Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo

Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

(2021) Kunimaro Furuta et al.   JOURNAL OF CLINICAL INVESTIGATION

Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis

(2021) Mengfei Liu et al.   Nature Communications

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

(2019) Moira B. Hilscher et al.   GASTROENTEROLOGY

Targeting a moonlighting function of aldolase induces apoptosis in cancer cells

(2019) Agnieszka Gizak et al.   Cell Death & Disease

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

(2018) Changwei Dou et al.   GASTROENTEROLOGY

FGF-dependent metabolic control of vascular development

(2017) Pengchun Yu et al.   NATURE

Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis

(2017) Longwei Liu et al.   NATURE MATERIALS

Angiocrine signaling in the hepatic sinusoids in health and disease

(2016) Enis Kostallari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanosensitive components of integrin adhesions: Role of vinculin

(2016) Paul Atherton et al.   EXPERIMENTAL CELL RESEARCH

Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension

(2016) Ester Garcia-Pras et al.   GUT

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

(2016) Arupratan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights

(2016) Thomas Greuter et al.   JOURNAL OF GASTROENTEROLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis

(2015) Sabine Klein et al.   GUT

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces

(2015) Douglas A. Simonetto et al.   HEPATOLOGY

What are super-enhancers?

(2015) Sebastian Pott et al.   NATURE GENETICS

Integrin α4β1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration

(2015) Xiaohong Zhang et al.   NUCLEIC ACIDS RESEARCH

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

Mechanotransduction and fibrosis

(2014) Dominik Duscher et al.   JOURNAL OF BIOMECHANICS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tissue mechanics and fibrosis

(2013) Rebecca G. Wells   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Integrins in mechanotransduction

(2013) Tyler D Ross et al.   CURRENT OPINION IN CELL BIOLOGY

Activation of NF-κB by fluid shear stress, but not TNF-α, requires focal adhesion kinase in osteoblasts

(2010) Suzanne R.L. Young et al.   BONE

Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response

(2009) Li Tang et al.   GASTROENTEROLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines

(2008) Arnhild Schrage et al.   HEPATOLOGY