Article
Clinical Neurology
Tommy Kwan Hin Fong, Teris Cheung, Sze Ting Joanna Ngan, Kelvin Tong, Wai Yan Vivian Lui, Wai Chi Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng
Summary: This study aimed to assess the effectiveness and tolerability of transcranial pulse stimulation (TPS) with neuro-navigation in older adults with mild neurocognitive disorder (NCD). The results showed a significant improvement in cognition of elderly with mild NCD after receiving TPS intervention. This study provides valuable information for the long-term effect of TPS in cognition in older adults.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Sara Bernini, Silvia Panzarasa, Elena Sinforiani, Silvana Quaglini, Stefano F. Cappa, Chiara Cerami, Cristina Tassorelli, Tomaso Vecchi, Sara Bottiroli
Summary: This study aims to compare the effects of computer-based interventions on participants with neurocognitive disorders in two different modalities: at the hospital and at home. Conducting a non-inferiority trial to verify the comparability of HomeCoRe with CoRe, and to provide further support for the use of HomeCoRe in distance treatment.
FRONTIERS IN NEUROLOGY
(2021)
Review
Geriatrics & Gerontology
Felix Bermejo-Pareja, Israel Contador, Teodoro del Ser, Javier Olazaran, Sara Llamas-Velasco, Saturio Vega, Julian Benito-Leon
Summary: MCI is the most commonly mentioned predementia entity, recognized as a harbinger of dementia caused by various etiologies, mainly MCI due to Alzheimer's disease. The operational definition of MCI has shortcomings, as does the recent miNCD construct. Current data suggest that miNCD is a stricter predementia condition with lower prevalence than MCI, less sensitivity to cognitive decline, and possibly a higher conversion rate to dementia.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Marcia Maria Amendola-Pires, Max K. Fakoury, Hellen Salazar, Silvia B. De Oliveira, Carlos Eduardo Brandao-Mello, Sergio L. Schmidt
Summary: Hepatitis C virus (HCV) infection can lead to liver cirrhosis, hepatocellular carcinoma, and liver-related deaths. This study found that asymptomatic HCV subjects showed deficits in reaction time (RT) and intraindividual variability of reaction time (VRT) compared to healthy controls.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Zahinoor Ismail, Alexander McGirr, Sascha Gill, Sophie Hu, Nils D. Forkert, Eric E. Smith
Summary: The study showed that individuals with both MBI and SCD had the highest risk of cognitive and functional decline, suggesting that these two conditions combined can serve as a simple and scalable method to identify high-risk patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Sara Isernia, Monia Cabinio, Sonia Di Tella, Stefania Pazzi, Federica Vannetti, Filippo Gerli, Irene Eleonora Mosca, Gemma Lombardi, Claudio Macchi, Sandro Sorbi, Francesca Baglio
Summary: The study confirmed the validity of SASG in detecting MCI and VCI from healthy controls, with high diagnostic sensitivity and specificity. SASG effectively captured the cognitive profiles of MCI and VCI, showing good classification accuracy.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Binyin Li, Huidong Tang, Guiying He, Zhijia Jin, Yixi He, Pei Huang, Naying He, Shengdi Chen
Summary: Cognitive training combined with Tai Chi has positive effects on delaying mild cognitive impairment (MCI) progression to dementia. Prolonged mixed training further delays decline in global cognition and memory. Functional magnetic resonance imaging shows increased regional activity in both cognitive training and Tai Chi group.
ALZHEIMERS & DEMENTIA
(2023)
Article
Health Care Sciences & Services
Ran Li, Jiawei Geng, Runze Yang, Yumeng Ge, Therese Hesketh
Summary: This systematic review suggests that computerized cognitive training (CCT) interventions could improve global cognitive function in patients with mild cognitive impairment (MCI), although the evidence is still limited. More comprehensive trials are needed to evaluate the impact of CCT on cognitive decline, especially in the longer term, and to determine whether CCT should be recommended for use in clinical practice.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Y. Lu, X. Gwee, D. Q. Chua, T. S. Lee, W. S. Lim, M. S. Chong, P. Yap, K. B. Yap, I. Rawtaer, T. M. Liew, F. Pan, Tze Pin Ng
Summary: Research suggests that older adults at high nutritional risk are more likely to develop cognitive decline and neurocognitive disorders, including MCI or dementia. Identifying vulnerable subpopulations for correction of malnutrition risk may help prevent neurocognitive disorders.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Psychology, Multidisciplinary
Sara Bernini, Elena Ballante, Federico Fassio, Silvia Panzarasa, Silvana Quaglini, Chiara Riccietti, Alfredo Costa, Stefano F. Cappa, Cristina Tassorelli, Tomaso Vecchi, Sara Bottiroli
Summary: The study aimed to identify factors influencing preference for either cognitive telerehabilitation (TR) or in-person cognitive training (CT) programs in older adults with risk of dementia or early cognitive impairment. The results suggest that socio-demographic characteristics and lifestyle habits play a significant role in influencing treatment preferences.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Ling Yue, Dan Hu, Han Zhang, Junhao Wen, Ye Wu, Wei Li, Lin Sun, Xia Li, Jinghua Wang, Guanjun Li, Tao Wang, Dinggang Shen, Shifu Xiao
Summary: By using neuroimaging and machine learning models, the progression from SCD to MCI in high-risk individuals can be predicted, with identified factors influencing the progression. This study provides important insights for future neuropathological research on AD.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Sheina Emrani, Melissa Lamar, Catherine Price, Satya Baliga, Victor Wasserman, Emily F. Matusz, Johnathan Saunders, Vaughn Gietka, James Strate, Rod Swenson, Ganesh Baliga, David J. Libon
Summary: This study operationally defined constructs underlying executive attention theory using intra-component latencies from a backward digit test in patients with suspected mild cognitive impairment (MCI). Different time allocation patterns were found in MCI patients, indicating potential utility for identifying neurodegenerative diseases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Anna E. Bruus, Gunhild Waldemar, Asmus Vogel
Summary: Autobiographical memory may be impaired in the early stages of Alzheimer's disease, even when standardized tests show no decline, suggesting that subjective cognitive decline may be an indicator of early AD-related memory deficits.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Jennifer N. Vega, Lilia Zurkovsky, Kimberly Albert, Alyssa Melo, Brian Boyd, Julie Dumas, Neil Woodward, Brenna C. McDonald, Andrew J. Saykin, Joon H. Park, Magdalena Naylor, Paul A. Newhouse
FRONTIERS IN NEUROSCIENCE
(2016)
Article
Geriatrics & Gerontology
Shashwath A. Meda, Mary Ellen I. Koran, Jennifer R. Pryweller, Jennifer N. Vega, Tricia A. Thornton-Wells
NEUROBIOLOGY OF AGING
(2013)
Article
Geriatrics & Gerontology
Jennifer N. Vega, Julie Dumas, Paul A. Newhouse
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2017)
Article
Neurosciences
Jennifer N. Vega, Timothy J. Hohman, Jennifer R. Pryweller, Elisabeth M. Dykens, Tricia A. Thornton-Wells
BRAIN CONNECTIVITY
(2015)
Article
Clinical Neurology
Mary Ellen I. Koran, Timothy J. Hohman, Courtney M. Edwards, Jennifer N. Vega, Jennifer R. Pryweller, Laura E. Slosky, Genea Crockett, Lynette Villa de Rey, Shashwath A. Meda, Nathan Dankner, Suzanne N. Avery, Jennifer U. Blackford, Elisabeth M. Dykens, Tricia A. Thornton-Wells
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2014)