SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties
Authors
Keywords
SARS-CoV-2, Spike protein, S1 subunit, PAMP, TLR, Neuroinflammation, Microglia, Sickness behavior
Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 100, Issue -, Pages 267-277
Publisher
Elsevier BV
Online
2021-12-14
DOI
10.1016/j.bbi.2021.12.007
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cerebrospinal fluid in COVID-19: A systematic review of the literature
- (2021) Ariane Lewis et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains
- (2021) Rongrong Chen et al. Frontiers in Neurology
- COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital
- (2021) Kiran T Thakur et al. BRAIN
- SARS-CoV-2 spike protein interacts with and activates TLR41
- (2021) Yingchi Zhao et al. CELL RESEARCH
- Serum levels of SARS-CoV-2 nucleocapsid antigen associate with inflammatory status and disease severity in COVID-19 patients
- (2021) Francesco Perna et al. CLINICAL IMMUNOLOGY
- Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by Dexamethasone
- (2021) Olumayokun A. Olajide et al. INFLAMMATION
- TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
- (2021) Min Zheng et al. NATURE IMMUNOLOGY
- Post-acute COVID-19 syndrome
- (2021) Ani Nalbandian et al. NATURE MEDICINE
- How COVID-19 Affects the Brain
- (2021) Maura Boldrini et al. JAMA Psychiatry
- Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19
- (2021) Mahdi Eskandarian Boroujeni et al. ACS Chemical Neuroscience
- Mechanical activation of spike fosters SARS-CoV-2 viral infection
- (2021) Wei Hu et al. CELL RESEARCH
- Dysregulation of brain and choroid plexus cell types in severe COVID-19
- (2021) Andrew C. Yang et al. NATURE
- High Performance of SARS-Cov-2N Protein Antigen Chemiluminescence Immunoassay as Frontline Testing for Acute Phase COVID-19 Diagnosis: A Retrospective Cohort Study
- (2021) Qiaoling Deng et al. Frontiers in Medicine
- Psychiatric and neuropsychiatric sequelae of COVID-19 – A systematic review
- (2021) Thor Mertz Schou et al. BRAIN BEHAVIOR AND IMMUNITY
- ACE2 expression in rat brain: Implications for COVID-19 associated neurological manifestations
- (2021) Vito S. Hernández et al. EXPERIMENTAL NEUROLOGY
- SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia
- (2021) Olumayokun A. Olajide et al. MOLECULAR NEUROBIOLOGY
- The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
- (2021) Jan Wenzel et al. NATURE NEUROSCIENCE
- Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
- (2021) Maxime Taquet et al. PLOS MEDICINE
- Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection
- (2021) Destin Groff et al. JAMA Network Open
- A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- Steroid‐responsive encephalitis in Covid‐19 disease
- (2020) Andrea Pilotto et al. ANNALS OF NEUROLOGY
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Severe Covid-19
- (2020) David A. Berlin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mild or Moderate Covid-19
- (2020) Rajesh T. Gandhi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
- (2020) Shelli Farhadian et al. BMC Neurology
- COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation
- (2020) Duraisamy Kempuraj et al. NEUROSCIENTIST
- Distinct conformational states of SARS-CoV-2 spike protein
- (2020) Yongfei Cai et al. SCIENCE
- Increased CSF levels of IL-1β, IL-6, and ACE in SARS-CoV-2–associated encephalitis
- (2020) Marta Bodro et al. Neurology-Neuroimmunology & Neuroinflammation
- Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease
- (2020) Alana F Ogata et al. CLINICAL CHEMISTRY
- The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
- (2020) Elizabeth M. Rhea et al. NATURE NEUROSCIENCE
- SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
- (2020) Lizhou Zhang et al. Nature Communications
- Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be
- (2020) Giuseppina Mariano et al. Frontiers in Molecular Biosciences
- Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein
- (2020) Gerard J. Nuovo et al. Annals of Diagnostic Pathology
- Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ
- (2019) Thuy-Truc Ta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toll-like receptors in the pathogenesis of neuroinflammation
- (2019) V. Kumar JOURNAL OF NEUROIMMUNOLOGY
- Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming
- (2018) Matthew G. Frank et al. BRAIN BEHAVIOR AND IMMUNITY
- Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells
- (2018) Felix M. Behr et al. Frontiers in Immunology
- Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production
- (2016) Nicholas G. Spencer et al. PLoS One
- Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
- (2016) Aleksandra Deczkowska et al. TRENDS IN IMMUNOLOGY
- BORIS: a free, versatile open-source event-logging software for video/audio coding and live observations
- (2016) Olivier Friard et al. Methods in Ecology and Evolution
- Microglial priming in neurodegenerative disease
- (2014) V. Hugh Perry et al. Nature Reviews Neurology
- Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells
- (2013) Stephanie Denieffe et al. BRAIN BEHAVIOR AND IMMUNITY
- Chemokine CXCL1 Dimer Is a Potent Agonist for the CXCR2 Receptor
- (2013) Aishwarya Ravindran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis
- (2013) Huan Yang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Immune-neural connections: how the immune system's response to infectious agents influences behavior
- (2012) R. H. McCusker et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses
- (2012) Matthew G. Frank et al. JOURNAL OF NEUROIMMUNOLOGY
- Pathogen Recognition by the Innate Immune System
- (2011) Himanshu Kumar et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Long Term Potentiation Is Impaired in Membrane Glycoprotein CD200-deficient Mice
- (2011) Derek A. Costello et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nlrp3: An immune sensor of cellular stress and infection
- (2010) Mohamed Lamkanfi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
- (2010) Taro Kawai et al. NATURE IMMUNOLOGY
- Microglial Physiology: Unique Stimuli, Specialized Responses
- (2009) Richard M. Ransohoff et al. Annual Review of Immunology
- Cytokine, Sickness Behavior, and Depression
- (2009) Robert Dantzer IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
- Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions
- (2009) Nathalie Koning et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Interleukin-1 (IL-1): A central regulator of stress responses
- (2008) Inbal Goshen et al. FRONTIERS IN NEUROENDOCRINOLOGY
- Peptides of CD200 Modulate LPS-Induced TNF-α Induction and Mortality In Vivo
- (2007) Reg Gorczynski et al. JOURNAL OF SURGICAL RESEARCH
- From inflammation to sickness and depression: when the immune system subjugates the brain
- (2007) Robert Dantzer et al. NATURE REVIEWS NEUROSCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started