Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae

(2022) Yapeng Su et al.   CELL

THE IMPACT OF COVID-19 VIRAL INFECTION ON THE HYPOTHALAMIC PITUITARY ADRENAL AXIS

(2021) Ali S. Alzahrani et al.   Endocrine Practice

Post-acute COVID-19 Syndrome. Incidence and risk factors: a Mediterranean cohort study.

(2021) Oscar Moreno-Pérez et al.   JOURNAL OF INFECTION

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

(2021) Chaolin Huang et al.   LANCET

Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities

(2021) Kaviya Selvaraj et al.   Reproductive Sciences

COVID-19 and hypogonadism: secondary immune responses rule-over endocrine mechanisms

(2021) Pallav Sengupta et al.   Human Fertility

Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron

(2021) Xinhuai Liu et al.   eLife

Attributes and predictors of long COVID

(2021) Carole H. Sudre et al.   NATURE MEDICINE

The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models

(2021) Rafal Butowt et al.   ACTA NEUROPATHOLOGICA

High-dimensional characterization of post-acute sequelae of COVID-19

(2021) Ziyad Al-Aly et al.   NATURE

Post-acute COVID-19 syndrome

(2021) Ani Nalbandian et al.   NATURE MEDICINE

A comprehensive clinical and laboratory evaluation of 224 patients with persistent symptoms attributed to presumed tick-bite exposure

(2021) Kenneth Nilsson et al.   PLoS One

Neurotropic Viruses, Astrocytes, and COVID-19

(2021) Petra Tavčar et al.   Frontiers in Cellular Neuroscience

Covid-19: Middle aged women face greater risk of debilitating long term symptoms

(2021) Ingrid Torjesen   BMJ-British Medical Journal

Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19—A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

(2021) Sherry H.-Y. Chou et al.   JAMA Network Open

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

(2021) Anton Johansson et al.   JOURNAL OF NEUROIMMUNOLOGY

Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study

(2021) Alex Buoite Stella et al.   JOURNAL OF NEUROLOGY

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study

(2021) Lixue Huang et al.   LANCET

Long COVID in a prospective cohort of home-isolated patients

(2021) Bjørn Blomberg et al.   NATURE MEDICINE

Clinical Potential of Kisspeptin in Reproductive Health

(2021) Ali Abbara et al.   TRENDS IN MOLECULAR MEDICINE

Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19

(2021) Katarzyna Bilinska et al.   Frontiers in Cellular Neuroscience

Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms

(2021) Michael J. Peluso et al.   Cell Reports

Pathological Neuroinflammatory Conversion of Reactive Astrocytes Is Induced by Microglia and Involves Chromatin Remodeling

(2021) Alejandro Villarreal et al.   Frontiers in Pharmacology

Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19

(2021) Rakhee K. Ramakrishnan et al.   Frontiers in Immunology

A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS

(2021) Angus Mackay   Frontiers in Neurology

Reactive Astrocytes: Critical Players in the Development of Chronic Pain

(2021) James Tang et al.   Frontiers in Psychiatry

Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up

(2021) Nelly Kanberg et al.   EBioMedicine

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

(2021) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Long Covid and menopause - the important role of hormones in Long Covid must be considered

(2021) Louise Newson et al.   MATURITAS

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

(2021) Jan Wenzel et al.   NATURE NEUROSCIENCE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Potential Influence of Menstrual Status and Sex Hormones on female SARS-CoV-2 Infection: A Cross-sectional Study from Multicentre in Wuhan, China

(2020) Ting Ding et al.   CLINICAL INFECTIOUS DISEASES

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evaluation of sex‐related hormones and semen characteristics in reproductive‐aged male COVID‐19 patients

(2020) Ling Ma et al.   JOURNAL OF MEDICAL VIROLOGY

Post‐discharge symptoms and rehabilitation needs in survivors of COVID‐19 infection: a cross‐sectional evaluation

(2020) Stephen J Halpin et al.   JOURNAL OF MEDICAL VIROLOGY

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

(2020) Nelly Kanberg et al.   NEUROLOGY

The Role of Astrocytes in CNS Inflammation

(2020) Federico Giovannoni et al.   TRENDS IN IMMUNOLOGY

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

(2020) Michael T. Heneka et al.   Alzheimers Research & Therapy

Effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 (COVID-19) in SARS-CoV-2 infected male patients: a cohort study

(2020) Selahittin Çayan et al.   Aging Male

Assessment and Characterization of Post‐COVID‐19 manifestations

(2020) Marwa Tolba et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

As Their Numbers Grow, COVID-19 “Long Haulers” Stump Experts

(2020) Rita Rubin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chronic COVID Syndrome: Need for an appropriate medical terminology for Long‐COVID and COVID Long‐Haulers

(2020) Abdul Mannan Baig   JOURNAL OF MEDICAL VIROLOGY

Autonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies

(2020) Melanie Dani et al.   CLINICAL MEDICINE

Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID‐19 and associated with neurological symptoms and disease severity

(2020) Johan Virhammar et al.   EUROPEAN JOURNAL OF NEUROLOGY

A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 Infection

(2020) S. Deblina Datta et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

(2020) Deidiane Elisa Ribeiro et al.   MOLECULAR PSYCHIATRY

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

(2020) Jenny Meinhardt et al.   NATURE NEUROSCIENCE

Microvascular Injury in the Brains of Patients with Covid-19

(2020) Myoung-Hwa Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Depression as a Mediator of Chronic Fatigue and Post-Traumatic Stress Symptoms in Middle East Respiratory Syndrome Survivors

(2019) So Hee Lee et al.   Psychiatry Investigation

Central sensitization predicts greater fatigue independently of musculoskeletal pain

(2019) Katie L Druce et al.   RHEUMATOLOGY

Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism

(2019) Stephanie L. Padilla et al.   CURRENT BIOLOGY

Ceasing exercise induces depression-like, anxiety-like, and impaired cognitive-like behaviours and altered hippocampal gene expression

(2019) Julie A. Morgan et al.   BRAIN RESEARCH BULLETIN

Nasal Placode Development, GnRH Neuronal Migration and Kallmann Syndrome

(2019) Hyun-Ju Cho et al.   Frontiers in Cell and Developmental Biology

Novel Neuroimmunologic Therapeutics in Depression: A Clinical Perspective on What We Know So Far

(2019) Michael Roman et al.   BRAIN BEHAVIOR AND IMMUNITY

Up‐regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine

(2019) Xue Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Correlation between Pneumonia Severity and Pulmonary Complications in Middle East Respiratory Syndrome

(2018) Wan Beom Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Disrupted hypothalamic functional connectivity in patients with PD and autonomic dysfunction

(2018) Eran Dayan et al.   NEUROLOGY

Metabolic signaling in the brain and the role of astrocytes in control of glutamate and GABA neurotransmission

(2018) Arne Schousboe   NEUROSCIENCE LETTERS

Neurokinin 3 receptor antagonism – a novel treatment for menopausal hot flushes

(2018) Manish Modi et al.   NEUROENDOCRINOLOGY

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome

(2018) Mami Noda et al.   Frontiers in Psychiatry

Glial EAAT2 regulation of extracellular nTS glutamate critically controls neuronal activity and cardiorespiratory reflexes

(2017) Michael P. Matott et al.   JOURNAL OF PHYSIOLOGY-LONDON

Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders

(2016) Alexei Verkhratsky et al.   NEUROBIOLOGY OF DISEASE

Astrocytes: Orchestrating synaptic plasticity?

(2016) M. De Pittà et al.   NEUROSCIENCE

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

(2016) Raman Saggu et al.   Acta Neuropathologica Communications

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Neurokinin B Administration Induces Hot Flushes in Women

(2015) Channa N. Jayasena et al.   Scientific Reports

The kisspeptin-GnRH pathway in human reproductive health and disease

(2014) Karolina Skorupskaite et al.   HUMAN REPRODUCTION UPDATE

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

Glutathione-Dependent Detoxification Processes in Astrocytes

(2014) Ralf Dringen et al.   NEUROCHEMICAL RESEARCH

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes

(2013) Naomi E. Rance et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight

(2012) Melinda A. Mittelman-Smith et al.   ENDOCRINOLOGY

Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature

(2012) M. A. Mittelman-Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study

(2011) Harvey Moldofsky et al.   BMC Neurology

In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome

(2011) Jo Nijs et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis

(2011) Leighton R. Barnden et al.   NMR IN BIOMEDICINE

Anatomy of the kisspeptin neural network in mammals

(2010) Michael N. Lehman et al.   BRAIN RESEARCH

Role of Excitatory Amino Acid Transporter-2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics

(2010) Keetae Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Timing and completion of puberty in female mice depend on estrogen receptor  -signaling in kisspeptin neurons

(2010) C. Mayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status

(2010) Jenny C. NGAI et al.   RESPIROLOGY

Mental Morbidities and Chronic Fatigue in Severe Acute Respiratory Syndrome Survivors

(2009) Marco Ho-Bun Lam   ARCHIVES OF INTERNAL MEDICINE

The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction

(2008) Alastair V Ferguson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS