The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD

Autophagy in kidney homeostasis and disease

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury

(2019) Chiara Poluzzi et al.   KIDNEY INTERNATIONAL

Src-mediated crosstalk between FXR and YAP protects against renal fibrosis

(2019) Dong-Hyun Kim et al.   FASEB JOURNAL

p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway

(2019) Weitang Liao et al.   FREE RADICAL RESEARCH

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis

(2018) Hong Wang et al.   EBioMedicine

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage

(2017) Zhibo Gai et al.   Scientific Reports

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Nicotine-Induced Apoptosis in Human Renal Proximal Tubular Epithelial Cells

(2016) Chang Seong Kim et al.   PLoS One

Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

(2016) Jianzhong Li et al.   Scientific Reports

Activation of FXR protects against renal fibrosis via suppressing Smad3 expression

(2016) Kai Zhao et al.   Scientific Reports

Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy

(2015) Jean-Paul Decuypere et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice

(2015) Zhibo Gai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesoid X Receptor Antagonizes JNK Signaling Pathway in Liver Carcinogenesis by ActivatingSOD3

(2015) Yan-Dong Wang et al.   MOLECULAR ENDOCRINOLOGY

Activated farnesoid X receptor attenuates apoptosis and liver injury in autoimmune hepatitis

(2015) FAN LIAN et al.   Molecular Medicine Reports

Agonist of farnesoid X receptor protects against bile acid induced damage and oxidative stress in mouse placenta – A study on maternal cholestasis model

(2015) W.-B. Wu et al.   PLACENTA

The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice

(2014) F.A.R. Lívero et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

(2014) D.-H. Kim et al.   EMBO JOURNAL

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats

(2012) Zhijuan Hu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Autophagy in proximal tubules protects against acute kidney injury

(2012) Man Jiang et al.   KIDNEY INTERNATIONAL

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy: Regulation by Energy Sensing

(2011) Alfred J. Meijer et al.   CURRENT BIOLOGY

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

(2010) Man Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Intrinsic Epithelial Cells Repair the Kidney after Injury

(2008) Benjamin D. Humphreys et al.   Cell Stem Cell

Farnesoid X Receptor Protects Liver Cells from Apoptosis Induced by Serum Deprivationin Vitroand Fastingin Vivo

(2008) Yan-Dong Wang et al.   MOLECULAR ENDOCRINOLOGY