Journal
ACS COMBINATORIAL SCIENCE
Volume 18, Issue 2, Pages 87-99Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.5b00108
Keywords
structural DNA nanotechnology; RNA nanotechnology; materials science; bioengineering
Funding
- Global Innovative Research Center (GiRC) Program through National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2012K1A1A2A01056093]
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2013R1A2A2A04015829]
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2015R1A1A1A05001174]
- National Research Foundation of Korea [2013R1A2A2A04015829] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The self-assembly feature of the naturally occurring biopolymer, DNA, has fascinated researchers in the fields of materials science and bioengineering. With the improved understanding of the chemical and structural nature of DNA, DNA based constructs have been designed and fabricated from two-dimensional arbitrary shapes to reconfigurable three-dimensional nanodevices. Although DNA has been used successfully as a building block in a finely organized and controlled manner, its applications need to be explored. Hence, with the myriad of biological functions, RNA has recently attracted considerable attention to further the application of nucleic acid-based structures. This Review categorizes different approaches of engineering nucleic acid-based structures and introduces the concepts, principles, and applications of each technique, focusing on how DNA engineering is applied as a guide to RNA engineering.
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