Bacterial Diterpene Synthases Prenylate Small Molecules

Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid

(2021) Chenxi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase

(2020) Jonathan R. Chekan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene–Nucleoside

(2020) Dorothy A. Okoth et al.   MOLECULES

Functional characterization of a new terpene synthase from Plectranthus amboinicus

(2020) Nur Suhanawati Ashaari et al.   PLoS One

Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases

(2020) Haibing He et al.   Nature Communications

Hoodwinking Cytochrome P450BM3 into Hydroxylating Non-Native Substrates by Exploiting Its Substrate Misrecognition

(2019) Osami Shoji et al.   ACCOUNTS OF CHEMICAL RESEARCH

Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

(2019) Ronja Driller et al.   Beilstein Journal of Organic Chemistry

Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering

(2019) Eric J N Helfrich et al.   Beilstein Journal of Organic Chemistry

Identification and characterization of terpene synthase genes accounting for volatile terpene emissions in flowers of Freesia x hybrida

(2018) Fengzhan Gao et al.   JOURNAL OF EXPERIMENTAL BOTANY

Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis

(2018) Yanlong Yang et al.   JOURNAL OF NATURAL PRODUCTS

Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli

(2018) Kevin W. George et al.   METABOLIC ENGINEERING

Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis

(2018) Liujuan Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis

(2018) Ronja Driller et al.   Nature Communications

Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery

(2018) Tingting Yao et al.   Nature Communications

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5

(2016) Lilan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan-containing cyclic dipeptides

(2016) Aili Fan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biosynthesis of fungal meroterpenoids

(2016) Yudai Matsuda et al.   NATURAL PRODUCT REPORTS

Bacterial terpene cyclases

(2016) Jeroen S. Dickschat   NATURAL PRODUCT REPORTS

Bringing Bioactive Compounds into Membranes: The UbiA Superfamily of Intramembrane Aromatic Prenyltransferases

(2016) Weikai Li   TRENDS IN BIOCHEMICAL SCIENCES

Prenyltransferases as key enzymes in primary and secondary metabolism

(2015) Julia Winkelblech et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks

(2015) John A. Gerlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

(2015) Gordon M. Cragg et al.   MEDICAL PRINCIPLES AND PRACTICE

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds

(2015) Franziska Leipoldt et al.   PLoS One

Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c

(2014) E. Layre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production

(2013) Jorge Alonso-Gutierrez et al.   METABOLIC ENGINEERING

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes

(2012) Feifei Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

(2012) Zhongli Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and Characterization of Xiamycin A and Oxiamycin Gene Cluster Reveals an Oxidative Cyclization Strategy Tailoring Indolosesquiterpene Biosynthesis

(2012) Huixian Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Based Engineering Increased the Catalytic Turnover Rate of a Novel Phenazine Prenyltransferase

(2012) Georg Zocher et al.   PLoS One

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis

(2011) M. J. Smanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Edaxadiene: A New Bioactive Diterpene fromMycobacterium tuberculosis

(2010) Francis M. Mann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trinuclear metal clusters in catalysis by terpenoid synthases

(2010) Julie A. Aaron et al.   PURE AND APPLIED CHEMISTRY

Complete Characterization of the Seventeen Step Moenomycin Biosynthetic Pathway

(2009) Bohdan Ostash et al.   BIOCHEMISTRY

Cloning and Heterologous Expression of the Cyclooctatin Biosynthetic Gene Cluster Afford a Diterpene Cyclase and Two P450 Hydroxylases

(2009) Seung-Young Kim et al.   CHEMISTRY & BIOLOGY

Prenyl transfer to aromatic substrates in the biosynthesis of aminocoumarins, meroterpenoids and phenazines: The ABBA prenyltransferase family

(2009) Orwah Saleh et al.   PHYTOCHEMISTRY

Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities

(2008) Takuto Kumano et al.   BIOORGANIC & MEDICINAL CHEMISTRY