The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging

Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms?

(2021) Rebecca Piccarducci et al.   Oxidative Medicine and Cellular Longevity

Circulating miR‐19a‐3p and miR‐19b‐3p characterize the human aging process and their isomiRs associate with healthy status at extreme ages

(2021) Cristina Morsiani et al.   AGING CELL

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

(2021) Isabelle Schiffer et al.   eLife

The MicroRNA Family Gets Wider: The IsomiRs Classification and Role

(2021) Luisa Tomasello et al.   Frontiers in Cell and Developmental Biology

Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue

(2021) Ping Li et al.   Frontiers in Cell and Developmental Biology

The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness

(2020) Kou-Juey Wu   Biomedical Journal

miRNA degradation in the mammalian brain

(2020) Chun K. Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of miR-486-5p and myostatin

(2020) Yun-Ching Chang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

microRNA strand selection: Unwinding the rules

(2020) Jeffrey C. Medley et al.   Wiley Interdisciplinary Reviews-RNA

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR‐127 in aged animals

(2020) Sanna Loppi et al.   AGING CELL

Common diseases alter the physiological age-related blood microRNA profile

(2020) Tobias Fehlmann et al.   Nature Communications

Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs

(2020) Angelica Giuliani et al.   Scientific Reports

LncRNA UCA1 sponges miR-206 to exacerbate oxidative stress and apoptosis induced by ox-LDL in human macrophages

(2019) Xiaorong Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

5p and 3p Strands of miR-34 Family Members Have Differential Effects in Cell Proliferation, Migration, and Invasion in Cervical Cancer Cells

(2019) Sergio Córdova-Rivas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IsomiRs: Expanding the miRNA repression toolbox beyond the seed

(2019) Xavier Bofill-De Ros et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

MicroRNAs as modulators of longevity and the aging process

(2019) Holly E. Kinser et al.   HUMAN GENETICS

MiR‐34b‐3p represses cell proliferation, cell cycle progression and cell apoptosis in non‐small‐cell lung cancer (NSCLC) by targeting CDK4

(2019) Hongxiang Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structural Basis for Target-Directed MicroRNA Degradation

(2019) Jessica Sheu-Gruttadauria et al.   MOLECULAR CELL

Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

(2019) Camilla Nehammer et al.   eLife

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity

(2018) Esteban Luna et al.   ACTA NEUROPATHOLOGICA

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Cell-type specific sequencing of microRNAs from complex animal tissues

(2018) Chiara Alberti et al.   NATURE METHODS

MicroRNA degradation by a conserved target RNA regulates animal behavior

(2018) Angelo Bitetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ER Proteostasis Control of Neuronal Physiology and Synaptic Function

(2018) Gabriela Martínez et al.   TRENDS IN NEUROSCIENCES

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

MicroRNA degradation by a conserved target RNA regulates animal behavior

(2018) Angelo Bitetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging

(2018) Antti P. Aalto et al.   PLoS Genetics

Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

(2018) Francesco Ghini et al.   Nature Communications

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

(2018) Karolina Pircs et al.   Cell Reports

microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle

(2018) Yan Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Accumulation of Ribosome-Associated Isolated 3′ UTRs in Neuronal Cell Populations of the Aging Brain

(2018) Peter H. Sudmant et al.   Cell Reports

Myocardin inhibited the gap protein connexin 43 via promoted miR-206 to regulate vascular smooth muscle cell phenotypic switch

(2017) Hui Li et al.   GENE

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging

(2017) Fabiola Olivieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians

(2017) C. Borrás et al.   MECHANISMS OF AGEING AND DEVELOPMENT

MicroRNAs and the metabolic hallmarks of aging

(2017) Berta Victoria et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates

