Impact of Amyloid Polymorphism on Prion-Chaperone Interactions in Yeast

Anti-prion systems in yeast

(2019) Reed B. Wickner   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 at the membrane: driving protein translocation

(2018) Elizabeth A. Craig   BMC BIOLOGY

Variant-specific and reciprocal Hsp40 functions in Hsp104-mediated prion elimination

(2018) Michael T. Astor et al.   MOLECULAR MICROBIOLOGY

Curing of [PSI+] by Hsp104 Overexpression: Clues to solving the puzzle

(2018) Lois E. Greene et al.   Prion

Chaperone functional specificity promotes yeast prion diversity

(2018) Andrea N. Killian et al.   PLoS Pathogens

Function, evolution, and structure of J-domain proteins

(2018) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Forms and Abundance of Chaperone Proteins Influence Yeast Prion Variant Competition

(2018) Chang-I Yu et al.   MOLECULAR MICROBIOLOGY

Heat shock protein 104 (Hsp104)-mediated curing of [PSI+] yeast prions depends on both [PSI+] conformation and the properties of the Hsp104 homologs

(2017) Xiaohong Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1

(2017) Yury A. Barbitoff et al.   MOLECULAR MICROBIOLOGY

Prion-specific Hsp40 function: The role of the auxilin homolog Swa2

(2017) Emily E. Oliver et al.   Prion

Hsp104 disaggregase at normal levels cures many [PSI+] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p

(2017) Anton Gorkovskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Evolutionary Conservation and Emerging Functional Diversity of the Cytosolic Hsp70:J Protein Chaperone Network of Arabidopsis thaliana

(2017) Amit K. Verma et al.   G3-Genes Genomes Genetics

Broadening the functionality of a J-protein/Hsp70 molecular chaperone system

(2017) Brenda A. Schilke et al.   PLoS Genetics

Human J-protein DnaJB6b Cures a Subset ofSaccharomyces cerevisiaePrions and Selectively Blocks Assembly of Structurally Related Amyloids

(2015) Michael Reidy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast Prions: Structure, Biology, and Prion-Handling Systems

(2015) Reed B. Wickner et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Swa2, the yeast homolog of mammalian auxilin, is specifically required for the propagation of the prion variant [URE3-1]

(2015) Elizabeth M. Troisi et al.   MOLECULAR MICROBIOLOGY

Feedback control of prion formation and propagation by the ribosome-associated chaperone complex

(2015) Denis A. Kiktev et al.   MOLECULAR MICROBIOLOGY

Hsp40 function in yeast prion propagation: Amyloid diversity necessitates chaperone functional complexity

(2015) Zachary A Sporn et al.   Prion

The ribosome-associated complex antagonizes prion formation in yeast

(2015) Alvaro J Amor et al.   Prion

Hsp90-Associated Immunophilin Homolog Cpr7 Is Required for the Mitotic Stability of [URE3] Prion in Saccharomyces cerevisiae

(2015) Navinder Kumar et al.   PLoS Genetics

Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics

(2014) Kendra K. Frederick et al.   CHEMISTRY & BIOLOGY

Myopathy-causing Mutations in an HSP40 Chaperone Disrupt Processing of Specific Client Conformers

(2014) Kevin C. Stein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural variants of yeast prions show conformer-specific requirements for chaperone activity

(2014) Kevin C. Stein et al.   MOLECULAR MICROBIOLOGY

Regulation of the Hsp104 Middle Domain Activity Is Critical for Yeast Prion Propagation

(2014) Jennifer E. Dulle et al.   PLoS One

Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants

(2014) Reed B. Wickner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Diversification of Hsp40: Distinct J-Protein Functional Requirements for Two Prions Allow for Chaperone-Dependent Prion Selection

(2014) Julia M. Harris et al.   PLoS Genetics

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines

(2014) Michael Reidy et al.   PLoS Genetics

Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic Regions

(2014) Kevin C. Stein et al.   PLoS Genetics

Prion Strains and Amyloid Polymorphism Influence Phenotypic Variation

(2014) Kevin C. Stein et al.   PLoS Pathogens

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

Sequential Duplications of an Ancient Member of the DnaJ-Family Expanded the Functional Chaperone Network in the Eukaryotic Cytosol

(2013) Chandan Sahi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Spontaneous Variants of the [RNQ+] Prion in Yeast Demonstrate the Extensive Conformational Diversity Possible with Prion Proteins

(2013) Vincent J. Huang et al.   PLoS One

Low activity of select Hsp104 mutants is sufficient to propagate unstable prion variants

(2013) Jennifer E Dulle et al.   Prion

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

Chaperone Proteins Select and Maintain [PIN+] Prion Conformations inSaccharomyces cerevisiae

(2012) David L. Lancaster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Influence of prion variant and yeast strain variation on prion-molecular chaperone requirements

(2012) Justin K. Hines et al.   Prion

Molecular pathogenesis of sporadic prion diseases in man

(2012) Jiri G. Safar   Prion

Molecular Chaperone Hsp104 Can Promote Yeast Prion Generation

(2011) Dmitry S. Kryndushkin et al.   GENETICS

Functions of Yeast Hsp40 Chaperone Sis1p Dispensable for Prion Propagation but Important for Prion Curing and Protection From Prion Toxicity

(2011) P. Aaron Kirkland et al.   GENETICS

Destabilization and Recovery of a Yeast Prion after Mild Heat Shock

(2011) Gary P. Newnam et al.   JOURNAL OF MOLECULAR BIOLOGY

The sensitive [SWI+] prion

(2011) Justin K. Hines et al.   Prion

Suicidal [PSI+] is a lethal yeast prion

(2011) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion diseases of yeast: Amyloid structure and biology

(2011) Reed B. Wickner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Correction: [SWI+], the Prion Formed by the Chromatin Remodeling Factor Swi1, Is Highly Sensitive to Alterations in Hsp70 Chaperone System Activity

(2011) Justin K. Hines et al.   PLoS Genetics

The M-Domain Controls Hsp104 Protein Remodeling Activity in an Hsp70/Hsp40-Dependent Manner

(2010) Bernhard Sielaff et al.   JOURNAL OF MOLECULAR BIOLOGY

Sti1 Regulation of Hsp70 and Hsp90 Is Critical for Curing of Saccharomyces cerevisiae [PSI+] Prions by Hsp104

(2010) M. Reidy et al.   MOLECULAR AND CELLULAR BIOLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Influence of Hsp70s and their regulators on yeast prion propagation

(2010) Daniel C. Masison et al.   Prion

Structure and function of the molecular chaperone Hsp104 from yeast

(2009) Valerie Grimminger-Marquardt et al.   BIOPOLYMERS

Prion Variants and Species Barriers Among Saccharomyces Ure2 Proteins

(2009) H. K. Edskes et al.   GENETICS

Ssa1 Overexpression and [PIN+] Variants Cure [PSI+] by Dilution of Aggregates

(2009) Vidhu Mathur et al.   JOURNAL OF MOLECULAR BIOLOGY

Design and construction of diverse mammalian prion strains

(2009) D. W. Colby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp70/Hsp90 co-chaperones are required for efficient Hsp104-mediated elimination of the yeast [PSI+] prion but not for prion propagation

(2009) Behrooz Moosavi et al.   YEAST

Curing of the [URE3] prion by Btn2p, a Batten disease-related protein

(2008) Dmitry S Kryndushkin et al.   EMBO JOURNAL

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

(2008) T. Higurashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA