The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering

(2021) Jeffrey Cummings et al.   Alzheimers Research & Therapy

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

(2020) Martí Colom-Cadena et al.   Alzheimers Research & Therapy

In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET

(2020) Adam P. Mecca et al.   Alzheimers & Dementia

SULT4A1 modulates synaptic development and function by promoting the formation of PSD-95/NMDAR complex

(2020) Lorenza Culotta et al.   JOURNAL OF NEUROSCIENCE

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?

(2020) Ilda D’Annessa et al.   Frontiers in Molecular Biosciences

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington’s disease

(2019) Elena Vezzoli et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena

(2019) Elena Marcello et al.   MOLECULAR NEUROBIOLOGY

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition

(2018) Max C Richter et al.   EMBO JOURNAL

The importance of data structure in statistical analysis of dendritic spine morphology

(2018) Veerle Paternoster et al.   JOURNAL OF NEUROSCIENCE METHODS

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

(2018) Joseph W. Arndt et al.   Scientific Reports

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10

(2017) Stefano Musardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer’s disease

(2017) Elena Marcello et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

(2017) Bruce G. Mockett et al.   Frontiers in Molecular Neuroscience

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

(2016) Peer-Hendrik Kuhn et al.   eLife

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion

(2015) Daniele Di Marino et al.   Journal of Chemical Theory and Computation

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

(2015) Emanuela Pasciuto et al.   NEURON

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors

(2015) Daniele Di Marino et al.   PROTEIN SCIENCE

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation

(2014) C Saraceno et al.   Cell Death & Disease

ADAM10 as a Biomarker for Alzheimer’s Disease: A Study with Brazilian Elderly

(2013) Patricia Regina Manzine et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

(2013) Elena Marcello et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

An Arginine Stretch Limits ADAM10 Exit from the Endoplasmic Reticulum

(2010) Elena Marcello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage

(2010) M. Malinverno et al.   JOURNAL OF NEUROSCIENCE

SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus

(2010) Elena Marcello et al.   NEUROBIOLOGY OF AGING

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

(2008) Tara L. Spires-Jones et al.   NEUROBIOLOGY OF DISEASE