Influence of the Microbiota-Gut-Brain Axis on Cognition in Alzheimer’s Disease

The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota

(2021) Friedrich Leblhuber et al.   Nutrients

The Microbiome and Alzheimer’s Disease: Potential and Limitations of Prebiotic, Synbiotic, and Probiotic Formulations

(2021) Karan Arora et al.   Frontiers in Bioengineering and Biotechnology

The Effect of Multiprobiotics on Memory and Attention in Fibromyalgia: A Pilot Randomized Controlled Trial

(2021) Diana Cardona et al.   International Journal of Environmental Research and Public Health

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

(2021) Alessio Vittorio Colombo et al.   eLife

Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review

(2021) Qiming Tan et al.   Autism Research

Risk Factors for Alzheimer’s Disease: An Epidemiological Study

(2021) Jana Janoutová et al.   Current Alzheimer Research

Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles

(2021) Diana Younan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nutrition, Gut Microbiota, and Alzheimer's Disease

(2021) Mariana Romanenko et al.   Frontiers in Psychiatry

Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer’s Disease Transgenic Mouse Model at an Early Disease Stage

(2020) W.M.A.D. Binosha Fernando et al.   JOURNAL OF ALZHEIMERS DISEASE

Sequence variant analysis reveals poor correlations in microbial taxonomic abundance between humans and mice after gnotobiotic transfer

(2020) Farnaz Fouladi et al.   ISME Journal

Serum triglycerides in Alzheimer disease

(2020) Megan M. Bernath et al.   NEUROLOGY

Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review

(2020) Arthi Chinna Meyyappan et al.   BMC Psychiatry

Effects of Probiotic Supplementation on Short Chain Fatty Acids in the AppNL-G-F Mouse Model of Alzheimer’s Disease

(2020) Harpreet Kaur et al.   JOURNAL OF ALZHEIMERS DISEASE

Rapid improvement in Alzheimer’s disease symptoms following fecal microbiota transplantation: a case report

(2020) Sabine Hazan   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Microbial involvement in Alzheimer disease development and progression

(2020) Hannah R. Bulgart et al.   Molecular Neurodegeneration

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

(2020) Charlotte Mezö et al.   Acta Neuropathologica Communications

Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics

(2020) John Chulhoon Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Effects of APOE e4‐allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients ( AgeCoDe )

(2020) Francisca S. Rodriguez et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

(2020) Moira Marizzoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Minocycline differentially modulates human spatial memory systems

(2020) Sam C. Berens et al.   NEUROPSYCHOPHARMACOLOGY

A specific dietary fibre supplementation improves cognitive performance—an exploratory randomised, placebo-controlled, crossover study

(2020) Kirsten Berding et al.   PSYCHOPHARMACOLOGY

Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder—Preliminary Results of the PROVIT Study

(2020) Alexandra Reiter et al.   Nutrients

Human gut microbiota Agathobaculum butyriciproducens improves cognitive impairment in LPS-induced and APP/PS1 mouse models of Alzheimer's disease

(2020) Jun Go et al.   NUTRITION RESEARCH

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2019) Yun-Ha Hwang et al.   Nutrients

MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study

(2019) Diane E. Hosking et al.   Alzheimers & Dementia

Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort

(2019) Ping Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology

(2019) Tam T. T. Tran et al.   FASEB JOURNAL

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

(2019) Hemraj B. Dodiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The kynurenine pathway: a finger in every pie

(2019) Jonathan Savitz   MOLECULAR PSYCHIATRY

Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

(2019) John P. Haran et al.   mBio

Fecal metabolite of a gnotobiotic mouse transplanted with gut microbiota from a patient with Alzheimer’s disease

(2019) Yusuke Fujii et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota

(2019) Dae-Wook Kang et al.   Scientific Reports

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

(2019) Binyin Li et al.   Alzheimers & Dementia

Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice

(2019) Feng Zhu et al.   MOLECULAR PSYCHIATRY

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

(2019) Ravinder Nagpal et al.   EBioMedicine

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

(2018) Meng-Fei Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Benefaction of probiotics for human health: A review

