Nuclear farnesoid X receptor attenuates acute kidney injury through fatty acid oxidation

The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD

(2021) Dong-Hyun Kim et al.   Cell Death & Disease

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

(2021) Kristen Renee McSweeney et al.   Cancers

Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation

(2021) Sian E. Piret et al.   KIDNEY INTERNATIONAL

Post-Translational Modifications of FXR; Implications for Cholestasis and Obesity-Related Disorders

(2021) Monique D. Appelman et al.   Frontiers in Endocrinology

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

(2020) Xiaowen Yu et al.   Science Translational Medicine

The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury

(2020) Lara Console et al.   Frontiers in Physiology

Impaired mitochondrial function of alveolar macrophages in carbon nanotube-induced chronic pulmonary granulomatous disease

(2020) Eman Soliman et al.   TOXICOLOGY

PGC1α/CEBPB/CPT1A axis promotes radiation resistance of nasopharyngeal carcinoma through activating fatty acid oxidation

(2019) Qianqian Du et al.   CANCER SCIENCE

Drug-induced acute kidney injury

(2019) Mark A. Perazella   Current Opinion in Critical Care

Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury

(2019) Hee-Seong Jang et al.   KIDNEY INTERNATIONAL

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

Molecular actions of PPARα in lipid metabolism and inflammation

(2018) Nadia Bougarne et al.   ENDOCRINE REVIEWS

Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization

(2018) Fei Zhao et al.   IMMUNITY

Bile acids in glucose metabolism in health and disease

(2018) Hagit Shapiro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress

(2018) Sujuan Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

(2018) Ekaterina Legchenko et al.   Science Translational Medicine

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival

(2018) Duncan Howie et al.   Frontiers in Immunology

Farnesoid X receptor agonist obeticholic acid inhibits renal inflammation and oxidative stress during lipopolysaccharide-induced acute kidney injury

(2018) Jin-Bo Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of the effect of acetazolamide versus mannitol on cisplatin-induced nephrotoxicity, a pilot study

(2018) Manal El Hamamsy et al.   International Journal of Clinical Pharmacy

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage

(2017) Zhibo Gai et al.   Scientific Reports

The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders

(2016) Sander M. Houten et al.   Annual Review of Physiology

The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway

(2016) Jiong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondria as therapeutic targets in acute kidney injury

(2016) Andrew M. Hall et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer

(2015) Jung-Hoon Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Effect of Silymarin Administration on Cisplatin Nephrotoxicity: Report from A Pilot, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

(2015) Foroud Shahbazi et al.   PHYTOTHERAPY RESEARCH

Effects of a DPP4 inhibitor on cisplatin-induced acute kidney injury: study protocol for a randomized controlled trial

(2015) Seon Ha Baek et al.   Trials

Tubular p53 Regulates Multiple Genes to Mediate AKI

(2014) D. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Immune cells in experimental acute kidney injury

(2014) Hye Ryoun Jang et al.   Nature Reviews Nephrology

Acute kidney injury—epidemiology, outcomes and economics

(2014) Oleksa Rewa et al.   Nature Reviews Nephrology

Farnesoid X Receptor Ligand Prevents Cisplatin-Induced Kidney Injury by Enhancing Small Heterodimer Partner

(2014) Eun Hui Bae et al.   PLoS One

Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice

(2014) Xiaoyan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

(2014) Abdullah Ozkok et al.   Biomed Research International

Pioglitazone protects against cisplatin induced nephrotoxicity in rats and potentiates its anticancer activity against human renal adenocarcinoma cell lines

(2012) Mona F. Mahmoud et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats

(2012) Zhijuan Hu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity

(2012) Jinu Kim et al.   KIDNEY INTERNATIONAL

Acute kidney injury

(2012) Rinaldo Bellomo et al.   LANCET

Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice

(2012) Annelies A. van Angelen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Sirtuin 1 in lipid metabolism and obesity

(2011) Thaddeus T. Schug et al.   ANNALS OF MEDICINE

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts

(2011) Barbara Renga et al.   INFLAMMATION RESEARCH

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES