High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase

Chemoenzymatic preparation of germacrene analogues

(2012) Oscar Cascón et al.   CHEMICAL COMMUNICATIONS

Directed enzyme evolution: beyond the low-hanging fruit

(2012) Moshe Goldsmith et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Terpenoid synthase structures: a so far incomplete view of complex catalysis

(2012) Yang Gao et al.   NATURAL PRODUCT REPORTS

Stereoselective Friedel–Crafts alkylation catalyzed by squalene hopene cyclases

(2012) Stephan C. Hammer et al.   TETRAHEDRON

Activation-Independent Cyclization of Monoterpenoids

(2011) Gabriele Siedenburg et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhancing the Thermal Robustness of an Enzyme by Directed Evolution: Least Favorable Starting Points and Inferior Mutants Can Map Superior Evolutionary Pathways

(2011) Yosephine Gumulya et al.   CHEMBIOCHEM

Genome Mining in Streptomyces clavuligerus: Expression and Biochemical Characterization of Two New Cryptic Sesquiterpene Synthases

(2011) Yunfeng Hu et al.   CHEMISTRY & BIOLOGY

Strategy and success for the directed evolution of enzymes

(2011) Paul A Dalby   CURRENT OPINION IN STRUCTURAL BIOLOGY

Computational design and selections for an engineered, thermostable terpene synthase

(2011) Juan E. Diaz et al.   PROTEIN SCIENCE

A Multiproduct Terpene Synthase fromMedicago truncatulaGenerates Cadalane Sesquiterpenes via Two Different Mechanisms

(2010) Stefan Garms et al.   JOURNAL OF ORGANIC CHEMISTRY

Genome Mining inStreptomyces avermitilis: Cloning and Characterization of SAV_76, the Synthase for a New Sesquiterpene, Avermitilol

(2010) Wayne K. W. Chou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural sesquiterpenoids

(2010) Braulio M. Fraga   NATURAL PRODUCT REPORTS

Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control

(2010) E. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Diversity of sesquiterpene synthases in the basidiomyceteCoprinus cinereus

(2009) Sean Agger et al.   MOLECULAR MICROBIOLOGY

Exploring protein fitness landscapes by directed evolution

(2009) Philip A. Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase

(2009) David J. Miller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Sesquiterpene Synthase from the Botrydial Biosynthetic Gene Cluster of the PhytopathogenBotrytis cinerea

(2008) Cristina Pinedo et al.   ACS Chemical Biology

Unearthing the roots of the terpenome

(2008) David W Christianson   CURRENT OPINION IN CHEMICAL BIOLOGY

Photometric assay of methanol and formaldehyde in industrial waste-waters using alcohol oxidase and 3-methyl-2-benzothiazolinone hydrazone

(2008) Vladimir A. Sibirny et al.   INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY

Identification of Sesquiterpene Synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. Strain PCC 7120

(2008) S. A. Agger et al.   JOURNAL OF BACTERIOLOGY

Ab initio analysis of the Cope rearrangement of germacrane sesquiterpenoids

(2008) William N. Setzer   JOURNAL OF MOLECULAR MODELING

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

(2008) Paul E O'Maille et al.   Nature Chemical Biology

Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: Probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233–Mg2+B motif

(2007) L. Sangeetha Vedula et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS