The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?

(2014) Alex M. DePaoli et al.   DIABETES CARE

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Role of PPARγin the Differentiation and Function of Neurons

(2014) Rodrigo A. Quintanilla et al.   PPAR Research

Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation

(2013) J-H Kim et al.   CELL DEATH AND DIFFERENTIATION

The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology

(2013) Mate Kiss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Macrophages, fat, and the emergence of immunometabolism

(2013) Anthony W. Ferrante   JOURNAL OF CLINICAL INVESTIGATION

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

(2013) Nigel Turner et al.   JOURNAL OF ENDOCRINOLOGY

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

A Novel Mechanism of PPAR Gamma Induction via EGFR Signalling Constitutes Rational for Combination Therapy in Bladder Cancer

(2013) Jose Joao Mansure et al.   PLoS One

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro

(2013) Ying Liu et al.   TUMOR BIOLOGY

Stromal adipocyte PPARγ protects against breast tumorigenesis

(2012) Graham Skelhorne-Gross et al.   CARCINOGENESIS

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

The Ubiquitin Ligase Siah2 Regulates PPARγ Activity in Adipocytes

(2012) Gail Kilroy et al.   ENDOCRINOLOGY

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

(2012) Yoko Kidani et al.   IMMUNOLOGICAL REVIEWS

Pioglitazone, PPARγ Agonist, Attenuates Experimental Autoimmune Neuritis

(2012) Hhoonisha Ramkalawan et al.   INFLAMMATION

Research Resource: Diagnostic and Therapeutic Potential of Nuclear Receptor Expression in Lung Cancer

(2012) Yangsik Jeong et al.   MOLECULAR ENDOCRINOLOGY

Regulation of Chemokine and Chemokine Receptor Expression by PPARγ in Adipocytes and Macrophages

(2012) M. T. Audrey Nguyen et al.   PLoS One

Targeting PPARγSignaling Cascade for the Prevention and Treatment of Prostate Cancer

(2012) Sakshi Sikka et al.   PPAR Research

The Key to Unlocking the Chemotherapeutic Potential of PPARγLigands: Having the Right Combination

(2012) Graham Skelhorne-Gross et al.   PPAR Research

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells

(2011) Giovanni Vitale et al.   BIOTECHNOLOGY ADVANCES

Cytotoxicity of troglitazone through PPARγ-independent pathway and p38 MAPK pathway in renal cell carcinoma

(2011) Megumi Fujita et al.   CANCER LETTERS

Peroxisome proliferating activating receptor gamma–independent attenuation of interleukin 6 and interleukin 8 secretion from primary endometrial stromal cells by thiazolidinediones

(2011) Brett McKinnon et al.   FERTILITY AND STERILITY

Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells

(2011) Jung Seok Hwa et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of T cell PPAR γ in mice with experimental inflammatory bowel disease

(2010) Amir J Guri et al.   BMC GASTROENTEROLOGY

Elevated NCOR1 disrupts PPARα/γ signaling in prostate cancer and forms a targetable epigenetic lesion

(2010) Sebastiano Battaglia et al.   CARCINOGENESIS

PPARγ Agonist Suppresses TLR4 Expression and TNF-α Production in LPS Stimulated Monocyte Leukemia Cells

(2010) Chun-Zhi Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Further understanding of fat biology: Lessons from a fat fly

(2010) Joung-Woo Hong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Risk of Acute Myocardial Infarction, Stroke, Heart Failure, and Death in Elderly Medicare Patients Treated With Rosiglitazone or Pioglitazone

(2010) David J. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The small molecule phenamil is a modulator of adipocyte differentiation and PPARγ expression

(2010) Kye Won Park et al.   JOURNAL OF LIPID RESEARCH

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

(2009) Luisa Klotz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PPAR-γ AF-2 Domain Functions as a Component of a Ubiquitin-dependent Degradation Signal

(2009) Gail E. Kilroy et al.   Obesity

Posttranslational Modifications of PPAR-γ: Fine-tuning the Metabolic Master Regulator

(2009) Olivier van Beekum et al.   Obesity

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Before They Were Fat: Adipocyte Progenitors

(2008) Kye Won Park et al.   Cell Metabolism

PPAR Modulators and PPAR Pan Agonists for Metabolic Diseases: The Next Generation of Drugs Targeting Peroxisome Proliferator-Activated Receptors?

(2008) P. Feldman et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Colorectal Cancer Expression of Peroxisome Proliferator-Activated Receptor γ (PPARG, PPARgamma) Is Associated With Good Prognosis

(2008) Shuji Ogino et al.   GASTROENTEROLOGY

The many faces of PPARγ: Anti-inflammatory by any means?

(2008) Attila Szanto et al.   IMMUNOBIOLOGY

Rosiglitazone, a PPAR gamma agonist: Potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers

(2008) Ronald A. Lubet et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-γ Expression and Adipocyte Differentiation

(2008) Kye Won Park et al.   MOLECULAR ENDOCRINOLOGY

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

(2008) Natalie A. Sims et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Role for the PPARγin Cancer Therapy

(2008) Moray J. Campbell et al.   PPAR Research