Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells

Connexin 43: A Target for the Treatment of Inflammation in Secondary Complications of the Kidney and Eye in Diabetes

(2022) Chelsy L. Cliff et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low-Energy Shock Wave Plus Intravesical Instillation of Botulinum Toxin A for Interstitial Cystitis/Bladder Pain Syndrome: Pathophysiology and Preliminary Result of a Novel Minimally Invasive Treatment

(2022) Yuan-Hong Jiang et al.   Biomedicines

The Role of Connexin Hemichannels in Inflammatory Diseases

(2022) Bo Peng et al.   Biology-Basel

Comparing surgical interventions for interstitial cystitis: A systematic review

(2022) Diego Agustín Abelleyra Lastoria et al.   LUTS-Lower Urinary Tract Symptoms

Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders

(2021) Kentaro Matsuzaki et al.   Nutrients

Urothelium-Specific Deletion of Connexin43 in the Mouse Urinary Bladder Alters Distension-Induced ATP Release and Voiding Behavior

(2021) Jin Kono et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy and safety of intravesical instillation of KRP‐116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double‐blind, placebo‐controlled, clinical study

(2021) Naoki Yoshimura et al.   INTERNATIONAL JOURNAL OF UROLOGY

Efficacy and safety comparison of pharmacotherapies for interstitial cystitis and bladder pain syndrome: a systematic review and Bayesian network meta-analysis

(2021) Xing-peng Di et al.   INTERNATIONAL UROGYNECOLOGY JOURNAL

Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome

(2021) Hung-Jen Shih et al.   BIOMEDICINE & PHARMACOTHERAPY

IL-6/STAT3 pathway is involved in the regulation of autophagy in chronic non-bacterial prostatitis cells, and may be affected by the NLRP3 inflammasome

(2021) Lidong Chen et al.   ULTRASTRUCTURAL PATHOLOGY

Beneficial effects of a nobiletin‐rich formulated supplement of Sikwasa ( C. depressa ) peel on cognitive function in elderly Japanese subjects; A multicenter, randomized, double‐blind, placebo‐controlled study

(2021) Shizuo Yamada et al.   Food Science & Nutrition

Clinical guidelines for interstitial cystitis/bladder pain syndrome

(2020) Yukio Homma et al.   INTERNATIONAL JOURNAL OF UROLOGY

Phenolic composition, antioxidant potential and health benefits of citrus peel

(2020) Balwinder Singh et al.   FOOD RESEARCH INTERNATIONAL

Antioxidant Nobiletin Enhances Oocyte Maturation and Subsequent Embryo Development and Quality

(2020) Yulia N. Cajas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

(2020) Danping Zheng et al.   Cell Discovery

Nobiletin Ameliorates NLRP3 Inflammasome-Mediated Inflammation Through Promoting Autophagy via the AMPK Pathway

(2020) Haidong Wang et al.   MOLECULAR NEUROBIOLOGY

Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies

(2020) Gopalsamy Rajiv Gandhi et al.   Nutrients

The Role of Connexin 43 in Lung Disease

(2020) Julie A. Swartzendruber et al.   Life-Basel

NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats

(2019) Lin Chen et al.   Molecular Medicine Reports

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice

(2019) Zeng Lin et al.   Frontiers in Pharmacology

Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections

(2019) Vivek Verma et al.   Frontiers in Microbiology

Bioactive Candy: Effects of Licorice on the Cardiovascular System

(2019) Mikkel R. Deutch et al.   Foods

The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

(2018) Peter S. Kirk et al.   NEUROUROLOGY AND URODYNAMICS

Role of neurogenic inflammation in local communication in the visceral mucosa

(2018) Lori A. Birder et al.   Seminars in Immunopathology

Circadian coordination of ATP release in the urothelium via connexin43 hemichannels

(2018) Atsushi Sengiku et al.   Scientific Reports

NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation

(2018) Francis M. Hughes et al.   DIABETES

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation

(2018) Jingxiao Lu et al.   Molecular Medicine Reports

The role of gap junctions in inflammatory and neoplastic disorders (Review)

(2017) Pui Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats

(2017) Robin Lütolf et al.   NEUROUROLOGY AND URODYNAMICS

Connexins and their channels in inflammation

(2016) Joost Willebrords et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Protective Effects of Nobiletin Against Endotoxic Shock in Mice Through Inhibiting TNF-α, IL-6, and HMGB1 and Regulating NF-κB Pathway

(2016) Weifeng Li et al.   INFLAMMATION

The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction

(2016) Francis M. Hughes et al.   JOURNAL OF UROLOGY

Hydrodistention of the bladder for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC)

(2016) Tanya P. Hoke et al.   NEUROUROLOGY AND URODYNAMICS

AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis

(2016) Xiling Zhang et al.   Scientific Reports

A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels

(2015) J P Schuchardt et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome: AUA Guideline Amendment

(2015) Philip M. Hanno et al.   JOURNAL OF UROLOGY

Hydrodistension with or without fulguration of hunner lesions for interstitial cystitis: Long-term outcomes and prognostic predictors

(2015) Aya Niimi et al.   NEUROUROLOGY AND URODYNAMICS

Electrosurgical Management of Hunner Ulcers in a Referral Center's Interstitial Cystitis Population

(2015) Avinash Chennamsetty et al.   UROLOGY

Anesthetic Bladder Hydrodistention Is Superior to Superior Hypogastric Plexus Neurolysis in Treatment of Interstitial Cystitis–bladder Pain Syndrome: A Prospective Randomized Trial

(2015) Ahmed S. El-Hefnawy et al.   UROLOGY

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Randomized, double-blind, placebo-controlled, clinical study on the effect of Diabetinol® on glycemic control of subjects with impaired fasting glucose

(2015) Malkanthi Evans et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Therapeutic efficacy of narrow band imaging-assisted transurethral electrocoagulation for ulcer-type interstitial cystitis/painful bladder syndrome

(2014) Mitsuru Kajiwara et al.   INTERNATIONAL JOURNAL OF UROLOGY

Pannexin 1 Channels Play Essential Roles in Urothelial Mechanotransduction and Intercellular Signaling

(2014) Hiromitsu Negoro et al.   PLoS One

Altered Detrusor Gap Junction Communications Induce Storage Symptoms in Bladder Inflammation: A Mouse Cyclophosphamide-Induced Model of Cystitis

(2014) Takeshi Okinami et al.   PLoS One

Urinary bladder, cystitis and nerve/urothelial interactions

(2013) Lori A. Birder   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder

(2013) Céline Augé et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38

(2013) Se-Eun Jang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide

(2013) Takashi Homan et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Fulguration for Hunner Ulcers: Long-Term Clinical Outcomes

(2012) Joel H. Hillelsohn et al.   JOURNAL OF UROLOGY

Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

(2012) Hiromitsu Negoro et al.   Nature Communications

Functional characterization of a chronic cyclophosphamide-induced overactive bladder model in mice

(2011) Mathieu Boudes et al.   NEUROUROLOGY AND URODYNAMICS

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

(2010) Young-Sil Lee et al.   BIOCHEMICAL PHARMACOLOGY

An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor

(2010) Jayoung Kim et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL