Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy

(2021) Jin Yoo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

(2020) Lucía Barbier-Torres et al.   Nature Communications

Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

(2020) Yuta Ogasawara et al.   Nature Communications

Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway

(2020) Monica Nardi et al.   MOLECULES

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

(2019) Anton Iershov et al.   Nature Communications

Autophagy regulates lipid metabolism through selective turnover of NCoR1

(2019) Tetsuya Saito et al.   Nature Communications

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

(2019) Gabriela Andrejeva et al.   Autophagy

Curcumin analog CUR5–8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity

(2019) Eun Soo Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype

(2018) Huan Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

(2018) Antonella Borrelli et al.   Redox Biology

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

(2018) Norbert Stefan et al.   Lancet Diabetes & Endocrinology

Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress

(2018) Zhenxin Mou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: A review

(2018) Undurti N. Das   Journal of Advanced Research

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

(2017) Melania Gaggini et al.   HEPATOLOGY

Biochemical mechanism underlying hypertriglyceridemia and hepatic steatosis/hepatomegaly induced by acute schisandrin B treatment in mice

(2017) Yi Zhang et al.   Lipids in Health and Disease

Significant decrease of saturation index in erythrocytes membrane from subjects with non-alcoholic fatty liver disease (NAFLD)

(2017) Maria Notarnicola et al.   Lipids in Health and Disease

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

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(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging role of mammalian autophagy in ketogenesis to overcome starvation

(2016) Ayano Takagi et al.   Autophagy

Regulation of Liver Metabolism by Autophagy

(2016) Julio Madrigal-Matute et al.   GASTROENTEROLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson’s disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway

(2015) Qinghua Ba et al.   BIOMEDICINE & PHARMACOTHERAPY

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

(2015) Michaela Mueller et al.   JOURNAL OF HEPATOLOGY

Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers

(2015) Hiu Yee Kwan et al.   Scientific Reports

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

(2014) David G. Cotter et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

(2012) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

(2011) Yoshihiro Inami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advanced lipoxidation end-products

(2011) Reinald Pamplona   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells

(2011) Jian-Hong Chu   WORLD JOURNAL OF GASTROENTEROLOGY

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat

(2009) Zuoquan Xie et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

The role of fatty acids in the development and progression of nonalcoholic fatty liver disease

(2008) Christopher L. Gentile et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Schisandrin B fromSchisandra chinensisreduces hepatic lipid contents in hypercholesterolaemic mice

(2008) Si-Yuan Pan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE