Structural Bases of Prion Variation in Yeast

Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system

(2022) Yoshiko Nakagawa et al.   Nature Chemical Biology

Differential Interactions of Molecular Chaperones and Yeast Prions

(2022) Yury A. Barbitoff et al.   Journal of Fungi

The hunt for ancient prions: Archaeal prion-like domains form amyloid-based epigenetic elements

(2021) Tomasz Zajkowski et al.   MOLECULAR BIOLOGY AND EVOLUTION

Dangerous Stops: Nonsense Mutations Can Dramatically Increase Frequency of Prion Conversion

(2021) Alexander A. Dergalev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Innate immunity to prions: anti-prion systems turn a tsunami of prions into a slow drip

(2021) Reed B. Wickner et al.   CURRENT GENETICS

High-resolution structure and strain comparison of infectious mammalian prions

(2021) Allison Kraus et al.   MOLECULAR CELL

α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?

(2021) Simon Oliver Hoppe et al.   Biomolecules

The non‐prion SUP35 preexists in large chaperone‐containing molecular complexes

(2021) Shiwha Park et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate

(2021) Suzanne Lam et al.   Acta Neuropathologica Communications

Bottom-up synthesis of protein-based nanomaterials from engineered β-solenoid proteins

(2020) Zeyu Peng et al.   PLoS One

Out-of-register parallel β-sheets and antiparallel β-sheets coexist in 150 kDa oligomers formed by Amyloid-β(1-42)

(2020) Yuan Gao et al.   JOURNAL OF MOLECULAR BIOLOGY

The actin cytoskeletal network plays a role in yeast prion transmission and contributes to prion stability

(2020) Jane E. Dorweiler et al.   MOLECULAR MICROBIOLOGY

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

(2020) Ruben Hervas et al.   SCIENCE

The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease

(2020) Heather H. C. Lau et al.   ACTA NEUROPATHOLOGICA

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies

(2020) Myungjin Jo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Normal levels of ribosome-associated chaperones cure two groups of [PSI+] prion variants

(2020) Moonil Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutable yeast prion variants are stabilized by a defective Hsp104 chaperone

(2020) Yu‐Wen Huang et al.   MOLECULAR MICROBIOLOGY

Structural and molecular basis of cross-seeding barriers in amyloids

(2020) Asen Daskalov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A viral expression factor behaves as a prion

(2019) Hao Nan et al.   Nature Communications

RNA Sequencing Reveals Specific Transcriptomic Signatures Distinguishing Effects of the [SWI+] Prion and SWI1 Deletion in Yeast Saccharomyces cerevisiae

(2019) Yury V. Malovichko et al.   Genes

Prion Variants of Yeast are Numerous, Mutable, and Segregate on Growth, Affecting Prion Pathogenesis, Transmission Barriers, and Sensitivity to Anti-Prion Systems

(2019) Reed Wickner et al.   Viruses-Basel

Anti-prion systems in yeast

(2019) Reed B. Wickner   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast Sup35 Prion Structure: Two Types, Four Parts, Many Variants

(2019) Alexander Dergalev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Amyloid Polymorphism on Prion-Chaperone Interactions in Yeast

(2019) Andrea N. Killian et al.   Viruses-Basel

Functional Amyloids

(2019) Daniel Otzen et al.   Cold Spring Harbor Perspectives in Biology

A complete catalog of wild-type Sup35 prion variants and their protein-only propagation

(2019) Yu-Wen Huang et al.   CURRENT GENETICS

Toward Understanding the Silk Fiber Structure: 13C Solid-State NMR Studies of the Packing Structures of Alanine Oligomers before and after Trifluoroacetic Acid Treatment

(2019) Tetsuo Asakura et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Anti-Prion Systems in Yeast and Inositol Polyphosphates

(2018) Reed B. Wickner et al.   BIOCHEMISTRY

Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance

(2018) Yvonne Duernberger et al.   MOLECULAR AND CELLULAR BIOLOGY

Nonsense-mediated mRNA decay factors cure most [PSI+] prion variants

(2018) Moonil Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for diversification of yeast prion strain conformation

(2018) Yumiko Ohhashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Insoluble Protein Deposit (IPOD) in Yeast

(2018) Stephanie Rothe et al.   Frontiers in Molecular Neuroscience

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

The Pub1 and Upf1 Proteins Act in Concert to Protect Yeast from Toxicity of the [PSI+] Prion

(2018) Valery Urakov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

(2018) Silvia A. Purro et al.   NATURE

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

(2017) Abhisek Mukherjee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1

(2017) Kacy R. Paul et al.   MOLECULAR AND CELLULAR BIOLOGY

[PSI+] prion propagation is controlled by inositol polyphosphates

(2017) Reed B. Wickner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp104 disaggregase at normal levels cures many [PSI+] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p

(2017) Anton Gorkovskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress

(2017) Tatiana A. Chernova et al.   Cell Reports

The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy

(2017) Patrick H. W. Chan et al.   Scientific Reports

A glutamine/asparagine-rich fragment of Gln3, but not the full-length protein, aggregates in Saccharomyces cerevisiae

