Pioneer factors as master regulators of the epigenome and cell fate
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pioneer factors as master regulators of the epigenome and cell fate
Authors
Keywords
-
Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-03-09
DOI
10.1038/s41580-022-00464-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Enhancer grammar in development, evolution, and disease: dependencies and interplay
- (2021) Granton A. Jindal et al. DEVELOPMENTAL CELL
- FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity
- (2021) Yitzhak Reizel et al. DEVELOPMENTAL CELL
- Pioneering the developmental frontier
- (2021) Elizabeth D. Larson et al. MOLECULAR CELL
- GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo
- (2021) Marissa M Gaskill et al. eLife
- Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells
- (2021) Mário A.F. Soares et al. GENES & DEVELOPMENT
- Pax7 pioneer factor action requires both paired and homeo DNA binding domains
- (2021) Audrey Pelletier et al. NUCLEIC ACIDS RESEARCH
- High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
- (2021) Ludovica Vanzan et al. Nature Communications
- Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors
- (2020) William Hankey et al. CANCER RESEARCH
- Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated
- (2020) Markus Nevil et al. DEVELOPMENT
- DUX4 Signalling in the Pathogenesis of Facioscapulohumeral Muscular Dystrophy
- (2020) Kenji Rowel Q. Lim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- TET methylcytosine oxidases: new insights from a decade of research
- (2020) Chan-Wang J. Lio et al. JOURNAL OF BIOSCIENCES
- Mechanisms and Functions of Chromosome Compartmentalization
- (2020) Erica M. Hildebrand et al. TRENDS IN BIOCHEMICAL SCIENCES
- Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation
- (2020) Máté Pálfy et al. PLoS Genetics
- Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function
- (2020) Svetlana O. Dodonova et al. NATURE
- Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes
- (2020) Qian Yi Lee et al. NATURE CELL BIOLOGY
- Chromatin replication and epigenetic cell memory
- (2020) Kathleen R. Stewart-Morgan et al. NATURE CELL BIOLOGY
- Direct cell-fate conversion of somatic cells: Toward regenerative medicine and industries
- (2020) Kenichi HORISAWA et al. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Mechanisms of OCT4-SOX2 motif readout on nucleosomes
- (2020) Alicia K. Michael et al. SCIENCE
- HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
- (2020) Ines Desanlis et al. Nature Communications
- Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network
- (2020) Isabella V Soluri et al. eLife
- The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors
- (2020) Kenichi Horisawa et al. MOLECULAR CELL
- Odd-paired is a pioneer-like factor that coordinates with Zelda to control gene expression in embryos
- (2020) Theodora Koromila et al. eLife
- Transcription factor activity and nucleosome organization in mitosis
- (2019) Nicola Festuccia et al. GENOME RESEARCH
- H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification
- (2019) Dario Nicetto et al. SCIENCE
- Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns
- (2019) Christian Bronner et al. Genes
- Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling
- (2019) Silvia-E. Glont et al. Cell Reports
- Gene activation precedes DNA demethylation in response to infection in human dendritic cells
- (2019) Alain Pacis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA
- (2019) Unmesh Jadhav et al. MOLECULAR CELL
- Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation
- (2019) Stephen L. McDaniel et al. MOLECULAR CELL
- Pou5f3, SoxB1, and Nanog remodel chromatin on high nucleosome affinity regions at zygotic genome activation
- (2019) Marina Veil et al. GENOME RESEARCH
- Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate
- (2019) Rui Gao et al. CELL RESEARCH
- Cell Reprogramming: The Many Roads to Success
- (2019) Begüm Aydin et al. Annual Review of Cell and Developmental Biology
- Structural Features of Transcription Factors Associating with Nucleosome Binding
- (2019) Meilin Fernandez Garcia et al. MOLECULAR CELL
- FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes
- (2019) Elizabeth J. Adams et al. NATURE
- Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2
- (2019) Filippo M Cernilogar et al. NUCLEIC ACIDS RESEARCH
- FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
- (2019) Kihyun Lee et al. Cell Reports
- FOXA 2 controls the cis ‐regulatory networks of pancreatic cancer cells in a differentiation grade‐specific manner
- (2019) Marta Milan et al. EMBO JOURNAL
- Meta-analysis of Chromatin Programming by Steroid Receptors
- (2019) Ville Paakinaho et al. Cell Reports
- Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication
- (2019) Thelma M. Escobar et al. CELL
- Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening
- (2019) Alexandre Mayran et al. Nature Communications
- Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
- (2019) George E. Gentsch et al. Nature Communications
- DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression
- (2019) Rebecca Resnick et al. Cell Reports
- Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming
- (2018) Rui Li et al. GENES & DEVELOPMENT
- Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells
- (2018) John L. Johnson et al. IMMUNITY
- Pioneer transcription factors shape the epigenetic landscape
- (2018) Alexandre Mayran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming
- (2018) Ralph Stadhouders et al. NATURE GENETICS
- The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
- (2018) Jelle Jacobs et al. NATURE GENETICS
- Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate
- (2018) Alexandre Mayran et al. NATURE GENETICS
- Genetic determinants and epigenetic effects of pioneer-factor occupancy
- (2018) Julie Donaghey et al. NATURE GENETICS
- HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis
- (2018) Yuqing Sun et al. CANCER CELL
- Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
- (2018) Jose Luis Sardina et al. Cell Stem Cell
- Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)
- (2018) Jonas Ungerbäck et al. GENOME RESEARCH
- Pancreas regeneration
- (2018) Qiao Zhou et al. NATURE
- The interaction landscape between transcription factors and the nucleosome
- (2018) Fangjie Zhu et al. NATURE
- Transcription-factor-mediated supervision of global genome architecture maintains B cell identity
- (2018) Timothy M. Johanson et al. NATURE IMMUNOLOGY
- Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs
- (2018) Jeremy Dufourt et al. Nature Communications
- Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes
- (2017) Justin S. Becker et al. MOLECULAR CELL
- Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
- (2017) Adam G. Larson et al. NATURE
- Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
- (2017) Peter G Hendrickson et al. NATURE GENETICS
- Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers
- (2017) Daniel Neiman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers
- (2017) Burak H. Alver et al. Nature Communications
- Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons
- (2017) Orly L. Wapinski et al. Cell Reports
- Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective
- (2016) Erin E. Swinstead et al. BIOESSAYS
- Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions
- (2016) Erin E. Swinstead et al. CELL
- Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis
- (2016) Luis Luna-Zurita et al. CELL
- Pioneer transcription factors, chromatin dynamics, and cell fate control
- (2016) Kenneth S Zaret et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Cell fate control by pioneer transcription factors
- (2016) Makiko Iwafuchi-Doi et al. DEVELOPMENT
- Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification
- (2016) Ferdinand von Meyenn et al. DEVELOPMENTAL CELL
- A role for mitotic bookmarking of SOX2 in pluripotency and differentiation
- (2016) Cédric Deluz et al. GENES & DEVELOPMENT
- Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming
- (2016) Sören Boller et al. IMMUNITY
- Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300
- (2016) H. Jane Dyson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation
- (2016) Makiko Iwafuchi-Doi et al. MOLECULAR CELL
- Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network
- (2016) Nicola Festuccia et al. NATURE CELL BIOLOGY
- Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering
- (2016) Yu Zhang et al. NATURE GENETICS
- FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function
- (2016) Yeqing A. Yang et al. NUCLEIC ACIDS RESEARCH
- DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes
- (2016) Si Ho Choi et al. NUCLEIC ACIDS RESEARCH
- Tissue-specific DNA demethylation is required for proper B-cell differentiation and function
- (2016) Shari Orlanski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3
- (2016) Kamila M. Jozwik et al. Cell Reports
- Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming
- (2015) Abdenour Soufi et al. CELL
- NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program
- (2015) A. Pataskar et al. EMBO JOURNAL
- The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis
- (2015) Mark M Pomerantz et al. NATURE GENETICS
- Direct conversion of human fibroblasts into functional osteoblasts by defined factors
- (2015) Kenta Yamamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4
- (2015) H.- T. Hsu et al. SCIENCE
- Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis
- (2015) Alexandre A.S.F. Raposo et al. Cell Reports
- C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis
- (2015) Chris van Oevelen et al. Stem Cell Reports
- Coregulation of Transcription Factor Binding and Nucleosome Occupancy through DNA Features of Mammalian Enhancers
- (2014) Iros Barozzi et al. MOLECULAR CELL
- Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape
- (2014) Richard I Sherwood et al. NATURE BIOTECHNOLOGY
- Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
- (2013) Orly L. Wapinski et al. CELL
- Reprogramming Fibroblasts into Bipotential Hepatic Stem Cells by Defined Factors
- (2013) Bing Yu et al. Cell Stem Cell
- Induction of a Hemogenic Program in Mouse Fibroblasts
- (2013) Carlos-Filipe Pereira et al. Cell Stem Cell
- Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes
- (2013) J. M. Caravaca et al. GENES & DEVELOPMENT
- Modification of Enhancer Chromatin: What, How, and Why?
