A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant

A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy

(2014) Hiroko Miyabe et al.   JOURNAL OF CONTROLLED RELEASE

Neutralized Nanoparticle Composed of SS-Cleavable and pH-Activated Lipid-Like Material as a Long-Lasting and Liver-Specific Gene Delivery System

(2014) Masami Ukawa et al.   Advanced Healthcare Materials

A DNA microarray-based analysis of immune-stimulatory and transcriptional responses of dendritic cells to KALA-modified nanoparticles

(2013) Hidetaka Akita et al.   BIOMATERIALS

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

(2013) Elizabeth Helgason et al.   FEBS LETTERS

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Action of Adjuvants

(2013) Sunita Awate et al.   Frontiers in Immunology

A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine: Concept and Applications

(2012) T. Nakamura et al.   ACCOUNTS OF CHEMICAL RESEARCH

The emerging role of DNA methylation in epileptogenesis

(2012) Katja Kobow et al.   EPILEPSIA

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

The future of human DNA vaccines

(2012) Lei Li et al.   JOURNAL OF BIOTECHNOLOGY

Proteomic and Functional Analyses of Protein–DNA Complexes During Gene Transfer

(2012) Melissa A Badding et al.   MOLECULAR THERAPY

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine

(2011) Sharif M. Shaheen et al.   BIOMATERIALS

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

(2011) Glen N Barber   CURRENT OPINION IN IMMUNOLOGY

Regulation of effector and memory T-cell functions by type I interferon

(2011) Jonathan P. Huber et al.   IMMUNOLOGY

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

(2011) Nicole Frahm et al.   JOURNAL OF CLINICAL INVESTIGATION

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy

(2010) Yu-Zhe Chen et al.   Clinical & Developmental Immunology

Minimal doses of a sequence-optimized transgene mediate high-level and long-term EPO expression in vivo: challenging CpG-free gene design

(2010) D Kosovac et al.   GENE THERAPY

DNA vaccines: an historical perspective and view to the future

(2010) Margaret A. Liu   IMMUNOLOGICAL REVIEWS

The effect of CpG motifs on gene expression and clearance kinetics of aerosol administered polyethylenimine (PEI)–plasmid DNA complexes in the lung

(2010) Eugenia Lesina et al.   JOURNAL OF CONTROLLED RELEASE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The impact of intragenic CpG content on gene expression

(2010) Asli Petra Bauer et al.   NUCLEIC ACIDS RESEARCH

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process

(2009) Hidetaka Akita et al.   BIOMATERIALS

Clinical trial design for adenoviral gene therapy products

(2009) T. Shirakawa   DRUG NEWS & PERSPECTIVES

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression

(2009) Masaru Mitsui et al.   JOURNAL OF GENE MEDICINE

Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes

(2009) K. Yasuda et al.   JOURNAL OF IMMUNOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

(2008) Olivier Joffre et al.   IMMUNOLOGICAL REVIEWS

Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes

(2008) Takashi Nakamura et al.   MOLECULAR THERAPY

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression

(2008) Stephen C Hyde et al.   NATURE BIOTECHNOLOGY

Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system

(2007) Kentaro Kogure et al.   ADVANCED DRUG DELIVERY REVIEWS