Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

Luteolin Decreases EGFR-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines

(2018) David M. Anson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Msi1 promotes tumor progression by epithelial-to-mesenchymal transition in cervical cancer

(2017) Pijun Gong et al.   HUMAN PATHOLOGY

Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells

(2017) Kyoung Ah Kang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Luteolin inhibits colorectal cancer cell epithelial-to-mesenchymal transition by suppressing CREB1 expression revealed by comparative proteomics study

(2017) Yuan Liu et al.   Journal of Proteomics

Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway

(2017) Ming-de Zang et al.   Journal of Translational Medicine

CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014

(2017) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway

(2017) Qiang Wang et al.   Oncology Letters

Overexpression of Musashi-1 protein is associated with progression and poor prognosis of gastric cancer

(2017) Zhangxuan Shou et al.   Oncology Letters

Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells

(2017) Hiroyuki Sonoki et al.   Nutrients

RNA on the brain: emerging layers of post-transcriptional regulation in cerebral cortex development

(2017) Ashley L. Lennox et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms

(2017) Yuanyuan Luo et al.   Frontiers in Pharmacology

Treatment of Glioblastoma

(2017) Joo Yeon Nam et al.   Journal of Oncology Practice

Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells

(2017) Yohan Seo et al.   PLoS One

Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit

(2016) Patricia Rosa de Araujo et al.   AMERICAN JOURNAL OF PATHOLOGY

Roles for RNA-binding proteins in development and disease

(2016) Amy E. Brinegar et al.   BRAIN RESEARCH

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer

(2016) A.G. Duffy et al.   INTERNATIONAL JOURNAL OF CANCER

Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage

(2016) Naomi L Sayre et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells

(2016) Dom-Gene Tu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism

(2016) Huanli Xu et al.   LIFE SCIENCES

Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma

(2016) Rikke D. Rasmussen et al.   Molecular Oncology

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

(2016) Rikke D. Rasmussen et al.   Nature Communications

Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo

(2015) Mrinmay Chakrabarti et al.   APOPTOSIS

Neural stem and progenitor cell fate transition requires regulation of Musashi1 function

(2015) Angus M MacNicol et al.   BMC DEVELOPMENTAL BIOLOGY

Dysregulated transcription across diverse cancer types reveals the importance of RNA-binding protein in carcinogenesis

(2015) Jing Wang et al.   BMC GENOMICS

Synergistic anti-tumor actions of luteolin and silibinin prevented cell migration and invasion and induced apoptosis in glioblastoma SNB19 cells and glioblastoma stem cells

(2015) Mrinmay Chakrabarti et al.   BRAIN RESEARCH

Olaparib: First Global Approval

(2015) Emma D. Deeks   DRUGS

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma

(2015) Philip J. Uren et al.   MOLECULAR AND CELLULAR BIOLOGY

A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness

(2015) F.M. Cambuli et al.   STEM CELLS

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins

(2015) Ning Li et al.   Cell Reports

Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation

(2015) Zhonghua Wang et al.   PLoS One

Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer

(2015) Xiao-Yang Wang et al.   Oncotarget

Prevalence of and risk factors for persistent postoperative nonanginal pain after cardiac surgery: a 2-year prospective multicentre study

(2014) M. Choiniere et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Discordant In Vitro and In Vivo Chemopotentiating Effects of the PARP Inhibitor Veliparib in Temozolomide-Sensitive versus -Resistant Glioblastoma Multiforme Xenografts

(2014) S. K. Gupta et al.   CLINICAL CANCER RESEARCH

Musashi1 regulates survival of hepatoma cell lines by activation of Wnt signalling pathway

(2014) Kunlun Chen et al.   LIVER INTERNATIONAL

Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves

(2014) In Jeon et al.   MOLECULES

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dissecting the expression landscape of RNA-binding proteins in human cancers

(2014) Bobak Kechavarzi et al.   GENOME BIOLOGY

Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity

(2013) Wen-Yu Cheng et al.   MOLECULAR BIOLOGY REPORTS

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-Binding Protein Musashi-1 Regulates Proteasome Subunit Expression in Breast Cancer- and Glioma-Initiating Cells

(2013) Chann Lagadec et al.   STEM CELLS

The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis

(2012) Dat T. Vo et al.   AMERICAN JOURNAL OF PATHOLOGY

Standards of care for treatment of recurrent glioblastoma—are we there yet?

(2012) Michael Weller et al.   NEURO-ONCOLOGY

Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions

(2011) Takako Ohyama et al.   NUCLEIC ACIDS RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival

(2010) Xiao-Yang Wang et al.   Molecular Cancer

Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy

(2008) Patricia C Sanchez-Diaz et al.   BMC CANCER

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo

(2008) Sripathi M. Sureban et al.   GASTROENTEROLOGY