Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids

Inflammatory and Oxidative Pathways Are New Drug Targets in Multiple Episode Schizophrenia and Leaky Gut, Klebsiella pneumoniae, and C1q Immune Complexes Are Additional Drug Targets in First Episode Schizophrenia

(2021) Michael Maes et al.   MOLECULAR NEUROBIOLOGY

C1q, a small molecule with high impact on brain development: putative role for aging processes and the occurrence of Alzheimer’s disease

(2021) Christian Rupprecht et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy

(2021) Lauren H. Fairley et al.   Journal of Neuroinflammation

Depression as a Risk Factor for Alzheimer’s Disease: A Systematic Review of Longitudinal Meta-Analyses

(2021) Olalla Sáiz-Vázquez et al.   Journal of Clinical Medicine

Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder

(2020) Sophia Attwells et al.   BIOLOGICAL PSYCHIATRY

Neuronal activity increases translocator protein (TSPO) levels

(2020) Tina Notter et al.   MOLECULAR PSYCHIATRY

Anxiolytic and Anti-depressive Like Effects of Translocator Protein (18 kDa) Ligand YL-IPA08 in a Rat Model of Postpartum Depression

(2020) Peng Ren et al.   NEUROCHEMICAL RESEARCH

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

(2020) Shivani Bhatt et al.   Nature Communications

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

(2020) Nicole Scott‐Hewitt et al.   EMBO JOURNAL

Increased serum levels of complement C1q in major depressive disorder

(2020) Qian Yao et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons

(2020) Anna M. Barron et al.   MOLECULAR NEUROBIOLOGY

Etifoxine is non-inferior than clonazepam for reduction of anxiety symptoms in the treatment of anxiety disorders: a randomized, double blind, non-inferiority trial

(2020) Benjamín Vicente et al.   PSYCHOPHARMACOLOGY

In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease

(2020) Benjamin B. Tournier et al.   Cells

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

(2020) Joon-Hyuk Lee et al.   NATURE

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

(2020) Alison L. Althaus et al.   NEUROPHARMACOLOGY

Involvement of the GABAA receptor α subunit in the mode of action of etifoxine

(2019) César Mattei et al.   PHARMACOLOGICAL RESEARCH

Trial of SAGE-217 in Patients with Major Depressive Disorder

(2019) Handan Gunduz-Bruce et al.   NEW ENGLAND JOURNAL OF MEDICINE

TSPO polymorphism in individuals with alcohol use disorder: Association with cholesterol levels and withdrawal severity

(2019) Corinde E. Wiers et al.   ADDICTION BIOLOGY

Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress

(2019) Kanako Nozaki et al.   NEUROPHARMACOLOGY

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials

(2018) Samantha Meltzer-Brody et al.   LANCET

In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence

(2017) A T Hillmer et al.   MOLECULAR PSYCHIATRY

Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia

(2017) T Notter et al.   MOLECULAR PSYCHIATRY

Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder

(2017) Sophia Attwells et al.   JAMA Psychiatry

Translocator Protein (TSPO) Expression in Platelets of Depressed Patients Decreases during Antidepressant Therapy

(2016) N. Sarubin et al.   PHARMACOPSYCHIATRY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Minireview: Translocator Protein (TSPO) and Steroidogenesis: A Reappraisal

(2015) Vimal Selvaraj et al.   MOLECULAR ENDOCRINOLOGY

Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation

(2015) Jinjiang Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

(2011) M. E. Benoit et al.   JOURNAL OF NEUROSCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Reductions in Platelet 18-kDa Translocator Protein Density Are Associated with Adult Separation Anxiety in Patients with Bipolar Disorder

(2010) Marianna Abelli et al.   NEUROPSYCHOBIOLOGY

Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

(2009) Rainer Rupprecht et al.   SCIENCE