(2018) Rout George Kerry et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

A controversy on the role of short-chain fatty acids in the pathogenesis of Parkinson's disease

(2018) Agata Mulak   MOVEMENT DISORDERS

Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies

(2018) Francesca Pistollato et al.   PHARMACOLOGICAL RESEARCH

The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron

(2018) Amy N. Jacobson et al.   mBio

Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study

(2018) Lee-Ching Lew et al.   CLINICAL NUTRITION

Probiotic Supplementation in Patients with Alzheimer’s Dementia – An Explorative Intervention Study

(2018) Friedrich Leblhuber et al.   Current Alzheimer Research

Sodium Butyrate Improves Memory Function in an Alzheimer's Disease Mouse Model When Administered at an Advanced Stage of Disease Progression

(2018) Nambirajan Govindarajan et al.   JOURNAL OF ALZHEIMERS DISEASE

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbiota influence the development of the brain and behaviors in C57BL/6J mice

(2018) Jing Lu et al.   PLoS One

The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies

(2017) Paula Perez-Pardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

(2017) Ling Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

(2017) Carolin Brandscheid et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammatory responses in Alzheimer’s disease

(2017) Cira Dansokho et al.   JOURNAL OF NEURAL TRANSMISSION

Fos Protein as a Marker of Neuronal Activity: a Useful Tool in the Study of the Mechanism of Action of Natural Products with Analgesic Activity

(2017) Priscila L. Santos et al.   MOLECULAR NEUROBIOLOGY

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

The role of microbial amyloid in neurodegeneration

(2017) Robert P. Friedland et al.   PLoS Pathogens

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE–/– mice brains

(2017) Sim K. Singhrao et al.   Journal of Oral Microbiology

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

(2017) Laura Bonfili et al.   Scientific Reports

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease

(2017) Myles R. Minter et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Human Microbiota-Associated Mice: A Model with Challenges

(2016) Marie-Claire Arrieta et al.   Cell Host & Microbe

Current Understanding of Dysbiosis in Disease in Human and Animal Models

(2016) Arianna K. DeGruttola et al.   INFLAMMATORY BOWEL DISEASES

Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans

(2016) Li Zhang et al.   ISME Journal

Alzheimer’s Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention

(2016) Herbert B. Allen   JOURNAL OF ALZHEIMERS DISEASE

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

(2016) Elmira Akbari et al.   Frontiers in Aging Neuroscience

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

MIND diet slows cognitive decline with aging

(2015) Martha Clare Morris et al.   Alzheimers & Dementia

Brain morphology links systemic inflammation to cognitive function in midlife adults

(2015) Anna L. Marsland et al.   BRAIN BEHAVIOR AND IMMUNITY

Maintaining and Monitoring the Defined Microbiota Status of Gnotobiotic Rodents

(2015) Werner Nicklas et al.   ILAR JOURNAL

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease

(2015) Judith Miklossy   Frontiers in Aging Neuroscience

Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene

(2015) Y. B. Wei et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

The Diagnosis and Management of Mild Cognitive Impairment

(2014) Kenneth M. Langa et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Fecal Microbiota Transplantation for the Treatment of Clostridium difficile Infection

(2014) Giovanni Cammarota et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Mild Cognitive Impairment: Diagnosis, Longitudinal Course, and Emerging Treatments

(2014) Jennifer N. Vega et al.   Current Psychiatry Reports

The genetics of Alzheimer's disease

(2014) Eva Bagyinszky et al.   Clinical Interventions in Aging

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis

(2013) S. Davari et al.   NEUROSCIENCE

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

(2008) Lieve Desbonnet et al.   JOURNAL OF PSYCHIATRIC RESEARCH