Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Silica nanoparticles induce JNK-mediated inflammation and myocardial contractile dysfunction

(2020) Lin Feng et al.   JOURNAL OF HAZARDOUS MATERIALS

Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

(2019) Lin Feng et al.   Particle and Fibre Toxicology

Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function

(2019) Omar Lozano et al.   Oxidative Medicine and Cellular Longevity

Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats

(2019) Stefano Rossi et al.   Particle and Fibre Toxicology

Functional, inflammatory and interstitial impairment due to artificial stone dust ultrafine particles exposure

(2019) Noa Ophir et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Mitochondrial dysfunction, perturbations of mitochondrial dynamics and biogenesis involved in endothelial injury induced by silica nanoparticles

(2018) Caixia Guo et al.   ENVIRONMENTAL POLLUTION

ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia

(2018) Qadeer Aziz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanomedicine for the cardiac myocyte: Where are we?

(2018) Omar Lozano et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of cardiovascular responses to silver nanoparticles (AgNPs) in spontaneously hypertensive rats

(2018) Manuel Alejandro Ramirez-Lee et al.   Nanomedicine-Nanotechnology Biology and Medicine

Ex Vivo Cardiotoxicity of Antineoplastic Casiopeinas Is Mediated through Energetic Dysfunction and Triggered Mitochondrial-Dependent Apoptosis

(2018) Christian Silva-Platas et al.   Oxidative Medicine and Cellular Longevity

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes

(2018) Chrishan J.A. Ramachandra et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inhibition of gap junction intercellular communication is involved in silica nanoparticles-induced H9c2 cardiomyocytes apoptosis via the mitochondrial pathway

(2017) Zhongjun Du et al.   International Journal of Nanomedicine

Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload

(2017) Yuriana Oropeza-Almazán et al.   Oxidative Medicine and Cellular Longevity

Mdivi-1 Protects Human W8B2+ Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury

(2017) Ayeshah A. Rosdah et al.   STEM CELLS AND DEVELOPMENT

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics

(2016) Guillermo U. Ruiz-Esparza et al.   EUROPEAN JOURNAL OF HEART FAILURE

Antineoplastic copper coordinated complexes (Casiopeinas) uncouple oxidative phosphorylation and induce mitochondrial permeability transition in cardiac mitochondria and cardiomyocytes

(2016) Christian Silva-Platas et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models

(2016) Zhong Jian et al.   PLoS One

Protein corona acts as a protective shield against Fe 3 O 4 -PEG inflammation and ROS-induced toxicity in human macrophages

(2016) V. Escamilla-Rivera et al.   TOXICOLOGY LETTERS

Autophagy and autophagy dysfunction contribute to apoptosis in HepG2 cells exposed to nanosilica

(2016) Yongbo Yu et al.   Toxicology Research

Silica nanoparticle-generated ROS as a predictor of cellular toxicity: mechanistic insights and safety by design

(2016) Sean E. Lehman et al.   Environmental Science-Nano

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

(2016) Gentaro Ikeda et al.   Scientific Reports

Physicochemical and toxicological evaluation of silica nanoparticles suitable for food and consumer products collected by following the EC recommendation

(2015) Catia Contado et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enhanced oxidative stress sensitizes the mitochondrial permeability transition pore to opening in heart from Zucker Fa/fa rats with type 2 diabetes

(2015) Adriana Riojas-Hernández et al.   LIFE SCIENCES

Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos

(2015) Junchao Duan et al.   Nanotoxicology

Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity

(2014) E Fernández-Sada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation

(2014) Abderrahim Nemmar et al.   International Journal of Nanomedicine

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

(2014) Junchao Duan et al.   Particle and Fibre Toxicology

Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue

(2014) Monia Savi et al.   Particle and Fibre Toxicology

Cardiovascular Toxicity of Different Sizes Amorphous Silica Nanoparticles in Rats After Intratracheal Instillation

(2013) Zhongjun Du et al.   Cardiovascular Toxicology

Echocardiographic Assessment of Cardiac Structural and Functional Indices in Broiler Chickens Treated with Silver Nanoparticles

(2013) Hamid Raieszadeh et al.   TheScientificWorldJOURNAL

Mechanism of cellular uptake of genotoxic silica nanoparticles

(2012) Qingshan Mu et al.   Particle and Fibre Toxicology

Methods in cardiomyocyte isolation, culture, and gene transfer

(2011) William E. Louch et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assessment of cellular toxicity of TiO2nanoparticles for cardiac tissue engineering applications

(2010) Hedeer Jawad et al.   Nanotoxicology

Presence and risks of nanosilica in food products

(2010) Susan Dekkers et al.   Nanotoxicology

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells

(2010) Mohd Javed Akhtar et al.   TOXICOLOGY

Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line

(2010) Yiyi Ye et al.   TOXICOLOGY IN VITRO

What does the cell see?

(2009) Iseult Lynch et al.   Nature Nanotechnology

Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO2Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population

(2008) Zhen Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Role of sarcolemmal ATP-sensitive K+channels in the regulation of sinoatrial node automaticity: an evaluation using Kir6.2-deficient mice

(2008) Koichi Fukuzaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Mechanisms and Potential Clinical Significance of S-Glutathionylation

(2007) Isabella Dalle–Donne et al.   ANTIOXIDANTS & REDOX SIGNALING