Thermoadaptation in an Ancestral Diterpene Cyclase by Altered Loop Stability

Exploration of binding mechanism of triclosan towards cancer markers using molecular docking and molecular dynamics

(2022) Prashant Bhardwaj et al.   CHEMOSPHERE

Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase

(2021) Karen Schriever et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parallel molecular mechanisms for enzyme temperature adaptation

(2021) Margaux M. Pinney et al.   SCIENCE

Active-site loop variations adjust activity and selectivity of the cumene dioxygenase

(2021) Peter M. Heinemann et al.   Nature Communications

Engineering Thermostability in Artificial Metalloenzymes to Increase Catalytic Activity

(2021) Megan V. Doble et al.   ACS Catalysis

Bacterial Diterpene Synthases Prenylate Small Molecules

(2021) Baofu Xu et al.   ACS Catalysis

Modular Chemoenzymatic Synthesis of Terpenes and their Analogues

(2020) Rudolf K Allemann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Designing for a green chemistry future

(2020) Julie B. Zimmerman et al.   SCIENCE

Two Diterpene Synthases from Chryseobacterium : Chryseodiene Synthase and Wanjudiene Synthase

(2020) Lukas Lauterbach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plexin-Bs enhance their GAP activity with a novel activation switch loop generating a cooperative enzyme

(2020) Zhen-lu Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selection enhances protein evolvability by increasing mutational robustness and foldability

(2020) Jia Zheng et al.   SCIENCE

Consensus sequence design as a general strategy to create hyperstable, biologically active proteins

(2019) Matt Sternke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Diterpene Biosynthesis

(2019) Jeroen S. Dickschat   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How internal cavities destabilize a protein

(2019) Mengjun Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

The state-of-the-art strategies of protein engineering for enzyme stabilization

(2018) Qian Liu et al.   BIOTECHNOLOGY ADVANCES

Ancestral diterpene cyclases show increased thermostability and substrate acceptance

(2018) Natalie M. Hendrikse et al.   FEBS Journal

Computational Design of Stable and Soluble Biocatalysts

(2018) Milos Musil et al.   ACS Catalysis

On the Temperature Dependence of Enzyme-Catalyzed Rates

(2016) Vickery L. Arcus et al.   BIOCHEMISTRY

MIB: Metal Ion-Binding Site Prediction and Docking Server

(2016) Yu-Feng Lin et al.   Journal of Chemical Information and Modeling

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

(2016) Jeffrey D. Rudolf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins

(2016) Devin L. Trudeau et al.   MOLECULAR BIOLOGY AND EVOLUTION

W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis

(2016) Jana Trifinopoulos et al.   NUCLEIC ACIDS RESEARCH

Evolutionary drivers of thermoadaptation in enzyme catalysis

(2016) Vy Nguyen et al.   SCIENCE

Dual allosteric activation mechanisms in monomeric human glucokinase

(2015) A. Carl Whittington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automatic Identification of Mobile and Rigid Substructures in Molecular Dynamics Simulations and Fractional Structural Fluctuation Analysis

(2015) Leandro Martínez   PLoS One

Terpene synthases are widely distributed in bacteria

(2014) Yuuki Yamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase

(2013) Ryan Lauchli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis

(2013) Mustafa Köksal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis

(2012) Michael J Smanski et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase fromAbies grandis

(2012) Ke Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prediction of Metal Ion–Binding Sites in Proteins Using the Fragment Transformation Method

(2012) Chih-Hao Lu et al.   PLoS One

Exploration and Mining of the Bacterial Terpenome

(2011) David E. Cane et al.   ACCOUNTS OF CHEMICAL RESEARCH

Terpene Biosynthesis: Modularity Rules

(2011) Eric Oldfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Platensimycin and platencin: promising antibiotics for future application in human medicine

(2011) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase

(2011) Mustafa Köksal et al.   Nature Chemical Biology

Relative Solvent Accessible Surface Area Predicts Protein Conformational Changes upon Binding

(2011) Joseph A. Marsh et al.   STRUCTURE

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Trinuclear metal clusters in catalysis by terpenoid synthases

(2010) Julie A. Aaron et al.   PURE AND APPLIED CHEMISTRY

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Radius of gyration as an indicator of protein structure compactness

(2008) M. Yu. Lobanov et al.   MOLECULAR BIOLOGY

An Improved General Amino Acid Replacement Matrix

(2008) S. Q. Le et al.   MOLECULAR BIOLOGY AND EVOLUTION