(2017) Baekgyu Kim et al.   MOLECULAR CELL

Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types

(2017) Aristeidis G. Telonis et al.   NUCLEIC ACIDS RESEARCH

A microRNA feedback loop regulates global microRNA abundance during aging

(2017) Sachi Inukai et al.   RNA

Dicer and microRNAs protect adult dopamine neurons

(2017) Piotr Chmielarz et al.   Cell Death & Disease

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

(2016) Felipe G. et al.   Aging-US

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

(2016) Kai Kaarniranta et al.   CELL BIOLOGY AND TOXICOLOGY

Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice

(2016) Bin Liu et al.   DIABETES

Dysregulation of miRNA isoform level at 5ʹ end in Alzheimer's disease

(2016) Shengqin Wang et al.   GENE

Degradation dynamics of microRNAs revealed by a novel pulse-chase approach

(2016) Matteo J. Marzi et al.   GENOME RESEARCH

Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic ProfilesNovelty and Significance

(2016) Srinivas Ayyadevara et al.   HYPERTENSION

Altered Proteins in the Aging Brain

(2016) Adila Elobeid et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The World report on ageing and health: a policy framework for healthy ageing

(2016) John R Beard et al.   LANCET

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Distribution of miRNA expression across human tissues

(2016) Nicole Ludwig et al.   NUCLEIC ACIDS RESEARCH

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Role of Carbonyl Modifications on Aging-Associated Protein Aggregation

(2016) Maya Tanase et al.   Scientific Reports

The role of microRNAs in skeletal muscle health and disease

(2015) John J. McCarthy   Frontiers in Bioscience-Landmark

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Stress Induces p38 MAPK-Mediated Phosphorylation and Inhibition of Drosha-Dependent Cell Survival

(2015) Qian Yang et al.   MOLECULAR CELL

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

(2014) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Variety of Dicer Substrates in Human and C. elegans

(2014) Agnieszka Rybak-Wolf et al.   CELL

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of MicroRNAs Linked to Regulators of Muscle Protein Synthesis and Regeneration in Young and Old Skeletal Muscle

(2014) Evelyn Zacharewicz et al.   PLoS One

Drosha as an interferon-independent antiviral factor

(2014) J. S. Shapiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

A non-canonical landscape of the microRNA system

(2014) Gabriel A. Cipolla   Frontiers in Genetics

New directions in ER stress-induced cell death

(2013) Susan E. Logue et al.   APOPTOSIS

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscle-specific MicroRNA1 (miR1) Targets Heat Shock Protein 70 (HSP70) during Dexamethasone-mediated Atrophy

(2013) Himani Kukreti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand

(2013) Ashley M. Fenn et al.   NEUROBIOLOGY OF AGING

Ageing and the small, non-coding RNA world

(2012) Masaomi Kato et al.   AGEING RESEARCH REVIEWS

Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

(2012) Marcelo A. Mori et al.   Cell Metabolism

MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response

(2012) Andrew E. Byrd et al.   JOURNAL OF CELL BIOLOGY

The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders

(2012) Koichi Wakabayashi et al.   MOLECULAR NEUROBIOLOGY

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

(2012) Nan Liu et al.   NATURE

Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs

(2012) Philip Knuckles et al.   NATURE NEUROSCIENCE

Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain

(2012) Sachi Inukai et al.   PLoS One

Evidence for a cytoplasmic microprocessor of pri-miRNAs

(2012) J. S. Shapiro et al.   RNA

IsomiRs – the overlooked repertoire in the dynamic microRNAome

(2012) Corine T. Neilsen et al.   TRENDS IN GENETICS

Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis

(2012) S Gupta et al.   Cell Death & Disease

MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9

(2011) Jurong Yang et al.   AGE

Age-related changes in the function of autophagy in rat kidneys

(2011) Jing Cui et al.   AGE

Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy

(2011) Michael J. Eddins et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

microRNA-34c is a novel target to treat dementias

(2011) Athanasios Zovoilis et al.   EMBO JOURNAL

Translational Suppression of Atrophic Regulators by MicroRNA-23a Integrates Resistance to Skeletal Muscle Atrophy

(2011) Shogo Wada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

microRNA and aging: A novel modulator in regulating the aging network

(2010) Li-Hsin Chen et al.   AGEING RESEARCH REVIEWS

MicroRNAs Both Promote and Antagonize Longevity in C. elegans

(2010) Alexandre de Lencastre et al.   CURRENT BIOLOGY

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

(2009) I. Lee et al.   GENOME RESEARCH

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES