The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression

PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways

(2021) Shuyu Mei et al.   Journal of Pathology Clinical Research

A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

(2021) Tianlu Jiang et al.   Molecular Cancer

Protein arginine methylation: from enigmatic functions to therapeutic targeting

(2021) Qin Wu et al.   NATURE REVIEWS DRUG DISCOVERY

Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer

(2021) Xinxing Wang et al.   Cell Death & Disease

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

(2021) Shasha Yin et al.   Nature Communications

PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2

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Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma

(2020) Peng Qian et al.   Cell Death & Disease

miR-331-3p Inhibits Tumor Cell Proliferation, Metastasis, Invasion by Targeting MLLT10 in Non-Small Cell Lung Cancer

(2020) Qing-Qing Tian et al.   Cancer Management and Research

Down-regulation of lncRNA UCA1 enhances radiosensitivity in prostate cancer by suppressing EIF4G1 expression via sponging miR-331-3p

(2020) Minhua Hu et al.   Cancer Cell International

Protein Arginine Methyltransferase 5 (PRMT5) Promotes Survival of Lymphoma Cells via Activation of WNT/β-CATENIN and AKT/GSK3β Proliferative Signaling

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Widespread and Functional RNA Circularization in Localized Prostate Cancer

(2019) Sujun Chen et al.   CELL

PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K/AKT in lymphoma cells

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Role of protein arginine methyltransferase 5 in human cancers

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MiR‐129‐5p promotes docetaxel resistance in prostate cancer by down‐regulating CAMK2N1 expression

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RNA-Seq reveal the circular RNAs landscape of lung cancer

(2019) Christophe Nicot   Molecular Cancer

Circular RNAs function as ceRNAs to regulate and control human cancer progression

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes

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Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway

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Circular RNAs in cancer: an emerging key player

(2017) Yeping Dong et al.   Journal of Hematology & Oncology

Circles reshaping the RNA world: from waste to treasure

(2017) Jing Liu et al.   Molecular Cancer

Arginine Methylation: The Coming of Age

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The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

(2017) Madhumitha Rengasamy et al.   NUCLEIC ACIDS RESEARCH

Circular RNAs in cancer: opportunities and challenges in the field

(2017) L S Kristensen et al.   ONCOGENE

miR-331-3p and Aurora Kinase inhibitor II co-treatment suppresses prostate cancer tumorigenesis and progression

(2017) Michael R. Epis et al.   Oncotarget

Circular RNAs: a new frontier in the study of human diseases

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A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

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Circular RNA Expression: Its Potential Regulation and Function

(2016) Julia Salzman   TRENDS IN GENETICS

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The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of miRNAs in Prostate Cancer

(2015) Tong Sun et al.   EUROPEAN UROLOGY

Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II-Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function

(2015) A. M. Prasad et al.   Journal of the American Heart Association

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling

(2015) Tao Wang et al.   Oncotarget

The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer

(2015) Tao Wang et al.   Oncotarget

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

(2014) Fengting Yan et al.   CANCER RESEARCH

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

(2014) Jakub O. Westholm et al.   Cell Reports

Circular RNAs: splicing’s enigma variations

(2013) Matthias W Hentze et al.   EMBO JOURNAL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome

(2013) Michael Girardot et al.   NUCLEIC ACIDS RESEARCH

PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

(2013) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miRNAs as biomarkers in prostate cancer

(2012) Irene Casanova-Salas et al.   Clinical & Translational Oncology

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Versatility of PRMT5-induced methylation in growth control and development

(2011) Vrajesh Karkhanis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Histone arginine methylation

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(2009) Yili Li et al.   EMBO JOURNAL

Management of Complications of Prostate Cancer Treatment

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CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes

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