(2016) K. S. Antonets et al.   BIOCHEMISTRY-MOSCOW

Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits

(2016) Sohini Chakrabortee et al.   CELL

Polyglutamine Fibrils: New Insights into Antiparallel β-Sheet Conformational Preference and Side Chain Structure

(2016) David Punihaole et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets

(2016) Angela B. Soriaga et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Luminidependens (LD) is an Arabidopsis protein with prion behavior

(2016) Sohini Chakrabortee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biology and Genetics of PrP Prion Strains

(2016) Sina Ghaemmaghami   Cold Spring Harbor Perspectives in Medicine

Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae

(2016) Anton A. Nizhnikov et al.   PLoS Genetics

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

(2016) Ester Vázquez-Fernández et al.   PLoS Pathogens

Engineering Amyloid Fibrils from β-Solenoid Proteins for Biomaterials Applications

(2015) Maria D.R. Peralta et al.   ACS Nano

Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus

(2015) Kendra K. Frederick et al.   CELL

Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator

(2015) Mohammed Repon Khan et al.   CELL

Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics

(2014) Kendra K. Frederick et al.   CHEMISTRY & BIOLOGY

Locating folds of the in-register parallel  -sheet of the Sup35p prion domain infectious amyloid

(2014) A. Gorkovskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-associated activity contributes to the severity and toxicity of a prion phenotype

(2014) John A. Pezza et al.   Nature Communications

Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic Regions

(2014) Kevin C. Stein et al.   PLoS Genetics

Contribution of Specific Residues of the β-Solenoid Fold to HET-s Prion Function, Amyloid Structure and Stability

(2014) Asen Daskalov et al.   PLoS Pathogens

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Exploring the Basis of [PIN+] Variant Differences in [PSI+] Induction

(2013) Jaya Sharma et al.   JOURNAL OF MOLECULAR BIOLOGY

Spontaneous Variants of the [RNQ+] Prion in Yeast Demonstrate the Extensive Conformational Diversity Possible with Prion Proteins

(2013) Vincent J. Huang et al.   PLoS One

The Effects of Amino Acid Composition of Glutamine-Rich Domains on Amyloid Formation and Fragmentation

(2012) Alexander I. Alexandrov et al.   PLoS One

Prion formation by a yeast GLFG nucleoporin

(2012) Randal Halfmann et al.   Prion

A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress

(2012) G. Suzuki et al.   SCIENCE

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

A Small, Glutamine-Free Domain Propagates the [SWI+] Prion in Budding Yeast

(2011) E. T. Crow et al.   MOLECULAR AND CELLULAR BIOLOGY

Suicidal [PSI+] is a lethal yeast prion

(2011) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

In Sup35p filaments (the [PSI+] prion), the globular C-terminal domains are widely offset from the amyloid fibril backbone

(2010) Ulrich Baxa et al.   MOLECULAR MICROBIOLOGY

Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover

(2010) T. Mastushita-Sakai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

A heritable switch in carbon source utilization driven by an unusual yeast prion

(2009) J. C.S. Brown et al.   GENES & DEVELOPMENT

The Functional Curli Amyloid Is Not Based on In-register Parallel β-Sheet Structure

(2009) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural diversity of the soluble trimers of the human amylin(20–29) peptide revealed by molecular dynamics simulations

(2009) Yuxiang Mo et al.   JOURNAL OF CHEMICAL PHYSICS

Heterologous Prion Interactions Are Altered by Mutations in the Prion Protein Rnq1p

(2009) J. Patrick Bardill et al.   JOURNAL OF MOLECULAR BIOLOGY

The paradox of viable sup45 STOP mutations: a necessary equilibrium between translational readthrough, activity and stability of the protein

(2009) Denis Kiktev et al.   MOLECULAR GENETICS AND GENOMICS

Sequestration of essential proteins causes prion associated toxicity in yeast

(2009) Namitha Vishveshwara et al.   MOLECULAR MICROBIOLOGY

The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

(2009) Basant K. Patel et al.   NATURE CELL BIOLOGY

Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

(2009) Y. Nekooki-Machida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloids of Shuffled Prion Domains That Form Prions Have a Parallel In-Register β-Sheet Structure†

(2008) Frank Shewmaker et al.   BIOCHEMISTRY

Curing of the [URE3] prion by Btn2p, a Batten disease-related protein

(2008) Dmitry S Kryndushkin et al.   EMBO JOURNAL

Variant-specific [PSI+] Infection Is Transmitted by Sup35 Polymers within [PSI+] Aggregates with Heterogeneous Protein Composition

(2008) Sviatoslav N. Bagriantsev et al.   MOLECULAR BIOLOGY OF THE CELL

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

(2008) Zhiqiang Du et al.   NATURE GENETICS

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register  -sheet structure

(2008) R. B. Wickner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain-specific sequences required for yeast [PSI+] prion propagation

(2008) H.-Y. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE