Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

(2020) Peng Zhao et al.   SCIENCE

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

(2020) Jason S. Seidman et al.   IMMUNITY

Role of liver sinusoidal endothelial cells in nonalcoholic fatty liver disease

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

(2019) Moira B. Hilscher et al.   GASTROENTEROLOGY

Assay validation and clinical performance of chronic inflammatory and chemokine biomarkers of NASH fibrosis

(2019) Sumit Kar et al.   PLoS One

Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH

(2019) Qianqian Guo et al.   JOURNAL OF HEPATOLOGY

A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis

(2019) Hintermann et al.   Cells

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

(2018) Samar H Ibrahim et al.   GUT

Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

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Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells

(2018) Zhongwei Liu et al.   International Heart Journal

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease

(2017) S Lefere et al.   INTERNATIONAL JOURNAL OF OBESITY

New insights to the mechanisms underlying atherosclerosis in rheumatoid arthritis

(2017) Mahdi Mahmoudi et al.   International Journal of Rheumatic Diseases

Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity

(2017) Kyoko Tomita et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance

(2017) Yasutaka Miyachi et al.   Cell Reports

Dynamic plasticity of macrophage functions in diseased liver

(2017) Thomas Ritz et al.   CELLULAR IMMUNOLOGY

Epidemiology and natural history of non-alcoholic fatty liver disease

(2016) Yousef Fazel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline

(2016) Hao Chen et al.   PLoS Computational Biology

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

(2015) Samar H. Ibrahim et al.   HEPATOLOGY

Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

(2015) Masashi Miyao et al.   LABORATORY INVESTIGATION

Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis

(2015) Michael T. Wong et al.   Cell Reports

HiChIP: a high-throughput pipeline for integrative analysis of ChIP-Seq data

(2014) Huihuang Yan et al.   BMC BIOINFORMATICS

TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells

(2014) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

High-dimensional analysis of the murine myeloid cell system

(2014) Burkhard Becher et al.   NATURE IMMUNOLOGY

Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies

(2014) Perle Totoson et al.   ARTHRITIS RESEARCH & THERAPY

An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis

(2013) Masahiko Matsumoto et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival

(2013) Cyrill Géraud et al.   LIVER INTERNATIONAL

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis

(2013) Samar H. Ibrahim et al.   LIVER INTERNATIONAL

Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice

(2012) Jong-Gil Park et al.   ATHEROSCLEROSIS

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

(2011) Michael Charlton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Recent and Emerging Therapeutic Medications in Type 2 Diabetes Mellitus

(2010) Margaret C. Lo et al.   AMERICAN JOURNAL OF THERAPEUTICS

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial

(2008) Jean-Claude Tardif et al.   LANCET

Of lineage and legacy: the development of mammalian hematopoietic stem cells

(2008) Elaine Dzierzak et al.   NATURE IMMUNOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY