De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress

(2018) Afreen Haider et al.   DEVELOPMENTAL CELL

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure

(2016) Elisabeth Corcelle-Termeau et al.   Autophagy

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

Mutations in PCYT1A, Encoding a Key Regulator of Phosphatidylcholine Metabolism, Cause Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy

(2014) Julie Hoover-Fong et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dichloroacetate and cancer: New home for an orphan drug?

(2014) Shyam Kankotia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Dichloroacetate induces autophagy in colorectal cancer cells and tumours

(2014) G Lin et al.   BRITISH JOURNAL OF CANCER

Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

(2014) Nicolas Dupont et al.   CURRENT BIOLOGY

Stearoyl-CoA Desaturase 1 Activity Is Required for Autophagosome Formation

(2014) Yuta Ogasawara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady- State 1H-MRS and Real-Time Hyperpolarized 13C-MRS Studies

(2014) Gigin Lin et al.   PLoS One

Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma

(2014) Nada M. S. Al-Saffar et al.   PLoS One

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease

(2014) F. Payne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application

(2013) L I Aronson et al.   LEUKEMIA

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae

(2011) Maki Yamagata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

De novo synthesis of phospholipids is coupled with autophagosome formation

(2011) J.P. Girardi et al.   MEDICAL HYPOTHESES

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase   Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy

(2010) N. M. S. Al-Saffar et al.   CANCER RESEARCH

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy

(2010) Wei-Lien Yen et al.   JOURNAL OF CELL BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Autophagy and tumorigenesis

(2009) Nan Chen et al.   FEBS LETTERS

Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex

(2009) Nicole Testerink et al.   JOURNAL OF LIPID RESEARCH

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Modulation of choline kinase activity in human cancer cells observed by dynamic31P NMR

(2009) Cristina Gabellieri et al.   NMR IN BIOMEDICINE

Metabolic labeling and direct imaging of choline phospholipids in vivo

(2009) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Recent progress on acyl CoA: lysophospholipid acyltransferase research

(2008) Hideo Shindou et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Glycerolipids.Phosphatidylcholine and choline homeostasis

(2008) Zhaoyu Li et al.   JOURNAL OF LIPID RESEARCH