Article
Biochemistry & Molecular Biology
Stefanie Grabrucker, Jessica Pagano, Johanna Schweizer, Carolina Urrutia-Ruiz, Michael Schoen, Kevin Thome, Guenter Ehret, Andreas M. Grabrucker, Rong Zhang, Bastian Hengerer, Juergen Bockmann, Chiara Verpelli, Carlo Sala, Tobias M. Boeckers
Summary: Shank2 deficiency in mice leads to a lack of social bonding behavior towards pups, but enhancing activity in the medial preoptic area of the hypothalamus can restore social bonding behavior.
Article
Biochemistry & Molecular Biology
Jeffrey S. Burgdorf, Sehyoun Yoon, Marc Dos Santos, Catherine R. Lammert, Joseph R. Moskal, Peter Penzes
Summary: We developed a peptide fragment JB2 that promotes synaptic plasticity and has therapeutic potential for Phelan-McDermid Syndrome and Autism Spectrum Disorder (ASD).
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma C. Hays, Arianna Neal, Jaroslav Bendl, Lorna A. Farrelly, Amni Al-Kachak, Yang Lyu, Bulent Cetin, Jennifer C. Chan, Tina N. Tran, Rachael L. Neve, Randall J. Roper, Kristen J. Brennand, Panos Roussos, John C. Schimenti, Allyson K. Friedman, Li Shen, Robert D. Blitzer, Alfred J. Robison, Gerald R. Crabtree, Ian Maze
Summary: This study found that the chromatin effector BRWD1 encoded by HSA21 was upregulated in the brains of individuals with Down syndrome and trisomic mice. Selective restoration of Brwd1 gene copy numbers rescued cognitive deficits in trisomic animals. The study also showed that Brwd1 binds to the BAF chromatin remodeling complex and increased expression of Brwd1 leads to mistargeting of the BAF chromatin.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Suzanne O. Nolan, Samantha L. Hodges, Matthew S. Binder, Gregory D. Smith, James T. Okoh, Taylor S. Jefferson, Brianna Escobar, Joaquin N. Lugo
Summary: This study aimed to investigate the therapeutic efficacy of omega-3 fatty acids for the behavioral and neuroimmune phenotype of the Fmr1 knockout model. The results showed that omega-3 fatty acid supplementation reversed certain behavioral deficits but also had negative effects on other behaviors and immune functions.
Article
Endocrinology & Metabolism
Saijun Huang, Jiaying Zeng, Ruoyu Sun, Hong Yu, Haimou Zhang, Xi Su, Paul Yao
Summary: Prenatal exposure to progestin causes oxytocin suppression, leading to social deficits in mouse offspring.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Paige D. Womble, Samantha L. Hodges, Suzanne O. Nolan, Matthew S. Binder, Andrew J. Holley, Rebecca Herrera, Savannah Senger, Eliesse Kwok, David A. Narviaz, Amanda Faust, Christian J. Hernandez-Zegada, Ronald Y. Kwon, Joaquin N. Lugo
Summary: The study found that a vitamin D enriched diet can improve the behavioral phenotype of NS-Pten KO mice, including reducing activity levels and increasing sociability. Although vitamin D does not reverse bone deficits in male or female KO mice, it shows significant effects in increasing survival rate and regulating neuroinflammation markers.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Ruiqi Pang, Sumei Yan, Yunfeng Tu, Shaowen Qian, Haipeng Yu, Xianli Hu, Huizhong Wen, Wei Yuan, Xing Wang, Yi Zhou
Summary: Hearing abnormalities are important symptoms of autism spectrum disorders (ASDs). This study found that transient hearing abnormalities can be observed in Shank3B knockout mice, and these abnormalities are most prominent before the onset of social deficits. Additionally, support vector machine analysis can accurately predict the genotype of mice based on auditory brainstem response data.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Souad Nasser, Thomas Sole, Nathalie Vega, Thierry Thomas, Aneta Balcerczyk, Maura Strigini, Luciano Pirola
Summary: The ketogenic diet can alleviate symptoms of osteoarthritis by promoting weight loss, improving glycemic control, and modulating gene expression and histone post-translational modifications in the liver and kidney.
MOLECULAR METABOLISM
(2022)
Article
Neurosciences
Chunxue Liu, Yi Wang, Jingxin Deng, Jia Lin, Chunchun Hu, Qiang Li, Xiu Xu
Summary: Mutations in the SHANK3 gene are associated with some autism spectrum disorder (ASD) patients. Using a shank3-deficient zebrafish model, researchers explored the effects of VPA treatment on ASD-like behaviors and synaptic proteins expression levels, providing a potential strategy for ASD drug development.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Ludovica Pasca, Carlo Alberto Quaranta, Serena Grumi, Martina Paola Zanaboni, Anna Tagliabue, Monica Guglielmetti, Helene Vitali, Elena Capriglia, Costanza Varesio, Federico Toni, Lino Nobili, Michele Terzaghi, Valentina De Giorgis
Summary: This scoping review aimed to identify and map the effects of ketogenic dietary therapies on sleep. The findings indicate that ketogenic dietary therapies can improve overall sleep quality and sleep structure, including difficulty falling asleep, nighttime awakenings, and increased REM sleep. However, there is high variability in study design and sleep outcome evaluation among the selected studies.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Nutrition & Dietetics
Costanza Varesio, Serena Grumi, Martina Paola Zanaboni, Martina Maria Mensi, Matteo Chiappedi, Ludovica Pasca, Cinzia Ferraris, Anna Tagliabue, Renato Borgatti, Valentina De Giorgis
Summary: Research shows that ketogenic dietary therapies can significantly improve behavioral symptoms in patients with autism spectrum disorder (ASD). The implementation of KDTs has shown feasibility and potential efficacy, but dietary adherence may pose a challenge.
Article
Nutrition & Dietetics
Jacob Albers, Gearta Kraja, Danielle Eller, Karen Eck, Danielle McBrian, Jennifer M. Bain
Summary: Recent research has shown that the ketogenic diet may be beneficial for the treatment of autism spectrum disorder (ASD). However, children with ASD often have specific food behaviors, aversions to taste and texture, and increased food restrictions and allergies. This study found that adopting a ketogenic diet is feasible for children with ASD.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Neurosciences
Carly M. Drzewiecki, Amara S. Brinks, Elli P. Sellinger, Aditi D. Doshi, Jessie Y. Koh, Janice M. Juraska
Summary: BPA, an endocrine disruptor, has widespread effects on cognitive, emotional, and reproductive behaviors. Studies show that perinatal exposure to BPA increases neuron count and reduces play behavior. Furthermore, brief BPA exposure during early development leads to decreased social preference and altered expression of genes related to social deficits.
Article
Obstetrics & Gynecology
Emma G. Whatley, Thi T. Truong, Alexandra J. Harvey, David K. Gardner
Summary: Research question: Does the ketone acetoacetate (AcAc) alone, or combined with 13-hydroxybutyrate (13OHB), impact mouse embryo development, metabolism, histone acetylation and viability? The study found that exposure to high levels of ketone acetoacetate and 13-hydroxybutyrate affects metabolism and histone acetylation in embryos, and leads to abnormal fetal development.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Clinical Neurology
Nina Miljanovic, Roelof Maarten van Dijk, Verena Buchecker, Heidrun Potschka
Summary: Metabolic alterations in a Dravet mouse model were analyzed using untargeted metabolomics, showing changes in energy metabolism and impact on the glutamate/GABA-glutamine cycle. In addition, reductions in hippocampal levels of noradrenaline, corticosterone, and two bile acids were observed.