Journal
CELL REPORTS
Volume 29, Issue 7, Pages 1812-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.10.025
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Funding
- Friends of FSH Research [R01AR045203, P01NS069539]
- [F31NS101773]
- [T32HG000035]
- [T32HD007183]
- [T32GM007266]
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The DUX4 transcription factor is briefly expressed in the early cleavage-stage embryo, where it induces an early wave of zygotic gene transcription, whereas its mis-expression in skeletal muscle causes the muscular dystrophy facioscapulohumeral dystrophy (FSHD). Here, we show that DUX4 induces the expression of the histone variants H3.X and H3.Y. We have used a myoblast cell line with doxycycline-inducible DUX4 to show that these histone variants are incorporated throughout the body of DUX4-induced genes. Following a brief pulse of DUX4, these histones contribute to greater perdurance and to enhanced re-activation of DUX4 target gene expression. These findings provide a model for H3.X/Y as a chromatin mechanism that facilitates the expression of DUX4 target genes subsequent to a brief pulse of DUX4 expression.
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