- (2013) Eliezer Calo et al. MOLECULAR CELL
- Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
- (2013) Jason D Buenrostro et al. NATURE METHODS
- DUX4 Binding to Retroelements Creates Promoters That Are Active in FSHD Muscle and Testis
- (2013) Janet M. Young et al. PLoS Genetics
- Chromatin remodeling during glucocorticoid receptor regulated transactivation
- (2012) Heather A. King et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Tissue-Specific Mitotic Bookmarking by Hematopoietic Transcription Factor GATA1
- (2012) Stephan Kadauke et al. CELL
- Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome
- (2012) Abdenour Soufi et al. CELL
- The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling
- (2012) L. Budry et al. GENES & DEVELOPMENT
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
- (2012) Christina Curtis et al. NATURE
- Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate
- (2012) R. Mansson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
- (2012) E. Lujan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism
- (2011) Ty C. Voss et al. CELL
- Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling
- (2011) Richard P. Koche et al. Cell Stem Cell
- Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons
- (2011) Samuele Marro et al. Cell Stem Cell
- Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons
- (2011) Esther Y. Son et al. Cell Stem Cell
- Array-Based Comparative Genomic Hybridization Identifies CDK4 and FOXM1 Alterations as Independent Predictors of Survival in Malignant Peripheral Nerve Sheath Tumor
- (2011) J. Yu et al. CLINICAL CANCER RESEARCH
- Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
- (2011) Biswajyoti Sahu et al. EMBO JOURNAL
- Integrative genomic profiling reveals conserved genetic mechanisms for tumorigenesis in common entities of non-Hodgkin's lymphoma
- (2011) Michael R. Green et al. GENES CHROMOSOMES & CANCER
- Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers
- (2011) A. A. Serandour et al. GENOME RESEARCH
- Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding
- (2011) Simon C. Biddie et al. MOLECULAR CELL
- A critical role for TCF-1 in T-lineage specification and differentiation
- (2011) Brittany Nicole Weber et al. NATURE
- Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
- (2011) Pengyu Huang et al. NATURE
- Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
- (2011) Sayaka Sekiya et al. NATURE
- T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
- (2011) K. Germar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct conversion of human fibroblasts to dopaminergic neurons
- (2011) U. Pfisterer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer
- (2010) L. Cao et al. CANCER RESEARCH
- Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors
- (2010) Masaki Ieda et al. CELL
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Direct conversion of human fibroblasts to multilineage blood progenitors
- (2010) Eva Szabo et al. NATURE
- Direct conversion of fibroblasts to functional neurons by defined factors
- (2010) Thomas Vierbuchen et al. NATURE
- FOXA1 is a key determinant of estrogen receptor function and endocrine response
- (2010) Antoni Hurtado et al. NATURE GENETICS
- A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
- (2010) Yin C Lin et al. NATURE IMMUNOLOGY
- Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer
- (2009) Qianben Wang et al. CELL
- Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)
- (2009) Paul G. Giresi et al. METHODS
- FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
- (2008) Mathieu Lupien et al. CELL
- PU.1 and C/EBP / convert fibroblasts into macrophage-like cells
- (2008) R. Feng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started