Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders

(2022) Jeffrey M. Witkin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

(2022) Yuan Shi et al.   NATURE NEUROSCIENCE

Cellular sources of TSPO expression in healthy and diseased brain

(2021) Erik Nutma et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids

(2021) Rainer Rupprecht et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization

(2021) Tomás R. Guilarte et al.   PHARMACOLOGY & THERAPEUTICS

Impaired Cognitive Function and Hippocampal Changes Following Chronic Diazepam Treatment in Middle-Aged Mice

(2021) Tomonori Furukawa et al.   Frontiers in Aging Neuroscience

Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach

(2021) Louise Carton et al.   Translational Psychiatry

A Protective Role of Translocator Protein in Alzheimer’s Disease Brain

(2020) Marianna E. Jung   Current Alzheimer Research

Translocator protein–mediated fast-onset antidepressant-like and memory-enhancing effects in chronically stressed mice

(2020) Chao Shang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder

(2020) Sophia Attwells et al.   BIOLOGICAL PSYCHIATRY

Neuronal activity increases translocator protein (TSPO) levels

(2020) Tina Notter et al.   MOLECULAR PSYCHIATRY

Anxiolytic and Anti-depressive Like Effects of Translocator Protein (18 kDa) Ligand YL-IPA08 in a Rat Model of Postpartum Depression

(2020) Peng Ren et al.   NEUROCHEMICAL RESEARCH

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

(2020) Shivani Bhatt et al.   Nature Communications

Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts

(2020) Kerstin Kuffner et al.   Cells

In vitro and in vivo neuroprotective effects of Etifoxine in β-amyloidinduced toxicity models

(2020) Veronique Riban et al.   CNS & Neurological Disorders-Drug Targets

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

(2020) Nicole Scott‐Hewitt et al.   EMBO JOURNAL

Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons

(2020) Anna M. Barron et al.   MOLECULAR NEUROBIOLOGY

Etifoxine is non-inferior than clonazepam for reduction of anxiety symptoms in the treatment of anxiety disorders: a randomized, double blind, non-inferiority trial

(2020) Benjamín Vicente et al.   PSYCHOPHARMACOLOGY

In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease

(2020) Benjamin B. Tournier et al.   Cells

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

(2020) Alison L. Althaus et al.   NEUROPHARMACOLOGY

Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine

(2020) Lisa-Marie Bahr et al.   PSYCHONEUROENDOCRINOLOGY

Multiple functional neurosteroid binding sites on GABAA receptors

(2019) Zi-Wei Chen et al.   PLOS BIOLOGY

Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells

(2019) Stefanie Bader et al.   PSYCHONEUROENDOCRINOLOGY

VDAC1 and the TSPO: Expression, Interactions, and Associated Functions in Health and Disease States

(2019) Varda Shoshan-Barmatz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of the GABAA receptor α subunit in the mode of action of etifoxine

(2019) César Mattei et al.   PHARMACOLOGICAL RESEARCH

Microglia in Brain Development, Homeostasis, and Neurodegeneration

(2019) Christopher J. Bohlen et al.   Annual Review of Genetics

Trial of SAGE-217 in Patients with Major Depressive Disorder

(2019) Handan Gunduz-Bruce et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Systematic Review and Meta-Analysis of the Risk of Dementia Associated with Benzodiazepine Use, After Controlling for Protopathic Bias

(2018) Ross Penninkilampi et al.   CNS DRUGS

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder

(2018) Alan R. Prossin et al.   PSYCHONEUROENDOCRINOLOGY

Psychological Stress and Mitochondria

(2018) Martin Picard et al.   PSYCHOSOMATIC MEDICINE

Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression

(2018) Xu-bo Li et al.   Molecular Brain

Microglial markers in the frontal cortex are related to cognitive dysfunctions in major depressive disorder

(2018) Hua Li et al.   JOURNAL OF AFFECTIVE DISORDERS

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials

(2018) Samantha Meltzer-Brody et al.   LANCET

Translocator protein 18kDa antagonist ameliorates stress-induced stool abnormality and abdominal pain in rodent stress models

(2018) Y. Kawahara et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder

(2018) Xiao-Ying Zhang et al.   Frontiers in Pharmacology

Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry

(2017) T Notter et al.   MOLECULAR PSYCHIATRY

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

(2017) Rosa C. Paolicelli et al.   NEURON

Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder

(2017) Sophia Attwells et al.   JAMA Psychiatry

Benzodiazepine Use and Cognitive Decline in Elderly With Normal Cognition

(2016) Yuhai Zhang et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Antidepressant-Like and Anxiolytic-Like Effects of ZBD-2, a Novel Ligand for the Translocator Protein (18 kDa)

(2016) Dong-sheng Wang et al.   NEUROMOLECULAR MEDICINE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Translocator Protein (TSPO) Expression in Platelets of Depressed Patients Decreases during Antidepressant Therapy

(2016) N. Sarubin et al.   PHARMACOPSYCHIATRY

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

(2016) Shelly L Gray et al.   BMJ-British Medical Journal

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

(2016) Shelly L Gray et al.   BMJ-British Medical Journal

Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!

(2016) Siegfried Hekimi et al.   Frontiers in Genetics

Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies

(2016) Andrew Midzak et al.   Frontiers in Endocrinology

The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus

(2016) Zhi-Kun Qiu et al.   Scientific Reports

The Benzodiazepine–Dementia Disorders Link: Current State of Knowledge

(2015) Antoine Pariente et al.   CNS DRUGS

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

(2014) Jemma Gatliff et al.   Autophagy

Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder

(2014) Li-Ming Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A mitochondrial bioenergetic basis of depression

(2014) N. Jennifer Klinedinst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The Metastable Brain

(2014) Emmanuelle Tognoli et al.   NEURON

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis

(2014) Yu-Liang Miao et al.   PLoS One

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

(2014) Richard B. Banati et al.   Nature Communications

Benzodiazepine use and risk of Alzheimer's disease: case-control study

(2014) S. Billioti de Gage et al.   BMJ-British Medical Journal

A TSPO ligand is protective in a mouse model of multiple sclerosis

(2013) Daniel J. Daugherty et al.   EMBO Molecular Medicine

On the Role of the Translocator Protein (18-kDa) TSPO in Steroid Hormone Biosynthesis

(2013) Vassilios Papadopoulos   ENDOCRINOLOGY

Translocator Protein/Peripheral Benzodiazepine Receptor Is Not Required for Steroid Hormone Biosynthesis

(2013) Kanako Morohaku et al.   ENDOCRINOLOGY

Steroid hormone synthesis in mitochondria

(2013) Walter L. Miller   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The role of allopregnanolone in depression and anxiety

(2013) Cornelius Schüle et al.   PROGRESS IN NEUROBIOLOGY

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18kDa Translocator Protein (TSPO)

(2013) Alessandro Colasanti et al.   PSYCHONEUROENDOCRINOLOGY

Brief report: Depression and history of suicide attempts in adults with new-onset Type 2 Diabetes

(2013) Alyson K. Myers et al.   PSYCHONEUROENDOCRINOLOGY

Impaired mitochondrial function in psychiatric disorders

(2012) Husseini Manji et al.   NATURE REVIEWS NEUROSCIENCE

Glucocorticoids induce mitochondrial gene transcription in HepG2 cells

(2011) Anna-Maria G. Psarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS)

(2011) John Gallacher et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Selective Oestrogen Receptor Modulators Differentially Potentiate Brain Mitochondrial Function

(2011) R. W. Irwin et al.   JOURNAL OF NEUROENDOCRINOLOGY

Behavioural consequences of two chronic psychosocial stress paradigms: Anxiety without depression

(2011) David A. Slattery et al.   PSYCHONEUROENDOCRINOLOGY

Regulation of translocator protein 18kDa (TSPO) expression in health and disease states☆

(2010) Amani Batarseh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Reductions in Platelet 18-kDa Translocator Protein Density Are Associated with Adult Separation Anxiety in Patients with Bipolar Disorder

(2010) Marianna Abelli et al.   NEUROPSYCHOBIOLOGY

Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression

(2009) Barbara Costa et al.   PSYCHIATRIC GENETICS

Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

(2009) Rainer Rupprecht et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals

(2008) Antonio Armario et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS