Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA

(2021) Dapeng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers

(2021) Dapeng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitating Endosomal Escape of a Library of Polymers for mRNA Delivery

(2020) Yuhang Jiang et al.   NANO LETTERS

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

(2020) Xucheng Hou et al.   Nature Nanotechnology

Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver

(2020) Xueliang Yu et al.   Advanced Healthcare Materials

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

(2020) Lei Miao et al.   Nature Communications

Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

(2020) Tuo Wei et al.   ACS Nano

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo

(2020) Hu Xiong et al.   JOURNAL OF CONTROLLED RELEASE

A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo

(2020) Sang Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

(2019) Asha Kumari Patel et al.   ADVANCED MATERIALS

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

Highly branched  poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells

(2019) Shuai Liu et al.   Nature Communications

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

(2019) Na Kong et al.   Science Translational Medicine

Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery

(2018) Piotr S. Kowalski et al.   ADVANCED MATERIALS

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters

(2018) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells

(2018) James C. Kaczmarek et al.   NANO LETTERS

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Combinatorial optimization of PEG architecture and hydrophobic content improves ternary siRNA polyplex stability, pharmacokinetics, and potency in vivo

(2017) Thomas A. Werfel et al.   JOURNAL OF CONTROLLED RELEASE

Bioreducible Zinc(II)-Coordinative Polyethylenimine with Low Molecular Weight for Robust Gene Delivery of Primary and Stem Cells

(2017) Shuai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

(2017) Frank Liang et al.   Science Translational Medicine

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery

(2016) Yilong Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The transition from linear to highly branched poly( -amino ester)s: Branching matters for gene delivery

(2016) D. Zhou et al.   Science Advances

Self-Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery

(2015) Hui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Highly Efficient Multifunctional Supramolecular Gene Carrier System Self-Assembled from Redox-Sensitive and Zwitterionic Polymer Blocks

(2014) Yuting Wen et al.   ADVANCED FUNCTIONAL MATERIALS

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

The development of an in vitro assay to screen lipid based nanoparticles for siRNA delivery

(2013) Ye Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA

(2013) Yan Li et al.   JOURNAL OF CONTROLLED RELEASE

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

(2013) Lei Zhang et al.   NATURE BIOTECHNOLOGY

Nanoparticles Escaping RES and Endosome: Challenges for siRNA Delivery for Cancer Therapy

(2011) Shutao Guo et al.   Journal of Nanomaterials

Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery

(2011) Jiangbing Zhou et al.   NATURE MATERIALS

Charged for success

(2011) Enrico Mastrobattista et al.   NATURE MATERIALS

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

(2011) Daniel J. Siegwart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

(2009) Shaoyi Jiang et al.   ADVANCED MATERIALS

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

(2008) Jordan J. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Zwitterionic Polymers Exhibiting High Resistance to Nonspecific Protein Adsorption from Human Serum and Plasma

(2008) Jon Ladd et al.   BIOMACROMOLECULES

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY