The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity

Enhanced concanavalin A binding to preorganized mannose nanoarrays in glycodendrimersomes revealed multivalent interactions

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Helical Self-Organizations and Emerging Functions in Architectures, Biological and Synthetic Macromolecules

(2021) Virgil Percec et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Lipids and Lipid Derivatives for RNA Delivery

(2021) Yuebao Zhang et al.   CHEMICAL REVIEWS

Helical Chirality of Supramolecular Columns and Spheres Self‐Organizes Complex Liquid Crystals, Crystals, and Quasicrystals

(2021) Virgil Percec et al.   ISRAEL JOURNAL OF CHEMISTRY

One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA

(2021) Dapeng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

(2021) Sarah J. Shepherd et al.   NANO LETTERS

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory

(2021) Ole A. W. Haabeth et al.   ACS Central Science

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Principles for designing an optimal mRNA lipid nanoparticle vaccine

(2021) Edo Kon et al.   CURRENT OPINION IN BIOTECHNOLOGY

Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes

(2021) Shuai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers

(2021) Dapeng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Accelerated Modular-Orthogonal Ni-Catalyzed Methodology to Symmetric and Nonsymmetric Constitutional Isomeric AB2 to AB9 Dendrons Exhibiting Unprecedented Self-Organizing Principles

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An ionizable lipid toolbox for RNA delivery

(2021) Xuexiang Han et al.   Nature Communications

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

(2020) Srinivas Ramishetti et al.   ADVANCED MATERIALS

Extraordinary Acceleration of Cogwheel Helical Self-Organization of Dendronized Perylene Bisimides by the Dendron Sequence Encoding Their Tertiary Structure

(2020) Li Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers

(2020) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

(2019) Khalid A. Hajj et al.   Small

Encoding biological recognition in a bicomponent cell-membrane mimic

(2019) Cesar Rodriguez-Emmenegger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery

(2019) Nancy L. Benner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

Sequence-Defined Dendrons Dictate Supramolecular Cogwheel Assembly of Dendronized Perylene Bisimides

(2019) Benjamin E. Partridge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Beyond Chemical Synthesis: Self-Organization?!

(2018) Jean-Marie Lehn   ISRAEL JOURNAL OF CHEMISTRY

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

(2018) Yiwen Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components

(2018) Srujana S. Yadavalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

(2017) Livia Palmerston Mendes et al.   MOLECULES

Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

(2017) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

A Systematic Framework and Nanoperiodic Concept for Unifying Nanoscience: Hard/Soft Nanoelements, Superatoms, Meta-Atoms, New Emerging Properties, Periodic Property Patterns, and Predictive Mendeleev-like Nanoperiodic Tables

(2016) Donald A. Tomalia et al.   CHEMICAL REVIEWS

Onion-like glycodendrimersomes from sequence-defined Janus glycodendrimers and influence of architecture on reactivity to a lectin

(2016) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes

(2016) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From structure to function via complex supramolecular dendrimer systems

(2015) Hao-Jan Sun et al.   CHEMICAL SOCIETY REVIEWS

Glycodendrimersomes from Sequence-Defined Janus Glycodendrimers Reveal High Activity and Sensor Capacity for the Agglutination by Natural Variants of Human Lectins

(2015) Shaodong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A supramolecular helix that disregards chirality

(2015) Cécile Roche et al.   Nature Chemistry

Principles of assembly reveal a periodic table of protein complexes

(2015) S. E. Ahnert et al.   SCIENCE

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

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(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers

(2014) S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular Synthesis of Amphiphilic Janus Glycodendrimers and Their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins

(2013) Virgil Percec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

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A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Predicting the Size and Properties of Dendrimersomes from the Lamellar Structure of Their Amphiphilic Janus Dendrimers

(2011) Mihai Peterca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma

(2010) Hiroto Hatakeyama et al.   ADVANCED DRUG DELIVERY REVIEWS

Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures

(2010) V. Percec et al.   SCIENCE

The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes

(2009) Sukit Leekumjorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dendron-Mediated Self-Assembly, Disassembly, and Self-Organization of Complex Systems

(2009) Brad M. Rosen et al.   CHEMICAL REVIEWS

In quest of a systematic framework for unifying and defining nanoscience

(2009) Donald A. Tomalia   JOURNAL OF NANOPARTICLE RESEARCH

Predicting the Structure of Supramolecular Dendrimers via the Analysis of Libraries of AB3and Constitutional Isomeric AB2Biphenylpropyl Ether Self-Assembling Dendrons

(2009) Brad M. Rosen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Viral vectors: from virology to transgene expression

(2008) D Bouard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

A Periodic Table of Coiled-Coil Protein Structures

(2008) Efrosini Moutevelis et al.   JOURNAL OF MOLECULAR BIOLOGY