MEDICINE

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

(2008) Krishnan Venkataraman et al.   CIRCULATION RESEARCH

S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress

(2008) Trung H.M. Pham et al.   IMMUNITY

Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-α

(2008) Chenqi Zhao et al.   JOURNAL OF LIPID RESEARCH

Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist

(2008) Scott E. Wenderfer et al.   KIDNEY INTERNATIONAL

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

(2008) M. Mehling et al.   NEUROLOGY

The Pathology of Scleroderma Vascular Disease

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