Znc2 module of RAG1 contributes towards structure-specific nuclease activity of RAGs

Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor

(2020) Namrata M. Nilavar et al.   Cell Death Discovery

Cracking the DNA Code for V(D)J Recombination

(2018) Min-Sung Kim et al.   MOLECULAR CELL

Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures

(2017) Karla K. Rodgers   TRENDS IN BIOCHEMICAL SCIENCES

HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination

(2017) Mayilaadumveettil Nishana et al.   Cell Death & Disease

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Biochemical Characterization of Nonamer Binding Domain of RAG1 Reveals its Thymine Preference with Respect to Length and Position

(2016) Deepthi Raveendran et al.   Scientific Reports

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

Structure-specific nuclease activity of RAGs is modulated by sequence, length and phase position of flanking double-stranded DNA

(2014) Rupa Kumari et al.   FEBS Journal

A non-B DNA can replace heptamer of V(D)J recombination when present along with a nonamer: implications in chromosomal translocations and cancer

(2012) Mayilaadumveettil Nishana et al.   BIOCHEMICAL JOURNAL

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Role of non-homologous end joining in V(D)J recombination

(2012) Shruti Malu et al.   IMMUNOLOGIC RESEARCH

Mechanism of Fragility atBCL2Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation

(2012) Mridula Nambiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-Dependent Predominance of Nonhomologous DNA End-Joining Pathways during Embryonic Development in Mice

(2012) Kishore K. Chiruvella et al.   JOURNAL OF MOLECULAR BIOLOGY

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Differential Reaction Kinetics, Cleavage Complex Formation, and Nonamer Binding Domain Dependence Dictate the Structure-Specific and Sequence-Specific Nuclease Activity of RAGs

(2011) Abani Kanta Naik et al.   JOURNAL OF MOLECULAR BIOLOGY

Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures

(2010) Abani Kanta Naik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma

(2010) Mridula Nambiar et al.   NUCLEIC ACIDS RESEARCH

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

(2009) Fang Fang Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY