Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

How microglia sense and regulate neuronal activity

(2020) Anthony D. Umpierre et al.   GLIA

Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling

(2019) Yong U. Liu et al.   NATURE NEUROSCIENCE

A Systematic Review and Meta-Analysis of the Risk of Dementia Associated with Benzodiazepine Use, After Controlling for Protopathic Bias

(2018) Ross Penninkilampi et al.   CNS DRUGS

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Coupling between physiological TSPO expression in brain and myocardium allows stabilization of late-phase cerebral [ 18 F]GE180 PET quantification

(2018) Maximilian Deussing et al.   NEUROIMAGE

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

(2017) Urte Neniskyte et al.   NATURE REVIEWS NEUROSCIENCE

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

(2017) Rosa C. Paolicelli et al.   NEURON

Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer’s disease

(2016) Chengyu Zou et al.   ACTA NEUROPATHOLOGICA

Benzodiazepine Use and Cognitive Decline in Elderly With Normal Cognition

(2016) Yuhai Zhang et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study

(2016) M. Brendel et al.   JOURNAL OF NUCLEAR MEDICINE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

(2016) Shelly L Gray et al.   BMJ-British Medical Journal

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

(2016) Shelly L Gray et al.   BMJ-British Medical Journal

The Benzodiazepine–Dementia Disorders Link: Current State of Knowledge

(2015) Antoine Pariente et al.   CNS DRUGS

Enhancing neurosteroid synthesis – Relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines

(2015) L Wolf et al.   PHARMACOPSYCHIATRY

Lost in translocation: the functions of the 18-kD translocator protein

(2015) Philipp Gut et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

(2015) William T. Ralvenius et al.   Nature Communications

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function

(2014) H. Hu et al.   SCIENCE

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

(2014) Richard B. Banati et al.   Nature Communications

Benzodiazepine use and risk of Alzheimer's disease: case-control study

(2014) S. Billioti de Gage et al.   BMJ-British Medical Journal

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18kDa Translocator Protein (TSPO)

(2013) Alessandro Colasanti et al.   PSYCHONEUROENDOCRINOLOGY

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

(2012) Lars Richter et al.   Nature Chemical Biology

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS)

(2011) John Gallacher et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Structural dynamics of dendritic spines in memory and cognition

(2010) Haruo Kasai et al.   TRENDS IN NEUROSCIENCES

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE