Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Loss of NDG-4 extends lifespan and stress resistance inCaenorhabditis elegans

(2013) Jeanette Brejning et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Yeast replicative aging: a paradigm for defining conserved longevity interventions

(2013) Brian M. Wasko et al.   FEMS YEAST RESEARCH

Five Conditions Commonly Used to Down-regulate Tor Complex 1 Generate Different Physiological Situations Exhibiting Distinct Requirements and Outcomes

(2013) Jennifer J. Tate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Drugs that modulate aging: the promising yet difficult path ahead

(2013) Brian K. Kennedy et al.   Translational Research

Tryptophan metabolism: entering the field of aging and age-related pathologies

(2013) Annemieke T. van der Goot et al.   TRENDS IN MOLECULAR MEDICINE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Genetic Determinants of Cell Size at Birth and Their Impact on Cell Cycle Progression in Saccharomyces cerevisiae

(2013) Sandra K. Truong et al.   G3-Genes Genomes Genetics

Pharmacological lifespan extension of invertebrates

(2012) Mark Lucanic et al.   AGEING RESEARCH REVIEWS

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing

(2012) Carl J. Mousley et al.   CELL

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Cell Size Control in Yeast

(2012) Jonathan J. Turner et al.   CURRENT BIOLOGY

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Genome-Scale Studies of Aging: Challenges and Opportunities

(2012) Mark A. McCormick et al.   CURRENT GENOMICS

Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al

(2012) Austen R.D. Ganley et al.   FEMS YEAST RESEARCH

Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al.

(2012) Matt Kaeberlein   FEMS YEAST RESEARCH

Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae

(2012) P. O. Ljungdahl et al.   GENETICS

Morphogenesis and the Cell Cycle

(2012) Audrey S. Howell et al.   GENETICS

Ibuprofen blood plasma levels and onset of analgesia

(2012) D. R. Mehlisch et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

An expanding range of targets for kynurenine metabolites of tryptophan

(2012) Trevor W. Stone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Systematic Analysis of Cell Cycle Regulators in Yeast Reveals That Most Factors Act Independently of Cell Size to Control Initiation of Division

(2012) Scott A. Hoose et al.   PLoS Genetics

Sir2 deletion prevents lifespan extension in 32 long-lived mutants

(2011) Joe R. Delaney et al.   AGING CELL

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

(2011) Tsui-Ting Ching et al.   AGING CELL

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast

(2011) Joe R. Delaney et al.   CELL CYCLE

Cell size and growth rate are major determinants of replicative lifespan

(2011) Jingye Yang et al.   CELL CYCLE

Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast

(2011) Tomasz Biliński et al.   FEMS YEAST RESEARCH

Extension of life span of Drosophila melanogaster by the inhibitors of tryptophan-kynurenine metabolism

(2011) Gregory F. Oxenkrug et al.   FLY

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Could over-the-counter treatment protect against Parkinson disease?

(2011) Carolyn McSharry   Nature Reviews Neurology

Use of ibuprofen and risk of Parkinson disease

(2011) X. Gao et al.   NEUROLOGY

TOR and ageing: a complex pathway for a complex process

(2010) M. A. McCormick et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Kingdoms Protozoa and Chromista and the eozoan root of the eukaryotic tree

(2009) T. Cavalier-Smith   Biology Letters

Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ1–42 transgenic C. elegans

(2009) Masahiko Morita et al.   BRAIN RESEARCH

Direct evidence of the cyclooxygenase pathway of prostaglandin synthesis in arthropods: Genetic and biochemical characterization of two crustacean cyclooxygenases

(2009) Külliki Varvas et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Measuring Caenorhabditis elegans Life Span on Solid Media

(2009) George L. Sutphin et al.   Jove-Journal of Visualized Experiments

Measuring Replicative Life Span in the Budding Yeast

(2009) Kristan K. Steffen et al.   Jove-Journal of Visualized Experiments

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Replicative Aging in Yeast: The Means to the End

(2008) K.A. Steinkraus et al.   Annual Review of Cell and Developmental Biology

Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

(2008) David Gems et al.   Cell Metabolism

Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation

(2008) T. L. Tootle et al.   DEVELOPMENT

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

(2008) E. D. Smith et al.   GENOME RESEARCH

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY