Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

(2014) John Camm et al.   AMERICAN HEART JOURNAL

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

(2014) Kali Janes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tight junction physiology of pleural mesothelium

(2014) Alexander G. Markov et al.   Frontiers in Physiology

Tonic regulation of vascular permeability

(2013) F.-R. E. Curry et al.   Acta Physiologica

Second generation S1P pathway modulators: Research strategies and clinical developments

(2013) Marc Bigaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis

(2012) Jean Quancard et al.   CHEMISTRY & BIOLOGY

Sphingosine 1-Phosphate (S1P) Carrier-dependent Regulation of Endothelial Barrier

(2012) Brent A. Wilkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oral Sphingosine 1-Phosphate Receptor 1 (S1P1) Antagonist Prodrug with Efficacy in Vivo: Discovery, Synthesis, and Evaluation

(2012) Daniela Angst et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lymphopenia induced by a novel selective S1P1 antagonist structurally unrelated to S1P

(2011) Yasuyuki Fujii et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

(2011) Myat Lin Oo et al.   JOURNAL OF CLINICAL INVESTIGATION

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities

(2011) Y. Fujii et al.   JOURNAL OF IMMUNOLOGY

Pleural Effusions

(2011) Richard W. Light   MEDICAL CLINICS OF NORTH AMERICA

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation

(2011) T. Hla et al.   NEUROLOGY

Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury

(2010) Barry S. Shea et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY